姓名：刘默芳

学位：博士

导师情况：博士生导师

研究领域：RNA调控与男性生殖健康

E-mail：mfliu@tongji.edu.cn

通讯地址：上海市四平路1230号，同济大学东校区A楼;同济大学生命科学与技术学院（200092）

个人简介：

分别于1991年、1994年在华东理工大学获学士、硕士学位，2000年在中科院上海生物化学研究所获博士学位。分别于2000-2005年、2005-2006年在美国国家健康研究院癌症研究所 (National Cancer Institute, NIH)博士后研究、约翰霍浦金斯医学院遗传和分子生物学系任研究助理。2006-2026，中科院上海生化细胞所研究员，先后担任co-PI、RNA研究技术平台主任、研究组长；2026-至今，同济大学生命科学与技术学院长聘特聘教授。

先后入选新基石研究员、国家杰出青年科学基金、国家“万人计划”科技创新领军人才、国家百千万人才工程、东方英才团队等人才项目，主持科技部重点研发计划等项目，现任《中国科学:生命科学》副主编、中国生化与分子生物学会RNA专业委员会主任，担任Cell Research、Journal of Biological Chemistry、Biology of Reproduction等期刊编委。

在研项目情况：

1) 国家自然科学基金委基础科学中心项目A类。项目名称：精子发生与早期胚胎发育调控及出生缺陷病因研究；起止年月：2025年01月-2029年12月；学术骨干：刘默芳。

2) 新基石研究员项目。项目名称：精子发生关键调控机制及男性不育新病因研究；起止年月：2024年01月-2028年12月；项目负责人：刘默芳。

3) 上海市科委基础研究领域重点项目。项目名称：RNA调控在精子形成及男性不育中的新功能机制研究；起止年月：2023年12月-2026年11月；项目首席科学家：刘默芳。

4) 国家自然科学基金委重点项目。项目名称：功能性piRNA鉴定及piRNA调控规则研究；起止年月：2024年1月-2028年12月；项目负责人：刘默芳。

5) 上海市东方英才团队项目。项目名称：RNA调控与男性生殖健康；2024年01月-2027年12月；项目负责人：刘默芳。

6) 国家重点研发计划“生物大分子与微生物组” 重点专项项目。项目名称：非编码RNA及其非经典翻译的功能机制；学术骨干：刘默芳。

主要科研奖励：

1)2026年度发展中国家科学院（TWAS）生物学奖

2)2026年度中国细胞生物学学会杰出成就奖

3)2023年度新基石研究员项目

4)2022年度上海市自然科学奖一等奖

5)2020年国家“十三五”蛋白质专项5项重大成果之一

6)2019年度全国妇幼健康科学技术奖自然科学奖一等奖

7)2018年度谈家桢生命科学创新奖

8)2018年度上海市巾帼创新奖

9)2017年度中国生命科学十大进展

10)2017年度和2019年度中国科学院科技创新亮点成果

代表性论文：

1) Du Q, Wang X, Wang YM, Liu MF*, Cao XF*. Empowering Drug Innovation Through Fundamental RNA Research in China. Nat Chem Biol, accepted.

2) Pan D, Liu MF*. tRNA intron-derived small regulatory RNAs fine-tune gene expression under oxidative stress. Mol Cell, 2025, 85(4): 669-671.

3) Guang S, Liu MF*. The discovery of tiny RNAs that have crucial roles. Sci China Life Sci, 2025, 68(4):1183-1185. 

4) Wei H, Gao J, Lin DH, Geng R, Liao J, Huang TYu, Shang Guan, Jing J, Fan ZW, Pan D, Yin ZQ, Li T, Liu X, Chen C, Li J, Wang X*, Ding D*, Liu MF*. piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis. Nat Commun, 2024, 15(1): 2343.

5) Wang X*, Zhang ZY, Zhao S, Liu MF*. New insights into small non-coding RNAs during spermatogenesis. Sci Bull (Beijing), 2024, 69(11): 1581-1585.

6) Wu K, Bu F, Wu Y, Zhang G, Wang X, He S, Liu MF*, Chen R*, Yuan H*. Exploring noncoding variants in genetic diseases: From detection to functional insights. J Genet Genomics, 2024, 51(2): 111-132.

7) Zhang Y, Kang JY, Liu MF*, Huang Y*. Diverse roles of biomolecular condensation in eukaryotic translational regulation, RNA Biol, 2023, 20(1): 893-907.

8) Wang X, Lin DH, Yan Y, Wang AH, Liao J, Meng Q, Yang WQ, Zuo H, Hua MM, Zhang F, Zhu H, Zhou H, Huang TY, He R, Li G, Tan YQ, Shi HJ, Gou LT, Li D, Wu L, Zheng Y, Fu XD, Li J, Liu R*, Li GH*, Liu MF*. The PIWI-specific Insertion Module Helps Load Longer piRNAs for Translational Activation Essential for Male Fertility. SCI CHINA Life Sci, 2023, 66(7): 1460-1481. Published as a Cover story and companied by a Previews in the same issue.

9) Kang JY, Zhong A, Wen Z, Yu X, Zhou Y, Liu MF*. Polysome Profiling in Adult Mouse Testes. Bio Protoc, 2023, 13(11): e4686.

10) Zhao MN, Zhang LF, Sun Z, Qiao LH, Yang T, Ren YZ, Zhang XZ, Wu L, Qian WL, Guo QM, Xu WX, Wang XQ, Wu F, Wang L, Gu Y*, Liu MF*, Lou JT*. A novel microRNA-182/Interleukin-8 regulatory axis controls osteolytic bone metastasis of lung cancer. Cell Death Dis 2023,14(5): 298.

11) Wang X, Ramat A, Simonelig M*, Liu MF*. Emerging roles and functional mechanisms of PIWI-interacting RNAs. Nat Rev Mol Cell Biol, 2023, 24(2): 123-141.

12) Kang JY, Wen Z, Pan D, Zhang Y, Li Q, Zhong A, Yu X, Wu YC, Chen Y, Zhang X, Kou PC, Geng J, Wang YY, Hua MM, Zong R, Li B, Shi HJ, Li D, Fu XD, Li J, Nelson DL, Guo X, Zhou Y, Gou LT, Huang Y*, and Liu MF*. LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs. Science, 2022, 377(6607): eabj6647. Companied by a Perspective in the same issue.

13) Wang X, Ramat A, Simonelig M*, and Liu MF*. Emerging roles and functional mechanisms of PIWI-interacting RNAs. Nat Rev Mol Cell Biol, in press.

14) Wang X, Tan YQ*, and Liu MF*. Defective piRNA Processing and Azoospermia. N Engl J Med, 2022, 386(17):1674-1675.

15) Zhao MZ, Lin DH, Zuo H, Wei H, Wang X*, Gou LT*, and Liu MF*. piRNA 3' uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells. Cell Res, 2022 Apr 15. doi: 10.1038/s41422-022-00659-1. Online ahead of print.

16) Wang X, Gou LT*, and Liu MF*. Noncanonical Functions of PIWIL1/piRNAs in animal male germ cells and human diseases. Biol Reprod, 2022 107(1):101-108.

17) Cong J, Yang Y, Wang X, Shen Y, Qi HT, Liu C, Tang S, Wu S, Tian S, Zhou Y, He X, Wang L*, Liu MF*, Zhang F*. Deficiency of X-linked TENT5D causes male infertility by disrupting the mRNA stability during spermatogenesis. Cell Discov, 2022, 8(1):23.

18) Li F, Yuan P, Rao M, Jin CH, Tang W, Rong YF, Hu YP, Zhang F, Wei T, Yin Q, Liang T, Wu L, Li J, Li D, Liu Y, Lou W, Zhao S*, Liu MF*. piRNA-independent Function of PIWIL1 as a Co-activator for Anaphase Promoting Complex/Cyclosome to Drive Pancreatic Cancer Metastasis. Nat Cell Biol, 2020, 2020, 22(4):425-438. Companied by a News and Views in the same issue.

19) Wang X, Li ZT, Yan Y, Lin P, Tang W, Hasler D, Meduri R, Li Y, Hua MM, Qi HT, Lin DH, Shi HJ, Hui J, Li J, Li D, Yang JH, Lin J, Meister G, Fischer U, Liu MF*. LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. Mol Cell, 2020, 77:999-1013. Published as a Cover story and companied by a Previews in the same issue.

20) Dai P, Wang X, Gou LT, Li ZT, Wen Z, Chen ZG, Hua MM, Zhong A, Wang L, Su H, Wan H, Qian K, Liao L, Li J, Tian B, Li D, Fu XD, Shi HJ*, Zhou Y*, Liu MF*. Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis. Cell, 2019, 179:1566-1581. Highlighted by Nat Rev Mol Cell Biol；Recommended by F1000Prime；入选2019年中科院科技创新亮点成果.

21) Dai P, Wang X, Liu MF*. A dual role of the PIWI/piRNA machinery in regulating mRNAs during mouse spermiogenesis. Sci China Life Sci, 2020, 63: 447-449. 

22) Wang X, Kang JY, Wei L, Yang X, Sun H, Yang S, Lu L, Yan M, Bai M, Chen Y, Long J, Li N, Li D, Huang J, Lei M, Shao Z, Yuan W, Zuo E, Lu K*, Liu MF*, Li J*. PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis. Development. 2019,146: dev175547.

23) Gou LT, Kang JY, Dai P, Wang X, Li F, Zhao S, Zhang M, Hua MM, Lu Y, Zhu Y, Li Z, Chen H, Wu LG, Li D, Fu XD, Li J, Shi HJ*, Liu MF*. Ubiquitination-deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell, 2017,169:1090-1104. Highlighted by Nat Rev Urol and Reprod Biol; 入选2017年中国生命科学十大进展、中科院科技创新亮点成果.

24) Zhang LF, Jiang S*, Liu MF*. MicroRNA regulation and analytical methods in cancer cell metabolism. Cell Mol Life Sci, 2017, 74:2929-2941.

25) Yuan P, He XH, Rong YF, Cao J, Li Y, Hu Y, Liu Y, Li D, Lou W*, Liu MF*. KRAS-NFκB-YY1-miR-489 signaling axis controls pancreatic cancer metastasis. Cancer Res, 2017, 77:100-111.

26) He XH, Zhu W, Yuan P, Jiang S, Li D, Zhang HW, MF Liu*. miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells. Oncogene, 2016, 35:6015-6025.

27) Zhang LF, Lou JT, Lu MH, Gao C, Zhao S, Li B, Liang S, Li Y, Li D, Liu MF*.  Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma. EMBO J, 2015, 34:2671-2685.

28) Zhang P, Kang JY, Gou LT, Wang J, Xue Y, Skogerboe G, Dai P, Huang DW, Chen R, Fu XD*, Liu MF^*, He S*. MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes. Cell Res, 2015, 25:193-207.

29) Wang L, Zhang LF, Wu J, Xu SJ, Xu YY, Li D, Lou JT*, Liu MF*. IL-1β-mediated repression of microRNA-101 is crucial for inflammation-promoted lung tumorigenesis. Cancer Res, 2014, 74:4720-4730.

30) Gou LT, Dai P, Liu MF*. Small non-coding RNAs and male Infertility. WIREs RNA, 2014, 5:733-745.

31) Gou LT, Dai P, Yang JH, Xue Y, Hu YP, Zhou Y, Kang JY, Wang X, Li H, Hua MM, Zhao S, Hu SD, Wu LG, Shi HJ, Li Y, Fu XD, Qu LH, Wang ED, Liu MF*. Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis. Cell Res, 2014, 24:680-700. Published as a Cover story, highlighted by Cell Res; 入选中国科协“生命科学与基础医学10篇优秀论文”.

32) Hu S, Zhu W, Zhang LF, Pei M, Liu MF*. MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer. Cell Res, 2014, 24:254-257.

33) Zhao S, Gou LT, Zhang M, Zu LD, Hua MM, Hua Y, Shi HJ, Li Y, Li JS, Li DS, Wang ED*, Liu MF*. piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis. Dev Cell, 2013, 24:13-25. Highlighted by Dev Cell and Asian J Androl.

34) Qiao M, Zu LD, He XH, Shen RL, Wang QC, Liu MF*.  Onconase down-regulates microRNA expression through targeting microRNA precursors. Cell Res, 2012, 22:1199-202.

35) Jiang S, Zhang LF, Zhang HW, Hu S, Lu MH, Liang S, Li B, Li Y, Li D, Wang ED, Liu MF*. A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase2 in breast cancer cells. EMBO J, 2012, 31:1985-1998.

36) Jiang S, Zhang HW, Lu MH, He XH, Li Y, Gu H, Liu MF*, Wang ED. MicroRNA-155 functions as an oncomiR in breast cancer by targeting the suppressor of cytokine signaling-1 gene. Cancer Res, 2010, 70: 3119-3127.

37) Zhao S, Liu MF*. Mechanisms of miRNA-mediated gene regulation. Sci China C Life Sci, 2009, 52:1111-1116.