姓        名：刘文强

学        位：博士

导师情况：博士生导师

研究领域：发育与生殖生物学

研究方向：

1．哺乳动物及人早期胚胎发育调控。 
2．胚胎发育异常的机制及干预。 
3．不育不孕的遗传学机制及辅助生殖技术。
E-mail：liuwenqiang@tongji.edu.cn
联系电话：021-65982276
通讯地址：上海市四平路1239号同济大学生命科学与技术学院
实验室网址：gaolab.tongji.edu.cn
 

个人简介:

刘文强，同济大学生命科学与技术学院/同济大学附属妇产科医院，教授，博士生导师。上海市母胎医学与妇科肿瘤研究所副所长，科技部重点研发计划（青年）首席科学家。入选国家自然科学基金优青项目、上海市青年拔尖人才计划、上海市科技启明星计划。获教育部自然科学奖一等奖、同济大学“青年五四奖章”。

2007年毕业于西北农林科技大学，获学士学位；2010年毕业于西北农林科技大学，获硕士学位；2014年毕业于中国农业大学/北京生命科学研究所，获博士学位；2014年8月至今任职于同济大学/同济大学附属妇产科医院。主要从事早期胚胎发育和人辅助生殖研究。近年来在Nature，Cell Stem Cell，Nature Cell Biology，Cell Reports，Cell Discovery等知名学术期刊发表论文 30 余篇。

发表论文：

1．Chenxiang Xi#; Zihui Yan#; Dandan Bai#; Yalin Zhang#; Beiying Wang#; Xiaoxiao Han#; Li Wu; Xiaohui Shi; Zhiyi Hu; Ming Tang; Zhongqu Su; Yingdong Liu; Binya Liu; Jiqing Yin; Hong Wang; Xiaocui Li*; Yanping Zhang*; Shaorong Gao*; Wenqiang Liu*; Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy, Protein & Cell, 2024, DOI: doi.org/10.1093/procel/pwae006.

2．Yanhe Li#; Caihong Zheng#; Yingdong Liu; Jincan He; Qiang Zhang; Yalin Zhang; Xiaochen Kou; Yanhong Zhao; Kuisheng Liu; Dandan Bai; Yanping Jia; Xiaoxiao Han; Yifan Sheng; Jiqing Yin; Hong Wang; Shuai Gao*; Wenqiang Liu*; Shaorong Gao*; Inhibition of Wnt activity improves periimplantation development of somatic cell nuclear transfer embryos, National Science Review, 2023, 10(9): nwad173.

3．Kuisheng Liu#; Xiaocui Xu#; Dandan Bai#; Yanhe Li; Yalin Zhang; Yanping Jia; Mingyue Guo; Xiaoxiao Han; Yingdong Liu; Yifan Sheng; Xiaochen Kou; Yanhong Zhao; Jiqing Yin; Sheng Liu; Jiayu Chen; Hong Wang; Yixuan Wang; Wenqiang Liu*; Shaorong Gao*; Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm, Protein & Cell, 2023, 14(4): 262-278.

4．Hui Yang#; Dandan Bai#; Yanhe Li#; Zhaowei Yu#; Chenfei Wang; Yifan Sheng; Wenqiang Liu*; Shaorong Gao*; Yong Zhang*; Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo, Nature Cell Biology, 2022, 24(5): 783-792.

5．Dandan Ba#i; Jin Sun#; Chuan Chen; Yanping Jia; Yanhe Li; Kuisheng Liu; Yalin Zhang; Jiqing Yin; Yingdong Liu; Xiaoxiao Han; Jingling Ruan; Xiaochen Kou; Yanhong Zhao; Hong Wang; Zheng Wang; Miaoxin Chen; Xiaoming Teng; Cizhong Jiang*; Shaorong Gao*; Wenqiang Liu*; Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos, Cell Reports, 2022, 39(5): 110784.

6．Guang Yang#; Linfeng Zhang#; Wenqiang Liu#; Zhibin Qiao; Shijun Shen; Qianshu Zhu; Rui Gao; Mengting Wang; Mingzhu Wang; Chong Li; Meng Liu; Jin Sun; Liping Wang; Wenju Liu; Xinyu Cui; Kun Zhao; Ruge Zang; Mo Chen; Zehang Liang; Lu Wang; Xiaochen Kou; Yanhong Zhao; Hong Wang; Yixuan Wang; Shaorong Gao*; Jiayu Chen*; Cizhong Jiang*; Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer, Cell Stem Cell, 2021, 28(1): 150-163.

7．Yanhe Li; Yuteng Weng; Dandan Bai; Yanping Jia; Yingdong Liu; Yalin Zhang; Xiaochen Kou; Yanhong Zhao; Jingling Ruan; Jiayu Chen; Jiqing Yin; Hong Wang; Xiaoming Teng; Zuolin Wang; Wenqiang Liu*; Shaorong Gao*; Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation, Nature Communications, 2020, 11(1): 45933.

8．Chengchen Zhao#; Naiqian Zhang#; Yalin Zhang#; Nuermaimaiti Tuersunjiang; Shaorong Gao; Wenqiang Liu*; Yong Zhang*; A DNA methylation state transition model reveals the programmed epigenetic heterogeneity in human pre-implantation embryos, Genome Biology, 2020, 21(1): 277.

9．Dandan Bai#; Jin Sun#; Yanping Jia#; Jiqing Yin; Yalin Zhang; Yanhe Li; Rui Gao; Xiling Du; Kunming Li; Jiaming Lin; Zhifen Tu; Yu Wang; Jiaping Pan; Shanshan Liang; Yi Guo; Jingling Ruan; Xiaochen Kou; Yanhong Zhao; Hong Wang; Cizhong Jiang; Fengchao Wang; Xiaoming Teng*; Wenqiang Liu*; Shaorong Gao*; Genome transfer for the prevention of female infertility caused by maternal gene mutation, Journal of Genetics and Genomics, 2020, 47(6): 311-319.

10．Yingdong Liu#; Yanping Zhang#; Jiqing Yin; Yawei Gao; Yanhe Li; Dandan Bai; Wenteng He; Xueliang Li; Pengfei Zhang; Rongnan Li; Lingkai Zhang; Yanping Jia; Yalin Zhang; Jiaming Lin; Yi Zheng; Hong Wang; Shaorong Gao*; Wenxian Zeng*; Wenqiang Liu*; Distinct H3K9me3 and DNA methylation modifications during mouse spermatogenesis., Journal of Biological Chemistry, 2019, 294(49): 18714-18725.

11．Rui Gao#, Chenfei Wang#, Yawei Gao#, Wenchao Xiu, Jiayu Chen, Xiaochen Kou, Yanhong Zhao, Yuhan Liao, Dandan Bai, Zhibin Qiao, Lei Yang, Mingzhu Wang, Ruge Zang, Xiaoyu Liu, Yanping Jia, Yanhe Li, Yalin Zhang, Jiqing Yin, Hong Wang, Xiaoping Wan, Wenqiang Liu*, Yong Zhang*, Shaorong Gao*. Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos.Cell Stem Cell, 2018,23 (3), 426-435

12．Wenqiang Liu#, Kunming Li#, Dandan Bai#, Jiqing Yin#, Yuanyuan Tang, Fengli Chi, Linfeng Zhang, Yu Wang, Jiaping Pan, Shanshan Liang, Yi Guo, Jingling Ruan, Xiaochen Kou, Yanhong Zhao, Hong Wang, Jiayu Chen*, Xiaoming Teng*, Shaorong Gao*. Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility.Human Genetics, 2017, 136 (8), 975-985

13．Yi Guo#, Wen qiang Liu#, Yu Wang, Jiaping Pan, Shanshan Liang, Jingling Ruan, Xiaoming Teng*. Polarization microscopy imaging for the identification of unfertilized oocytes following short-term insemination. Fertility and Sterility, 2017, 108 (1), 78-83

14．Xiaoyu Liu#, Chenfei Wang#, Wenqiang Liu#, Jingyi Li#, Chong Li, Xiaochen Kou, Jiayu Chen, Yanhong Zhao, Haibo Gao, Hong Wang, Yong Zhang*, Yawei Gao*&Shaorong Gao*. Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos. Nature, 2016, 537, 558–562

15．Wenqiang Liu#, Xiaoyu Liu#, Chenfei Wang#, Yawei Gao#*, Rui Gao, Xiaochen Kou, Yanhong Zhao, Jingyi Li, You Wu, Wenchao Xiu, Su Wang, Jiqing Yin, Wei Liu, Tao Cai, Hong Wang, Yong Zhang*, Shaorong Gao*. Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing.Cell Discovery, 2016, 2：16010

16．Wenqiang Liu, Jiqing Yin, Xiaochen Kou, Yonghua Jiang, Haibo Gao, Yanhong Zhao, Bo Huang, Wenteng He, Hong Wang, Zhiming Han*, and Shaorong Gao* Asymmetric reprogramming capacity of parental pronuclei in mouse zygotes.Cell reports, 2014, 6 (6): 1008-1016 7.9