姓        名：蒋颖

学  位：博士

研究领域：乳腺癌及妇科肿瘤相关基因组稳定性调控机制

研究方向：

（1）乳腺癌及妇科肿瘤相关DNA修复调控机制

（2）靶向DNA修复预防及治疗乳腺癌和妇科肿瘤的新方法的探索研究以胚胎干细胞和诱导多能干细胞为对象，研究定向神经细胞、心肌细胞等分化的分子机理

E-mail：ying_jiang@tongji.edu.cn

联系电话：021-65978116

通讯地址：上海市四平路1239号，同济大学生命科学与技术学院（200092）

教育及工作经历：

蒋颖，博士，副教授。2004年毕业于南京大学生命科学学院，获学士学位；2013年毕业于美国罗彻斯特大学生物系，获博士学位。2013年至今，先后担任同济大学生命科学与技术学院助理研究员、副研究员和副教授。

蒋颖副教授主要专注于女性相关肿瘤发生发展过程中DNA修复变化调控机制，利用多种独特的细胞和动物模型，关注重要女性肿瘤治疗靶点如PARP1等参与DNA修复的调控机制。围绕着该研究方向，蒋颖副教授现已在PNAS、Nucleic Acids Res.、Oncogene、JBC等重要学术期刊发表通讯、共同通讯、第一及共同第一作者论文10余篇。

代表性文章：

1. Wang C, Tang H, Geng A, Dai B, Zhang H, Sun X, Chen Y, Qiao Z, Zhu H, Yang J, Chen J, He Q, Qin N, Xie J, Tan R, Wan X, Gao S, Jiang Y^*, Sun FL^*, Mao Z^*. Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PKcs inhibitors.Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26356-26365. * Corresponding authors.

2. Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, SuT, ShiJ, Jiang C, Tian X, SeluanovA, HuangJ, WanX, Jiang Y^*, Gorbunova V^*,Mao Z^*.A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Res.2019 Jul 10. pii: gkz592. doi: 10.1093/nar/gkz592. * Corresponding authors. 

3. Zhang F, Tang H, Jiang Y^*,Mao Z^*. The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression. Oncogene. 2017 Sep 7;36(36):5168-5176. doi: 10.1038/onc.2017.127. * Corresponding authors.

4. Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y^*,Mao Z^*.Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy. Cell Death & Disease. 2018 Mar 16;9(4):420. doi: 10.1038/s41419-018-0453-9. * Corresponding authors.

5. Yu Y, Tang R, Ren Q, Gao B, Sheng Z, Zhang J, Zheng X, Jiang Y^*, Li Lan^*,Mao Z^*. POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions. Aging (Albany NY). 2017 Dec 8;9(12):2529-2543. * Corresponding authors.

6. Hu Z, Cai B, Wang M, Wen X, Geng A, Hu X, Xue R, Mao Z, Jiang Y^*, Wan X^*. Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer. Cell Cycle. 2020 Nov;19(22):3115-3126. * Corresponding authors.

7. Cai B, Hu Z, Tang H, Hu Z, Mao Z, Liu B, Xu X, Jiang Y^*, Wan X^*. Triptolide impairs genome integrity by directly blocking the enzymatic activity of DNA-PKcs in human cells. Biomed Pharmacother.2020 Sep;129:110427. * Corresponding authors.

8. Zhang L, Zhang F, Zhang W, Chen L, Gao N, Men Y, Xu X, Jiang Y^*. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92.* Corresponding author.

9. Jiang Y, Ding Q, Xie X, Libby RT, Lefebvre V, Gan L. Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells. J Biol Chem. 2013 Jun 21;288(25):18429-38.

10. Mao Z^#, Jiang Y^#, Liu X, Seluanov A, Gorbunova V. DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia.2009 Jul; 11(7):683-691. # These authors contributed equally to this work.