姓名：柏丹丹

学位：博士

导师情况：硕士生导师

研究领域：早期胚胎发育与干细胞重构类胚胎

E-mail：1810533@tongji.edu.cn

联系电话：19946253505

实验室主页：https://gaolab.tongji.edu.cn/main.htm

通讯地址：上海市杨浦区四平路同济大学东区，生命科学与创新创业大楼

邮编：200092

教育及工作经历：

2026.03-至今，  同济大学附属妇产科医院，副研究员

2025.06-2026.03，同济大学附属妇产科医院，助理研究员

2022.06-2025.05，同济大学，博士后

2018.09-2022.06，同济大学，生物学，博士

2015.09-2018.05，同济大学，生物学，硕士

2011.09-2015.06，山东第一医科大学，生物技术，本科

研究方向：

1、小鼠与人早期胚胎发育过程中的谱系建立与表观遗传调控机制

2、胚胎与类胚胎的体外延长培养技术

个人简介

柏丹丹，博士，副研究员。高绍荣院士、刘文强教授团队成员。聚焦早期胚胎发育研究，主要利用表观组、代谢组、蛋白组等多组学技术解析植入前配子到胚胎转换到植入后围着床期的谱系发育与命运转变的调控机制。相关研究发表于 Nature Cell Biology, Cell Reports, Protein & Cell, Cell Research, Aging Cell等杂志，主持国家自然科学基金青年项目（C类）、国家自然科学基金面上项目，博士后面上项目（结题）。曾获得上海市“超级博士后”资助，国家资助博士后研究计划B档资助，博士后科研业绩评估考核二档资助，沈沁纪念奖优秀学者称号。

代表性文章

1.Bai D*, Sun J*, Chen C, Jia Y, Li Y, Liu K, Zhang Y, Yin J, Liu Y, Han X, Ruan J, Kou X, Zhao Y, Wang H, Wang Z, Chen M, Teng X, Jiang C#, Gao S#, Liu W#. Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos. Cell Reports. 2022 May 3;39(5):110784.

2.Yang H*, Bai D*, Li Y*, Yu Z*, Wang C, Sheng Y, Liu W#, Gao S#, Zhang Y#. Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo. Nature Cell Biology. 2022 Apr 28.

3.Guo Y*, Bai D*, Liu W*, Liu Y, Zhang Y, Kou X, Chen J, Wang H, Teng X#, Zuo J#, Gao S#. Altered sperm tsRNAs in aged male contribute to anxiety-like behavior in offspring. Aging Cell. 2021 Sep; 20(9): e13466.

4.Bai D*, Sun J*, Jia Y*, Yin J, Zhang Y, Li Y, Gao R, Du X, Li K, Lin J, Tu Z, Wang Y, Pan J, Liang S, Guo Y, Ruan J, Kou X, Zhao Y, Wang H, Jiang C, Wang F, Teng X#, Liu W#, Gao S#. Genome transfer for the prevention of female infertility caused by maternal gene mutation. Journal of Genetics and Genomics. 2020 Jun 20;47(6):311-319.

5.Liu K*, Xu X*, Bai D*, Li Y, Zhang Y, Jia Y, Guo M, Han X, Liu Y, Sheng Y, Kou X, Zhao Y, Yin J, Wang H, Wang Y#, Liu W#, Gao S#. Bilineage embryo-like structure (BLES) formed by EPS cells can produce live mice with tetraploid trophectoderm. Protein Cell. 2023 Apr 21;14(4):262-278.

6.Xi C*, Yan Z*, Bai D*, Zhang Y*, Wang B*, Han X*, Wu L, Shi X, Hu Z, Tang M, Su Z, Liu Y, Liu B, Yin J, Wang H, Li X#, Zhang Y#, Gao S#, Liu W#. Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy. Protein Cell. 2024 May 28;15(6):460-473.

7.Liu YD*, Teng XM*, Bai DD*, Xing FY, Chang QR, Li JL, Gao SR#, Liu WQ#, Guo Y#. Inhibition of aging-induced DNA hypermethylation by si-Dnmt3a/3b in pre-implantation embryos improves aberrant social behavior in offspring. Int J Biol Macromol. 2025 Mar 17:142130.

8.Zhao Y*, Bai D*, Wu Y*, Zhang D, Liu M, Tian Y, Lu J, Wang H#, Gao S#, Lu Z#. Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse. Development. 2022 Aug 1;149(15): dev200316.

9. Liu K*, Yan Z*, Bai D*, Jiang R*, Bi Y*, Ma X*, Xiang J, Sheng Y, Dong B, Ning Z, Yi S, Liu Y, Lei X, Jia Y, Zhang Y, Zhang Y, Li Y, Wu T, Xi C, Liu S, Liu S, Chen J, Yin J, Kou X, Zhao Y, Wang H, Wang Y, Wei K, Gao S, Liu W. Modeling post-gastrula development via bidirectional pluripotent stem cells. Cell Res. 2025 Dec;35(12):954-969.