姓        名：薛任皓

学         位：博士

导师情况：硕士生导师

研究领域：衰老相关神经系统疾病

研究方向：

1. 细胞衰老的分子机制

2. 炎性衰老在神经系统疾病中的作用与机制

3. 老年性神经退行性疾病的缓解与治疗

E-mail：xuerenhao@tongji.edu.cn

联系电话：021-65988166

通讯地址：上海市浦东新区沪南路550号科研楼311室

个人简介:

薛任皓，副研究员，硕士生导师。2002、2005年先后毕业于南京大学生命科学学院，获学士和硕士学位；2009年毕业于新加坡南洋理工大学，获博士学位，于2009-2018年在新加坡科技研究局，美国霍华德休斯医学研究所等科研院所先后担任博士后、科研专员。于2020年起受聘同济大学附属第一妇婴保健院，任副研究员。主要关注于神经系统疾病机制及细胞衰老机制与老年性神经系统疾病的联系。于2020年入选上海市“浦江人才”人才计划。现已在PNAS、Nature Communications.、Frontiers in Molecular Neuroscience等重要学术期刊发表等重要学术期刊发表通讯、共同通讯、第一及共同第一作者论文10余篇。曾担当Brain Science等学术期刊客座编辑、审稿人。当前正在主持国家自然科学基金与上海市自然科学基金面上项目各一项。

代表性文章：

1. Qin N, Chen Z, Xue R*. A two-subpopulation model that reflects heterogeneity of large dense core vesicles in exocytosis. Cell Cycle. 2022; Online. DOI: 10.1080/15384101.2022.2026576

2. Qin N, Geng A, Xue R*. Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases. Aging Dis. 2021; Online. DOI: 10.14336/ad.2021.1212

3. Xue R*, Meng H, Yin J, Xia J, Hu Z, Liu H*. The Role of Calmodulin vs. Synaptotagmin in Exocytosis. Front Mol Neurosci. 2021;14691363.

4. Xue R, Ruhl DA, Briguglio JS, Figueroa AG, Pearce RA, Chapman ER*. Doc2-mediated superpriming supports synaptic augmentation. Proc Natl Acad Sci USA. 2018;115(24):E5605.

5. Bai H#, Xue R#, Bao H, Zhang L, Yethiraj A, Cui Q, Chapman ER*. Different states of synaptotagmin regulate evoked versus spontaneous release. Nat Commun. 2016;710971.

6. Xue R#, Gaffaney JD#, Chapman ER*. Structural elements that underlie Doc2 beta function during asynchronous synaptic transmission. Proc Natl Acad Sci USA. 2015;112(31):E4316.

7. Liu H#, Bai H#, Xue R, Takahashi H, Edwardson JM, Chapman ER*. Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission. Nat Neurosci. 2014;17(5):670.

8. Gaffaney JD#, Xue R#, Chapman ER*. Mutations that disrupt Ca2+-binding activity endow Doc2 beta with novel functional properties during synaptic transmission. Mol Biol Cell. 2014;25(4):481.

9. Zhang J#, Xue R#, Ong W-Y, Chen P*. Roles of Cholesterol in Vesicle Fusion and Motion. Biophys J. 2009;97(5):1371.

10. Xue R, Zhao Y, Su L, Ye F, Chen P*. PKC epsilon facilitates recovery of exocytosis after an exhausting stimulation. Pfluegers Arch. 2009;458(6):1137.

11. Xue R, Zhao Y, Chen P*. Involvement of PKC alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells. Biochem Biophys Res Commun. 2009;380(2):371.

12. Xue R, Cao D, Zheng W, Sun L, Liu Z*. Protective effects of ethyl docosahexaenoate on brain oxidative injury and edema induced by cerebral ischemic reperfusion. Chinese Journal of Marine Drugs. 2004;23(5):21-5.

* 通讯作者，#并列第一作者