姓        名：贾文文

学         位：博士

研究领域：细胞生物学

研究方向：

（1）以胚胎干细胞和诱导多能干细胞为对象，研究定向神经细胞、心肌细胞等分化的分子机理；

（2）临床级间充质干细胞规模化、自动化扩增工艺研究。                           

E-mail：wuj3@tongji.edu.cn

联系电话：021-65988876

通讯地址：上海市四平路1239号，同济大学生命科学与技术学院（200092）

个人简介：

贾文文，同济大学，副教授/博士生导师，现为国家干细胞转化资源库副主任，上海干细胞临床转化研究院研究员。长期从事临床级iPSC、成体干细胞制备、质检、临床转化以及干细胞药物申报等方面的工作。担任中国中西医结合学会第一届干细胞与再生医学专业委员会青年委员副主委、中国整形美容协会干细胞研究与应用分会第二届理事会常务理事等职。发表SCI论文40余篇。授权干细胞相关专利17项。主持国家自然科学基金3项，国家重点研发计划课题组长项目1项，子课题3项。作为主要起草人制定并发布干细胞相关行业标准、团体标准、规范5项。

发表论文： 

（1）Lu J, Zhang L, Cao H, Ma X, Bai Z, Zhu H, Qi Y, Zhang S, Zhang P, He Z, Yang H*, Liu Z*, Jia W*. The Low Tumorigenic Risk and Subtypes of Cardiomyocytes Derived from Human-induced Pluripotent Stem Cells. Curr Stem Cell Res Ther. 2025;20(3):317-335. （*共同通讯）

（2）Wang X#, Yang C#, Ma X, Li X, Qi Y, Bai Z, Xu Y, Ma K, Luo Y, Song J, Jia W*, He Z*, Liu Z*. A division-of-labor mode contributes to the cardioprotective potential of mesenchymal stem/stromal cells in heart failure post myocardial infarction. Frontiers in Immunology. 2024 Mar 18;15:1363517. (*共同通讯)

（3）Qi Y#, Wang X#, Bai Z, Xu Y, Lu T, Zhu H, Zhang S, Wu Z, Liu Z*, He Z*, Jia W*. Enhancement of the function of mesenchymal stem cells by using a GMP-grade three-dimensional hypoxic large-scale production system. Heliyon. 2024 May 18;10(10):e30968.(*共同通讯)

（4）Aierken A, Li B, Liu P, Cheng X, Kou Z, Tan N, Zhang M, Yu S, Shen Q, Du X, Enkhbaatar BB, Zhang J, Zhang R, Wu X, Wang R, He X, Li N, Peng S, Jia W*, Wang C*, Hua J*. Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway. Stem Cell Res Ther. 2022 Apr 12;13(1):164. （*共同通讯）

（5）Wang X; Qi Y; Hu Z; Jiang L; Pan F; Xiang Z; Xiong Z; Jia W*; Hu J; Lu W*; Fe3O4@PVP@DOX magnetic vortex hybrid nanostructures with magnetic-responsive heating and controlled drug delivery functions for precise medicine of cancers, Advanced Composites and Hybrid Materials, 2022, 4(4).（*共同通讯）

（6）Jia W#; Lu J#; Zhang L; Cao H; Qi Y; Zhu H; Bai Z; Zhang S; Qiao Z; Bao Y; Liu Z; An induced pluripotent stem cell line (EHTJUi003-A) generated from a neonate with c.1377delC mutation in the gene MYBPC3 causing hypertrophic cardiomyopathy, Stem Cell Research, 2021, 53: 0-102328.（#共同一作）

（7）Lu J#; Qiao Z#; Zhang L; Cao H; Bai Z; Qi Y; Zhu H; Chen Y; Zhang S; Yan X; Bao Y; Jia W*; Liu Z; Generation of a laminopathies-specific iPSC line EHTJUi005-A-3 with homozygous knockout of the LMNA gene by CRISPR/Cas9 technology, Stem Cell Research, 2021, 56(N/A): 0-102530.（*共同通讯）

（8）Qiao Z#; Lu J#; Zhang L; Cao H; Bai Z; Qi Y; Zhu H; Zhang S; Bao Y; Jia W*; Liu Z; CRISPR/Cas9 mediated generation of a iPSC line EHTJUi005-A-1 with homozygous knockout of the SUV39H1 gene, Stem Cell Research, 2021, 56(N/A): 0-102519.（*共同通讯）

（9）Qi Y; Lu J; Zhang L; Cao H; Zhu H; Bai Z; Zhang S; Qiao Z; Jia W*; Liu Z; An induced pluripotent stem cell line (EHTJUi004-A) generated from a neonate with c.4683_4684delCT:p.Leu1563fs mutation in the gene DSP causing Familial Arrhythmogenic Right Ventricular Dysplasia (ARVD), Stem cell Research, 2021, 53(102369): 1-4.（*共同通讯）

（10）Jia W#; Qi Y#; Hu Z#; Xiong Z; Luo Z; Xiang Z; Hu J; Lu W; Facile and green fabrication of monodisperse CoFe2O4 nanocrystals for magnetic-responsive on-demand cancer theranostic applications, Advanced Composites and Hybrid Materials, 2021, 41: 1-13.（#共同一作）

（11）Lu J; Zhang L; Zhu H; Qi Y; Bai Z; Jia W*; Liu Z*; An induced pluripotent stem cell line (EHTJUi002-A) derived from a neonate with c.678G > A mutation in the gene FZD4 causing exudative vitreoretinopathy, Stem Cell Research, 2020, 48(N/A): 0 -101932.（*共同通讯）

（12）Xiang Z; Qi Y; Lu Y; Hu Z; Wang X; Jia W*; Hu J; Ji J; Lu W; MOF-derived novel porous Fe3O4@C nanocomposites as smart nanomedical platforms for combined cancer therapy: magnetic-triggered synergistic hyperthermia and chemotherapy, Journal of Materials Chemistry B, 2020, 8(37): 8671-8683.（*共同通讯）

（13）Zhou HM; Zhou XQ; Lu JZ; Jia WW*; Kang JH*; An induced pluripotent stem cell line (SHEHi002-A (5426))from a patient of long QT syndrome type 8 with c.2573G>A mutation in the gene CACNA1C. Stem Cell Res, 2020; 43:101731.（*共同通讯）

（14）Yu Y, Jia WW*, Lyu Y, Su D, Bai M, Shen J, Qiao J, Han T, Liu W, Chen J, Chen W, Ye D, Guo X, Zhu S, Xi J, Zhu R, Wan X, Gao S, Zhu J; Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation, Cell Discovery, 2019, 5(1) .（*共同通讯）

(15)Wei T, Jia W*, Qian Z, Zhao L, Yu Y, Li L,Wang C, Zhang W, Liu Q, Yang D, Wang G, Wang Z, Wang K, Duan T, Kang J.Folic Acid Supports Pluripotency and Reprogramming by Regulating LIF/STAT3 and MAPK/ERK Signaling. Stem Cells Dev, 2016; 26(1):49-59.( *共同通讯）

（16） Shen J#, Jia W#, Yu Y, Chen J, Cao X, Du Y,Zhang X,Zhu S, Chen W, Xi J,Wei  T, Wang G,Yuan D,Duan T,Jiang C*,Kang J*. Pwp1 Is Required for the Differentiation Potential of Mouse Embryonic Stem Cells through Regulating Stat3 Signaling. Stem Cells, 2015;33(3):661-73, (#共同一作)

（17）Luo C#, Jia W#, Wang K, Chi F, Gu Y, Yan X, Zou G, Duan T*, Zhou Q*. Human Amniotic Fluid Stem Cells Suppress PBMC Proliferation through IDO and IL-10-Dependent Pathways. Curr Stem Cell Res Ther, 2014; 9(1):36-45.( #共同一作)

（18） Jia W#, Chen W#, Kang J*. The functions of microRNAs and long non-coding RNAs in embryonicand induced pluripotent stem cells. Genomics Proteomics Bioinformatics, 2013; 11(5):275-83. (#共同一作)

（19）Chen W#, Jia W#,Wang K, Zhou Q,Leng Y, Duan T, Kang J*. Retinoic acid regulates germ cell differentiation in mouse embryonic stem cells through a Smad-dependent pathway. Biochem Biophys Res Commun, 2012;418(3):571-7. (#共同一作)

（20）Jia W#, Wang S#, HornerJ, Wang N, Wang H, Gunther E, DePinho R, Zhu J*. A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis. The FASEB Journal, 2011;25(3):979-89. (#共同一作)

（21）Jia W,Cheng D,Chen S,Lei L,Wang H*.Retinoic Acid Induces Myoblasts Transdifferentiation Into Premeiotic Stra8-Positive Cells. Cell Biol Int, 2011;35(4):365-72. (#共同一作)

（22）Mathew R#, Jia W#, Sharma A, Zhao Y, Clarke L, Cheng X, Wang H, Salli U, Vrana K, Robertson G, Zhu J, Wang S*. Robust activation of the human but not mouse telomerase gene during the induction of pluripotency. The FASEB Journal, 2010;24(8):2702-15. (#共同一作)

（23）Jia W, Yang W#, Lei A, Gao Z, Yang C, Hua J, Huang W, Ma X, Wang H*, Dou Z*. A caprine chimera produced by injection of embryonic germ cells into a blastocyst. Theriogenology, 2008;69(3):340-348. (#第一作者)