姓 名：常建锋

学 位：博士

研究方向：表观遗传学、干细胞衰老与肿瘤

E-mail address：jfchang@tongji.edu.cn

通讯地址： 上海市杨浦区四平路1239号 同济大学生命科学与技术学院

个人简介:

2002年毕业于兰州大学生命科学学院，获学士生物技术专业学位，2007年获兰州大学植物学博士学位，2007年至2011年在清华大学医学院从事表观遗传学方向博士后研究，2011年至今在同济大学生命科学与技术学院工作。

发表论文:

 Peer reviewed articles ( * equal contribution)

1.         Yuan-Ya Jing, Feng-Feng Cai, Lei Zhang, Jing Han, Lu Yang, Fan Tang, Ya-Bin Li, Jian-Feng Chang, Feng Sun, Xiao-Mei Yang, Fang-Lin Sun, Su Chen. Epigenetic regulation of the Warburg effect by H2B monoubiquitination. Cell Death & Differentiation (2019). 27(5): 1660-1676.

2.        Kai-Le Li, Lei Zhang, Xiao-Mei Yang, Qiang Fang, Xue-Fang Yin, Hui-Min Wei, Ting Zhou, Ya-Bin Li, Xue-Lin Chen, Fan Tang, Yong-Hao Li, Jian-Feng Chang*, Wei Li*, Feng Sun*. Histone acetyltransferase CBP-related H3K23 acetylation contributes to courtship learning in Drosophila. BMC Developmental Biology. (2018) 18:20. (*co-corresponding author)

3.        Xuan Kang, Yun Feng, Zhixue Gan, Shiyang Zeng, Xiaobo Guo, Xirui Chen, Ye Zhang,Chen Wang, Kuinan Liu, Xuelin Chen, Xiaoxue Jianga Shuting Song, Yabin Li, Su Chen,Feng Sun, Zhiyong Mao, Xiaomei Yang, Jianfeng Chang. NASP antagonize chromatin accessibility through maintaining histone H3K9me1 in hepatocellular carcinoma. BBA - Molecular Basis of Disease 1864 (2018) 3438–3448. (corresponding author)

4.        Ye Zhang*, Jian-Feng Chang*, Jin Sun*, Lu Chen, Xiao-Mei Yang, Huan-Yin Tang, Yuan-Ya Jing, Xuan Kang, Zhi-Min He, Jun-Yu Wu, Hui-Min Wei, Da-Liang Wang,Rong-Gang Xu, Rui-Bao Zhu, Ying Shen, Shi-Yang Zeng, Chen Wang, Kui-Nan Liu,Yong Zhang, Zhi-Yong Mao, Ci-Zhong Jiang and Fang-Lin Sun. Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability. J Cell Sci 2018 131: jcs215525 doi: 10.1242/jcs.215525. (*co-first author)

5.        Zekun Liu, Qing-bin Zhang, Chen Bu, Dawei Wang, Kai Yu, Zhixue Gan, Jianfeng Chang,  Zhongyi Cheng and Zexian Liu. Quantitative Dynamics of Proteome, Acetylome, and Succinylome during Stem-Cell Differentiation into Hepatocyte-like Cells. J. Proteome Res.2018, 17, 2491−2498.

6.         Su Chen, Yuanya Jing Xuan Kang, Lu Yang, Da-Liang Wang, Wei Zhang, Lei Zhang, Ping Chen, Jian-Feng Chang, Xiao-Mei Yang, Fang-Lin Sun. Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy. Nucleic acid research, (2017) 45 (3),1144-1158.

7.         You Wu, Ping Chen, Yu-Long Men, Yuanya Jing, Chen Wang, Qiang Wang, Zhixue Gan, Jin Huang, Kun Xie, Pei-Chao Chen, Fengfeng Cai, Jian-Feng Chang, Su Chen. Microarray analysis reveals the potential biological functions of H2B monoubiquitination. (2015) PLoS ONE 10(7): e0133444.

8.        Chen Wang, Jian-Feng Chang, Da-Liang Wang, Yan Liu, Meng Zhang, Yu-Long Men, Dongdong Lu, Xiao-Mei Yang, Su Chen, Fang-Lin Sun. A Conserved RAD6-MDM2 Ubiquitin Ligase Machinery Targets Histone Chaperone ASF1A in Tumorigenesis. Oncotarget. 2015 Oct 6; 6(30): 29599–29613.

9.        Jin Sun, Huimin wei, Jiang Xu, Jian-Feng Chang, Zhihao Yang, Xingjie Ren, Wen-Wen Lv, Lu-Ping Liu, Li-Xia Pan, Xia Wang, Huan-Huan Qiao, Bing Zhu, Jun-Yuan Ji, Dong Yan, Ting Xie, Fang-Lin Sun, and Jian-Quan Ni. Histone H1-Mediated Epigenetic Regulation Controls Germline Stem Cell Self-Renewal by Modulating the Acetylation of H4 Lysine 16. Nature communications 6, 8856 (2015)

10.    Lei Zhao*, Hai-Hui Gu*, Jian-Feng Chang*, Jun-Yu Wu, Da-Liang Wang, Su Chen, Xiao-Mei Yang Bao-Hua Qian （2014）MicroRNA-383 regulates the apoptosis of tumor cells through targeting Gadd45g. PLoS ONE 9(11): e110472.

11.    Fengfeng Cai, Ping Chen, Li Chen, Ewelina Biskup, Yan Liu, Pei-Chao Chen, Jian-Feng Chang, Wenjie Jiang, Yuanya Jing, Youwei Chen, Hui Jin, Su Chen （2014）Human RAD6 Promotes G1-S Transition and Cell Proliferation through Upregulation of Cyclin D1 Expression. PLoS ONE 9(11):e113727

12.    Jianfeng Chang, Xuanying Fu, Lizhe An, Jianhui Wang, Shijian Xu, Manxiao Zhang, Huyuan Feng, Tuo Chen. (2006) Properties of cellular ubiquinone and stress-resistance in suspension-cultured cells of Chorispora bungeana during early chilling. Environmental and Experimental Botany 57(1-2), 116-122

13.     Xuanying Fu, Jianfeng Chang, Lizhe An, Manxiao Zhang, Shijian Xu, Tuo Chen, Yanhong Liu, Hua Xin, Jianhui Wang. (2006) Association of the cold-hardiness of Chorispora bungeana distribution and accumulation of calcium in the cells   Environmental and Experimental Botany, 55(3), 282-293