教授

张云芳

发布时间:2019-05-08  

姓名:张云芳


学位:博士

导师情况:博士生导师

研究领域:父系获得性遗传、RNA修饰及表观遗传学调控

E-mail: zhangyunfang@tongji.edu.cn

通讯地址:上海市杨浦区四平路1239号,同济大学生命科学与技术学院,邮编200092

 

研究方向:

1,  研究父系获得性性状代际/跨代遗传的分子基础及调控网络

2,  探究精子中表观遗传印记信息的形成及其在早期胚胎中的解码机制

3,  解析tsRNARNA修饰调控早期胚胎发育及疾病发生的作用及机制

4,  挖掘RNA修饰参与tRNA功能调控及tsRNA生物合成的机制

 

个人简介:

2011年毕业于延边大学,获学士学位。2014年毕业于安徽大学(与中科院动物研究所联合培养),获理学硕士学位。2018年毕业于中国科学院大学中国科学院动物研究所,获理学博士学位。期间获国家留学基金委资助在内华达大学里诺医学院Dr. Qi Chen实验室进行联合培养。2018年至2021年作为引进人才就职于中国人民解放军陆军军医大学第二附属医院从事专职科研工作。202111月加入同济大学生命科学与技术学院,受聘同济大学“青年百人计划”A岗教授。

主要从事表观遗传学修饰及父系获得性遗传调控机制研究,发现精子tsRNA及其RNA修饰可作为一类新型表观遗传信息载体介导父系获得性代谢紊乱性状的代际遗传2016Science。进一步阐明了Dnmt2作为关键基因通过调控RNA修饰参与了精子tsRNA介导的获得性遗传2018Nature Cell Biology,提出“精子RNA编码指纹”重编程子代健康的概念2019Nature Reviews Endocrinology。此外,还建立了适用于tsRNA等复杂非编码小RNA的建库分析方法-PANDORA-Seq2021Nature Cell Biology在前期发现tsRNA在血清2014, JMCB和精子中大量富集的基础上,进一步证明tsRNA在多种组织细胞中广泛富集,并发现tsRNArsRNA具有影响胚胎干细胞分化的功能2021, Nature Cell Biology。部分研究成果入选2016年“中国科学十大进展”及“中国生命科学领域十大进展”,获2019年“全国妇幼健康科学技术奖自然科学奖一等奖”。作为项目及课题负责人主持国家级科研项目3项,其中包括国家自然科学基金优青项目(2021-2024)、国家自然科学基金面上项目(2020-2024),国家重点研发计划“发育编程及其代谢调节”重点专项课题(2019-2024)。曾获得吴瑞奖、中科院院长特别奖、中国科学院大学BHPB Scholarship、中国科学院优秀博士毕业生、北京市普通高等学校优秀毕业生、入选中国科学院优秀博士学位论文等荣誉和奖励。

 

本课题组常年招聘博士后、研究生及科研助理,欢迎博士生、硕士生和本科生报考和实习。

 

已发表文章:*共同第一作者;#共同通讯作者)

1.Huanping Guo*, Lin Xia*, Wei Wang*, Wei Xu*, Xipeng Shen, Xiao Wu, Tong He, Xuelin Jiang, Yinying Xu, Pan Zhao, Dongmei Tan, Xi Zhang#, Yunfang Zhang#. Hypoxia induces alterations in tRNA modifications involved in translational control. BMC Biology. (2023) Feb 21;21(1):39. 

2.Lin Xia*, Huanping Guo*, Xiao Wu*, Yinying Xu*, Pan Zhao*, Bingbing Yan, Yunjing Zeng, Yundi He, Dan Chen, Robert Peter Gale, Yunfang Zhang #, Xi Zhang#. Human circulating small non-coding RNA signature as a non-invasive biomarker in clinical diagnosis of acute myeloid leukaemia. Theranostics. (2023) Feb 13;13(4):1289-1301.

3.Huanping Guo*, Xipeng Shen*, Hua Hu*, Peng Zhou, Tong He, Lin Xia, Dongmei Tan,Xi Zhang #, and Yunfang Zhang #. Alteration of RNA modification signature in human sperm correlates with sperm motility. Molecular Human Reproduction. (2022) Aug 12; 28(9):gaac031. 

4.Tong He*, Huanping Guo*, Lin Xia*, Xipeng Shen, Yun Huang, Xiao Wu, Xuelin Jiang, Yinying Xu, Yi Tan, Yunfang Zhang #, Dongmei Tan #. Alterations of RNA Modification in Mouse Germ Cell-2 Spermatids Under Hypoxic Stress. Frontiers in Molecular Biosciences. (2022) Jun 14; 9:871737. 

5.Bin Wang, Lin Xia, Dan Zhu, Hongtao Zeng, Bin Wei, Likui Lu, Weisheng Li, Yajun Shi, Jingliu Liu, Yunfang Zhang# & Mao Sun#. Paternal High-Fat Diet Altered Sperm 5‘tsRNA-Gly-GCC Is Associated with Enhanced Gluconeogenesis in the Offspring. Frontiers in Molecular Biosciences. (2022) Apr 11;9:857875.

6.Junchao Shi*Yunfang Zhang*, Dongmei Tan*, Xudong Zhang*, Menghong Yan*, Ying Zhang*, Marta Shahbazi, Kirsty Mackinlay, Reuben Franklin,  Shichao Liu, Bemhard Kuhle, Emma R, James, Liwen Zhang, Yongcun Qu, Qiwei Zhai, Wenxin Zhao, Linlin Zhao, Changcheng Zhou, Weifeng Gu, Jernej Murn, Jingtao Guo, Douglas T. Carrell, Yingsheng Wang, Xuemei Chen, Bradley R. Cairms, Xianglei Yang, Paul Schimmel, Magdalena Zemicka-Goetz, Sihem Cheloufi#, Ying Zhang#, Tong Zhou#, Qi Chen#. PANDORA-Seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications. Nature Cell Biology (2021) Apr 05; 23(4), 424-436. 

7.Tong He*, Huanping Guo*, Xipeng Shen*, Xiao Wu, Lin Xia, Xuelin Jiang, Yinying Xu, Dan Chen, Yunfang Zhang#, Dongmei Tan#, Yi Tan#. Hypoxia-induced alteration of RNA modifications in the mouse testis and sperm. Biology of Reproduction. 2021 Nov 15;105(5):1171-1178. 

8.Yunfang Zhang*, Junchao Shi*, Minoo Rassoulzadegan, Francesca Tuorto and Qi Chen#. Sperm RNA code programmes the metabolic health of offspring. Nature Reviews Endocrinology. (2019) Jun 24; (15):489–498.

9.Jun Chao Shi*, Yunfang Zhang*, Tong Zhou#, Qi Chen#. tsRNAs: The Swiss Army Knife for Translational Regulation. Trends in Biochemical Sciences. (2019) Mar;44(3):185-189.

10.Yunfang Zhang*, Xudong Zhang*, Junchao Shi*, Francesca Tuorto*, Xin Li*, Yusheng Liu, Reinhard Liebers, Tong Zhou, Wei Yan, Frank Lyko, Ying Zhang#, Qi Zhou#, Enkui Duan#, Qi Chen#. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nature Cell Biology. (2018) April 24(20),535-540. 

-Highlighted in Nature Reviews Endocrinology;

11.Yunfang Zhang*, Junchao Shi, Qi Chen#. tsRNAs: new players in mammalian retrotransposon control. Cell Research(2017) Nov;27(11):1307-1308.

12.Qi Chen*, Menghong Yan*, Zhonghong Cao*, Xin Li*, Yunfang Zhang*, Junchao Shi*, Gui-hai Feng, Hongying Peng, Xudong Zhang, Ying Zhang, Jingjing Qian, Enkui Duan#, Qiwei Zhai# and Qi Zhou#. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science. (2016) Jan 22;351(6271):397-400.  

-News story by Science  

-Highlighted in Nat Rev Genet, Cell Metab, Cell Res, FASEB J, Bio Reprod, and Science Bulletin.  

13.Junchao Shi*, Yunfang Zhang* and Qi Chen#. Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence. Environmental Epigenetics. (2016) 2 (2): dvw014; 

14.Yunfang Zhang*, Ying Zhang*, Junchao Shi*, He Zhang, Zhonghong Cao, Xuan Gao, Wanhua Ren, Yunna Ning, Lina Ning, Yujing Cao, Yongchang Chen, Weizhi Ji, Zi-jiang Chen#, Qi Chen#, and Enkui Duan#. Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection.Journal of Molecular Cell Biology. (2014) 6:172-174.

-Cover Story    -Editor’s Recommendation

15.张云芳; 张莹; 陈琦#; 段恩奎#; 精子RNA 及RNA 修饰在获得性遗传中的研究进展。《生命科学》 (2018), 30(11): 1202-1209.

16.杨程*;夏琳*;赫童;苟阳;唐永杰;彭贤贵;张曦#;张云芳#。表观遗传学修饰在血液肿瘤中的研究进展。《生物化学与生物物理进展》.(2020) 年第 05 期。

17.作为副主编撰写了《医话血液》科普书籍,重庆大学出版社,2020年10月1日。 

18.Xiaohua Lei#*; Yujing Cao*; Baohua Ma*; Yunfang Zhang; Lina Ning; Jingjing Qian; Liwen Zhang; Yongcun Qu; Tao Zhang; Dehong Li; Qi Chen; Junchao Shi; Xudong Zhang; Chiyuan Ma; Ying Zhang#; Enkui Duan#; Development of mouse preimplantation embryos in space. National Science Reviews. 2020, nsr(nwaa062)

19.Jingjing Qian; Yunfang Zhang; Yongcun Qu; Liwen Zhang; Junchao Shi; Xudong Zhang; Shichao Liu; Kim BH; Hwang SJ; Tong Zhou; Qi Chen; Ward SM; Enkui Duan#; Ying Zhang#; Caffeine consumption during early pregnancy impairs oviductal embryo transport, embryonic development and uterine receptivity in mice., Biology of Reproduction, (2018), 99(6): 1266-1275.

20.Lina Ning*, Xiaohua Lei*, Yujing Cao, Yunfang Zhang, Zhonghong Cao, Qi Chen, Enkui Duan#. Effect of Short-Term Hypergravity Treatment on Mouse 2-Cell Embryo Development. Microgravity Sci. Technol. (2015) 27:465–471;

21.He Zhang*, Ying Zhang*, Huashan Zhao, Yunfang Zhang, Qi Chen, Hongying Peng, Li Lei Jingqiao Qiao, Junchao Shi, Zhonghong Cao, Enkui Duan#, Yaping Jin#. Hormonal regulation of ovarian bursa fluid in mice and involvement of aquaporins. PLOS ONE. (2013) May 22;8(5):e63823. 

Copyright© 2011-2015 生命科学与技术学院, All rights reserved

地址:上海市四平路1239号 电话:021-65981041 传真:65981041