姓        名：岳锐

行政职务：副院长

学       位：博士

导师情况：博士生导师

研究领域：成体干细胞与再生医学

研究方向：

E-mail:ryue@tongji.edu.cn

办公室电话：021-65983623

实验室电话：021-65983287

通讯地址：上海市四平路1239号道交馆432室

1.科技部，国家重点研发计划（干细胞研究与器官修复），2022YFA1103200，骨骼与血液干细胞休眠和激活调控，2022-12至2027-12，2800万元，在研，主持

2.科技部，国家重点研发计划（干细胞及转化研究）青年项目，2017YFA0106400，骨髓间充质干细胞调控机制及其与造血干细胞的相互作用研究，2017-07至2021-12，577万元，已结题，主持

3.科技部，国家重点研发计划（干细胞研究与器官修复），2021YFA1100900，骨髓内造血干细胞发育和再生的调控机制及干预策略，2021-12至2026-06，182万，在研，课题骨干

4.国家自然科学基金委，重大研究计划（器官衰老与器官退行性变化的机制）培育项目，91749124，骨髓微环境的衰老机制研究，2018-01至2020-12，80万元，已结题，主持

5.国家自然科学基金委，面上项目，81772389，Clec11a/Osteolectin促进成骨分化的机制与临床应用研究，2018-01至2021-12，66万元，已结题，主持

6.国家自然科学基金委，面上项目，82070108，IGF-1在骨髓微环境中的调控作用研究，2021-01至 2024-12，56万元，在研，主持

7.同济大学，学科交叉重点项目，kx0200020173386，颅面骨来源的骨髓间充质干细胞谱系层级对成骨功能的影响，2017-07至2020-12,60万元，已结题，主持

代表论文(#Co-first author, *Co-corresponding author)：

1. Zhang, X.#, Cao, D.#, Xu, L.#, Xu, Y.#, Gao, Z., Pan, Y., Jiang, M., Wei, Y., Wang, L., Liao, Y., Wang, Q., Yang, L., Xu, X., Gao, Y., Gao, S., Wang, J., and Yue, R. (2023) Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation. Cell Stem Cell 30, 378-395 e378 (Feature Article, Previewed by Cell Stem Cell)

2. Sun, Y.#, Ma, M.#, Cao, D., Zheng, A., Zhang, Y., Su, Y., Wang, J., Xu, Y., Zhou, M., Tang, Y., Liu, Y., Ma, T., Fan, A., Zhang, X., Zhu, Q., Qin, J., Mo, C., Xu, Y., Zhang, L.*, Xu, D.*, and Yue, R.* (2023) Inhibition of Fap Promotes Cardiac Repair by Stabilizing BNP. Circ Res 132, 586-600 (Feature Article)

3. Wang, J., Zhu, Q., Cao, D., Peng, Q., Zhang, X., Li, C., Zhang, C., Zhou, B. O., and Yue, R. (2023) Bone marrow-derived IGF-1 orchestrates maintenance and regeneration of the adult skeleton. Proc Natl Acad Sci U S A 120, e2203779120

4. Fan, A.#, Wu, G.#, Wang, J., Lu, L., Wang, J., Wei, H., Sun, Y., Xu, Y., Mo, C., Zhang, X., Pang, Z., Pan, Z., Wang, Y., Lu, L., Fu, G., Ma, M., Zhu, Q., Cao, D., Qin, J., Yin, F.*, and Yue, R.* (2023) Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression. Bone Res 11, 3

5. Zhu, Q., Ding, L., and Yue, R. (2022) Skeletal stem cells: a game changer of skeletal biology and regenerative medicine? Life Med 1, 294-306 (Cover Story)

6.Mo, C.#, Guo, J.#, Qin, J., Zhang, X., Sun, Y., Wei, H., Cao, D., Zhang, Y., Zhao, C., Xiong, Y., Zhang, Y., Sun, Y., Shen, L.*, and Yue, R.* (2022) Single-cell transcriptomics of LepR-positive skeletal cells reveals heterogeneous stress-dependent stem and progenitor pools. EMBO J 41, e108415 (Cover Story, Previewed by EMBO Journal)

7.He, J.#, Yan, J.#, Wang, J.#, Zhao, L.#, Xin, Q.#, Zeng, Y., Sun, Y., Zhang, H., Bai, Z., Li, Z., Ni, Y., Gong, Y., Li, Y., 8.He, H., Bian, Z., Lan, Y., Ma, C., Bian, L., Zhu, H.*, Liu, B.*, and Yue, R.* (2021) Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses. Cell Res 31, 742-757 (Cover Story)

9.Wei, H.#, Xu, Y.#, Wang, Y.#, Xu, L., Mo, C., Li, L., Shen, B., Sun, Y., Cheng, P., Yang, L., Pang, Y., Qin, A., Cao, Y., Morrison, S. J., and Yue, R. (2020) Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target. Cell Rep 33, e108252 (Highlighted by Nature Reviews Endocrinology, Recommended by F1000)

10.Yue, R. (2019) Advice for the Next Generation: Rui Yue. Cell Stem Cell 24, 9-11

11.Shen, B., Vardy, K., Hughes, P., Tasdogan, A., Zhao, Z., Yue, R., Crane, G. M., and Morrison, S. J. (2019) Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass. eLife 8, e42274

12.Han, X., Wang, R., Zhou, Y., Fei, L., Sun, H., Lai, S., Saadatpour, A., Zhou, Z., Chen, H., Ye, F., Huang, D., Xu, Y., Huang, W., Jiang, M., Jiang, X., Mao, J., Chen, Y., Lu, C., Xie, J., Fang, Q., Wang, Y., Yue, R., Li, T., Huang, H., Orkin, S. H., Yuan, G. C., Chen, M., and Guo, G. (2018) Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107

13.Zhou, B. O., Yu, H., Yue, R., Zhao, Z., Rios, J. J., Naveiras, O., and Morrison, S. J. (2017) Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF. Nat Cell Biol 19, 891-903

14.Yue, R., Shen, B., and Morrison, S. J. (2016) Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton. eLife 5, e18782 (Previewed by eLife)

15.Yue, R., Zhou, B. O., Shimada, I. S., Zhao, Z., and Morrison, S. J. (2016) Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow. Cell Stem Cell 18, 782-796(Previewed by Cell Stem Cell)

16.Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., and Morrison, S. J. (2014) Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell 15, 154-168

17.Li, H.#, Yue, R.#, Wei, B., Gao, G., Du, J., and Pei, G. (2014) Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis. EMBO J 33, 1383-1396

18.Yue, R.#, Li, H.#, Liu, H., Li, Y., Wei, B., Gao, G., Jin, Y., Liu, T., Wei, L., Du, J., and Pei, G. (2012) Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition. Dev Cell 22, 1092-1100

19.Yue, R., Kang, J., Zhao, C., Hu, W., Tang, Y., Liu, X., and Pei, G. (2009) Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell 139, 535-546

本课题组常年招聘博士后，待遇从优。欢迎博士生、硕士生和本科生报考与实习。