姓名：徐小翠

学位：博士

导师情况：博士生导师

研究领域：生物信息学与表观遗传调控

导师情况：博士生导师

E-mail：xiaocuixu@tongji.edu.cn

实验室网址：https://gaolab.tongji.edu.cn/main.htm

研究方向：

1. 干细胞与胚胎发育的表观调控机制

2. 多组学数据整合与算法开发

招生方向：

1. 遗传与表观遗传学

2. 生物信息与人工智能

个人简介：

2007.9-2011.6      中国医科大学  生命科学与技术专业  学士

2011.9-2019.6      中国科学院  北京基因组研究所  博士

2019.9-2020.4       同济大学生命科学与技术学院  助理研究员

2020.5-2023.2      同济大学 生命科学与技术学院  博士后

2023.3至今         同济大学 生命科学与技术学院  预聘副教授

   徐小翠，女，遗传学博士，同济大学生命科学与技术学院预聘副教授。多年来一直从事胚胎发育和干细胞分化过程中的数据挖掘工作，开发生物信息学的算法，阐明细胞命运的表观调控，主要通过整合多组学高通量数据包括DNA甲基化、组蛋白修饰、RNA甲基化和转录组数据等，深入挖掘胚胎发育过程中细胞状态转变及命运决定的表观遗传学调控机制，相关研究成果发表在Nature Cell Biology、National Science Review、Protein Cell等权威学术期刊。未来的研究方向包括应用机器学习方法挖掘全基因组学数据，基于单细胞转录组学、空间转录组学数据和单细胞表观组学数据，系统研究发育分化过程中细胞的交互作用关系。

承担科研项目情况：

1. 小鼠受精卵父母源DNA甲基化重编程的分子机制研究，国家自然科学基金委青年项目，2021.01-2023.12，24万，主持

2. 小鼠受精卵父母源DNA的5hmC重编程过程和机制的研究，中国博士后科学基金面上资助，2021.06-2023.05，8万，主持

3. 组蛋白修饰在小鼠胚胎和类囊胚滋养外胚层谱系分化中的作用机制研究, 国家自然科学基金委面上项目，2023.01-2026.12，54万，主持

4. 代谢失调对胚胎异常发育的影响及机制,重点研发, 2023.12-2028.11, 154万，项目骨干

代表性论文

(#共同一作，*共同通讯)

1.Bo Jiang#, Wenhui Xing#, Xiaocui Xu#, Shuqin Chen#, Heng Feng, Rui Shao, Jiatong Sun, Yazhuo Zhang, Zaiqi Xie,Wenxiang Wang, Xubin Yin, Yi Wang, Miaomiao Wang, Ling Li, Zhong Zhang, Bo Gao, Jinlong Suo, Xuye Hu, Lijun Wang,Jun Sun, Bin Zhou, Bo O. Zhou, Matthew B. Greenblatt, Rongrong Le*, Weiguo Zou*,Fibrous-layer resident Angptl7+ periosteal stem cells sense injury inflammation to orchestrate fracture repair, Cell Research(2026).

2. Yiliang Xu, Tao Cheng, Jianzhang Wang, Zhiruo Qiu, Xiaohong Guan, Yayuan Yu, Jiacheng Shen, Fangfang Xu, Xiaohong Jiang, Dandan Bai, Mingzhu Wang, Shuyan Mei, Hong Wang, Xiaocui Xu*, Li Wu*, Shaorong Gao*, Xuan Che*,Decoding Adenomyosis Pathogenesis Using an Assembloid Model, Science China Life Sciences(2025).

3. Zhongqu Su#, Yu Dong#, Jiatong Sun, You Wu, Qingqing Wei, Yuwei Liang, Zhiyi Lin, Yujun Li, Lu Shen, Chenxiang Xi, Li Wu, Yiliang Xu, Yingdong Liu, Jiqing Yin, Hong Wang, Kerong Shi, Rongrong Le*, Shaorong Gao*, Xiaocui Xu*, RNA m6A modification regulates cell fate transition between pluripotent stem cells and 2-cell-like cells, Cell Proliferation(2024).

4. Tao Chen#, Yiliang Xu#, Xiaocui Xu#, Jianzhang Wang#, Zhiruo Qiu, Yayuan Yu, Xiaohong Jiang, Wanqi Shao, Dandan Bai, Mingzhu Wang, Shuyan Mei, Tao Cheng, Li Wu*, Shaorong Gao*, Xuan Che*，Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics, Protein & Cell(2024).

5. Kuisheng Liu#, Xiaocui Xu#, Dandan Bai#, Yanhe Li, Yalin Zhang, Yanping Jia, Mingyue Guo, Xiaoxiao Han, Yingdong Liu, Yifan Sheng, Xiaochen Kou, Yanhong Zhao, Jiqing Yin, Sheng Liu, Jiayu Chen, Hong Wang, Yixuan Wang*, Wenqiang Liu*, Shaorong Gao*，Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm，Protein & Cell, pwac029（2023). 

6. You Wu#, Xiaocui Xu#, Meijie Qi#, Chuan Chen, Mengying Li, Rushuang Yan, Xiaochen Kou, Yanhong Zhao, Wenqiang Liu, Yanhe Li, Xuelian Liu, Meiling Zhang, Chengqi Yi, Hongbin Liu, Junhong Xiang, Hong Wang, Bin Shen*, Yawei Gao*, Shaorong Gao*, N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition, Nature Cell Biology  24, 917–927 (2022).

7. Lingyue Yang#, Xiaocui Xu#, Ruimin Xu, Chuan Chen, Xiaolei Zhang, Mo Chen, Xiaochen Kou, Yanhong Zhao, Hong Wang, Xiaoyu Liu*, Shaorong Gao*, Chong Li*，Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq，Stem Cell Reports，17(7):1730-1742（2022).

8. Xiaocui Xu#; Guoqiang Li#; Congru Li#; Jing Zhang#; Qiang Wang#; David K. Simmons; Xuepeng Che n; Naveen Wijesena; Wei Zhu; Zhanyang Wan; Zhenhua Wan; Bao Ju; Weimin Ci; Xuemei Lu; Daqi Yu; Qi an-fei Wang; Neelakanteswar Aluru; Paola Oliveri; Yong E. Zhang; Mark Q. Martindale; Jiang Liu* ; Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis, National Science Review, 2019, 6(5): 993-1003.

9. Congru Li#; Yong Fan#; Guoqiang Li#; Xiaocui Xu#; Jialei Duan; Rong Li; Xiangjin Kang; Xin Ma; Xuepeng Chen; Yuwen Ke; Jie Yan; Ying Lian; Ping Liu; Yue Zhao; Hongcui Zhao; Yaoyong Chen; Yan g Yu*; Jiang Liu*; DNA methylation reprogramming of functional elements during mammalian embryonic development, Cell Discovery, 2018, 4(41).