姓名：王冕

学位：博士

导师情况：博士生导师

研究领域：3D生物打印与器官构建，组织再生

E-mail：mianwang@tongji.edu.cn

通讯地址：上海市杨浦区四平路1239号，同济大学生命科学与技术学院

招生要求：热爱科研，不畏困难，主动沟通，有探索精神和团队意识。

研究方向：

1. 结合干细胞分化构建功能性仿生软组织

2. 3D生物打印技术的开发

3. 功能性水凝胶复合微纳米药物进行组织再生的研究

个人简介：

2011年本科毕业于山东大学，后分别在美国George Washington University（2013）和Northeastern University（2017）获得硕士、博士学位，2018-2021年在哈佛大学医学院进行博士后研究。主要研究方向为3D生物打印与器官构建，3D生物打印，微/纳米药物控释载体及具有药物缓释功能的组织工程支架的研发。2022年7月起任同济大学生命科学与技术学院“百人计划”特聘研究员，博士生导师，入选上海市浦江人才，主持和参与国家自然科学基金，科技部重点研发计划（项目骨干）等项目。目前已发表SCI论文40余篇，以第一/通讯作者身份在Advanced Materials, Nature Communications, Advanced Functional Materials等国际主流期刊发表论文21篇，已授权国际发明专利 1 项。担任International Journal of Nanomedicine (IF=7.033) 杂志副主编和Journal of Molecular Sciences, Bioengineering, Frontiers in Physiology等多个杂志的特邀编辑。

本课题组常年招聘博士后、研究生和科研助理，欢迎博士生、硕士生和本科生报考和实习。

代表性论文（#Co-first author, * Corresponding author）

一作/通讯作者文章：

1. Mian Wang, Wanlu Li, Jin Hao, Arthur Gonzales III, Xuan Mu, Terry Ching, Guosheng Tang, Zeyu Luo, Carlos Ezio Garciamendez Mijares, Michael Wells, Gengle Niu, Prajwal Agrawal, Alfredo Quinones-Hinojosa, Kevin Eggan, Yu Shrike Zhang*. Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues. Nature Communications, 2022,13: 3317.

2. Mian Wang, Wanlu Li, Luis S Mille, Terry Ching, Zeyu Luo, Guosheng Tang, Carlos Ezio Garciamendez, Ami Lesha, Michinao Hashimoto, Yu Shrike Zhang*. Digital Light Processing-Based Bioprinting with Composable Gradients. Advanced Materials, 2021, e2107038. （封面文章）

3. Wanlu Li#, Mian Wang#, Luis Santiago Mille, Juan Antonio Robledo Lara, Valentín Huerta, Tlalli Uribe Velázquez, Feng Cheng, Hongbin Li, Jiaxing Gong, Terry Ching, Caroline A Murphy, Ami Lesha, Shabir Hassan, Tim BF Woodfield, Khoon S Lim, Yu Shrike Zhang*. A Smartphone‐Enabled Portable Digital Light Processing 3D Printer. Advanced Materials, 2021, 2102153. （内封文章）

4. Mian Wang, Gujie Mi, Di Shi, Nicole Bassous, Daniel Hickey, Thomas J Webster*. Nanotechnology and nanomaterials for improving neural interfaces. Advanced Functional Materials, 2018, 12, 1700905.

5. Mian Wang, Wanlu Li, Guosheng Tang, Carlos Ezio Garciamendez Mijares, Yu Shrike Zhang*, Engineering (Bio) Materials through Shrinkage and Expansion. Advanced Healthcare Materials, 2021, 6, 2100380.

6. Hongbin Li, Jiliang Dai, Zixuan Wang, Heshan Zheng, Wanlu Li*, Mian Wang*, Feng Cheng*. Digital light processing (DLP)-based (bio)printing strategies for tissue modeling and regeneration. Aggregate, 2022, e270.

7. Mian Wang#, Wanlu Li#, Zeyu Luo, Guosheng Tang, Xuan Mu, Jie Guo, Liming Lian, Julia Olga Japo, Amir M. Ghaemmaghami, Yu Shrike Zhang*. A Multifunctional Pore-Forming Bioink with Enhanced Anti-Bacterial and Anti-Inflammatory Properties. Biofabrication, 2022, 14(2): 024105.

8. Xinsheng Qin#, Mian Wang#, Wanlu Li, Yu Shrike Zhang, Biosurfactant-Stabilized Micropore-Forming GelMA Inks Enable Improved Usability for 3D Printing Applications. Regenerative Engineering and Translational Medicine, 2022, 1-11.

9. Mian Wang, Yuanfeng Xin, Hao Cao, Wanlu Li, Yifei Hua, Thomas J Webster, Chao Zhang*, Wenjie Tang*, Zhongmin Liu*. Recent advances in mesenchymal stem cell membrane-coated nanoparticles for enhanced drug delivery. Biomaterials science, 2021, 2021,9, 1088-1103. （内封文章）

10. Mian Wang, Yangfang Zhou, Di Shi, Run Chang, Junyan Zhang, Michael Keidar, Thomas J Webster*. Cold atmospheric plasma (CAP)-modified and bioactive protein-loaded core–shell nanofibers for bone tissue engineering applications. Biomaterials science, 2019, 7, (6): 2430-2439.

11. Mian Wang, Pelagie Favi, Xiaoqian Cheng, Negar H Golshan, Katherine S Ziemer, Michael Keidar, Thomas J Webster*. Cold Atmospheric Plasma (CAP) Surface Nanomodified 3D Printed Polylactic Acid (PLA) Scaffolds for Bone Regeneration. Acta Biomaterialia, 2016, 12, 46: 256-265.

12. Mian Wang, Amit K Roy, Thomas J Webster*. Development of Chitosan/Poly (vinyl alcohol) Electrospun Nanofibers for Improved Wound Healing. Frontiers in Psychology, 2016, 7: 683.

13. Wei Zhu#, Mian Wang#, Yebo Fu, Nathan J Castro, Sidney W Fu, Lijie Grace Zhang*. Engineering a Biomimetic Three-Dimensional Nanostructured Bone Model for Breast Cancer Bone Metastasis Study. Acta Biomaterialia, 2015, 14, 164-174.

14. Mian Wang, Hilal Yazici, Arthur Gonzales, Michael Keidar, Thomas Webster*. Selectively ablating malignant melanoma cell with combined therapy of cold atmospheric plasma (cap) and polymersomes loaded with protoporphyrin IX (PPIX). FASEB Journal, 2015, 29, 876.15.

15. Mian Wang, Wenwen Liu, Thomas J Webster*. Reducing Infection and Increasing Biocompatibility, Trace Metals and Infectious Diseases, 2015, 257.

16. Mian Wang, Xiaoqian Cheng, Wei Zhu, Benjamin Holmes, Michael Keidar, Lijie Grace Zhang*. Design of biomimetic and bioactive cold plasma-modified nanostructured scaffolds for enhanced osteogenic differentiation of bone marrow-derived mesenchymal stem cells. Tissue Engineering Part A, 2014, 20 (5-6), 1060-1071.

17. Mian Wang, Benjamin Holmes, Xiaoqian Cheng, Wei Zhu, Michael Keidar, Lijie Grace Zhang*. Cold atmospheric plasma for selectively ablating metastatic breast cancer cells. PloS one, 2013, 8 (9), e73741.

18. Mian Wang, Sidney W Fu, Lijie Grace Zhang*. Design of a novel three-dimensional biomimetic nano bone model for breast cancer bone metastasis and therapeutics discovery. Cancer Research, 2013, 73 (8).

19. Mian Wang, Nathan J Castro, Jian Li, Michael Keidar, Lijie Grace Zhang*. Greater Osteoblast and Mesenchymal Stem Cell Adhesion and Proliferation on Titanium with Hydrothermally Treated Nanocrystalline Hydroxyapatite/Magnetically Treated Carbon Nanotubes. Journal of Nanoscience and Nanotechnology, 2012, 12 (10), 7692-7702.

20. Mian Wang, Garima Bhardwaj, Thomas J Webster*. Anti-bacterial Properties of PEKK for Orthopedic Applications. International Journal of Nanomedicine, 2017, 12: 6471-6476.

21. Mian Wang, Benjamin M Geilich, Michael Keidar, Thomas J Webster*. Killing Malignant Melanoma Cells with Protoporphyrin IX (PPIX) Loaded Polymersome Mediated Photodynamic Therapy (PDT) and Cold Atmospheric Plasma (CAP), International Journal of Nanomedicine, 2017, 12, 4117- 4127.

22. Mian Wang, Thomas J Webster*. Nano-biomaterials and their applications, Elsevier, 2019, 153-161.

23. Mian Wang, Jian Li, Michael Keidar, Lijie Grace Zhang*. Design a biologically inspired nanostructured coating for better osseointegration. MRS Proceedings, 2012, 1418.

共同作者文章：

24. Zeyu Luo, Guosheng Tang, Hossein Ravanbakhsh, Wanlu Li, Mian Wang, Xiao Kuang, Carlos Ezio Garciamendez Mijares, Liming Lian, Junlong Liao, Maobin Xie, Jie Guo, Zongke Zhou, Yu Shrike Zhang*. Vertical 3D Bioprint with Gradient Microchannels for Muscle Tissue Fabrication. Advanced Materials, 2022, 34 (12), 2108931

25. Hui L Ma, Wanlu Li, Mian Wang, Laudemir C Varanda, Janice R Perussi, Y Zhang, Emanuel Carrilho*. In vitro 3D malignant melanoma model for the evaluation of hypericin-loaded oil-in-water microemulsion in photodynamic therapy. Bio-Design and Manufacturing, 2022, 1-14.

26. Chenshuo Ma, Wanlu Li, Daiwei Li, Maomao Chen, Mian Wang, Laiming Jiang, Luis Santiago Mille, Carlos Ezio Garciamendez, Qifa Zhou, Yu Shrike Zhang*, Junjie Yao*. Photoacoustic imaging of 3D-printed vascular networks. Biofabrication, 2022, 14(2): 0225001.

27. Riccardo Levato, Khoon S Lim, Wanlu Li, Ane Urigoitia Asua, Laura Blanco Peña, Mian Wang, Marc Falandt, Paulina Nuñez Bernal, Debby Gawlitta, Yu Shrike Zhang, Tim BF Woodfield*, Jos Malda*. Materials Today Bio, 2021, 12, 100162.

28. Guosheng Tang, Long Chen, Liming Lian, Fanghua Li, Hossein Ravanbakhsh, Mian Wang, Yu Shrike Zhang*, Chaobo Huang*. Designable dual-power micromotors fabricated from a biocompatible gas-shearing strategy. Chemical Engineering Journal, 2021, 407, 127187.

29. Liming Lian, Cuiping Zhou, Guosheng Tang, Maobin Xie, Zixuan Wang, Zeyu Luo, Julia Japo, Di Wang, Jianhua Zhou, Mian Wang, Wanlu Li, Sushila Maharjan, Marina Ruelas, Jie Guo, Xunwei Wu, Yu Shrike Zhang*. Uniaxial and coaxial vertical embedded extrusion bioprinting. Advanced healthcare materials, 2021, 9(11), 2102411.

30. Hongbin Li, Feng Cheng, Wanlu Li, Xia Cao, Zixuan Wang, Mian Wang, Juan Antonio Robledo-Lara, Junlong Liao, Carolina Chávez-Madero, Shabir Hassan, Jingwei Xie, Grissel Trujillo-de Santiago, Mario Moisés Álvarez, Jinmei He, Yu Shrike Zhang*. Expanding sacrificially printed microfluidic channel-embedded paper devices for construction of volumetric tissue models in vitro. Biofabrication, 2020, 12 (4), 045027.

31. Yi Zhang, Pere Dosta, João Conde, Nuria Oliva, Mian Wang, Natalie Artzi*. Prolonged Local In Vivo Delivery of Stimuli‐Responsive Nanogels That Rapidly Release Doxorubicin in Triple‐Negative Breast Cancer Cells. Advanced healthcare materials, 2020, 9(4), 1901101. (封面文章)

32. Sandra M Navarro Gallón, Ece Alpaslan, Mian Wang, Phillip Larese-Casanova, Martha E Londoño, Lucía Atehortúa, Juan J Pavón, Thomas J Webster*. Characterization and study of the antibacterial mechanisms of silver nanoparticles prepared with microalgal exopolysaccharides. Materials Science and Engineering: C, 2019, 99, 685-695.

33. Di Shi, Gujie Mi, Mian Wang, Thomas J Webster*. In vitro and ex vivo systems at the forefront of infection modeling and drug discovery. Biomaterials, 2019, 198, 228-249.

34. Robin Augustine, Alap Ali Zahid, Anwarul Hasan, Mian Wang, Thomas J Webster*. CTGF loaded electrospun dual porous core-shell membrane for diabetic wound healing. International journal of nanomedicine, 2019, 14, 8573.

35. Gujie Mi, Di Shi, Mian Wang, Thomas J Webster*. Reducing bacterial infections and biofilm formation using nanoparticles and nanostructured antibacterial surfaces. Advanced Healthcare Materials, 2018, 7(13), 1800103.

36. Junyan Zhang, Mian Wang, Thomas J Webster*. Silver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections. International journal of nanomedicine, 2018, 13, 6575.

37. Junyan Zhang, Mian Wang, Thomas J Webster*. Growth process and anticancer properties of gold nanorods. Journal of Biomedical Materials Research Part A, 2017, 105(9), 2616-2621.

38. Run Chang, Keerthana Subramanian, Mian Wang, Thomas J Webster*. Enhanced antibacterial properties of self-assembling peptide amphiphiles functionalized with heparin-binding cardin-motifs. ACS applied materials & interfaces. 2017, 9 (27), 22350-22360.

39. Owen Im, Jian Li, Mian Wang, Lijie Grace Zhang*, Michael Keidar*. Biomimetic three-dimensional nanocrystalline hydroxyapatite and magnetically synthesized single-walled carbon nanotube chitosan nanocomposite for bone regeneration. International journal of nanomedicine, 2012, 7, 2087.