姓         名：薛 雷

学         位：博士

导师情况：博士生导师

研究领域：分子遗传学

     E-mail：lei.xue@mail.tongji.edu.cn

通讯地址： 上海市四平路1239号，同济大学生命科学与技术学院（200092）

个人简介：

      北京大学生物系学士，中国科学院上海细胞生物学研究所硕士，瑞士苏黎世大学分子生物学研究所博士，美国耶鲁大学医学院博士后。 历任耶鲁大学医学院副研究员 (Associate Research Scientist)，霍华德修斯医学研究院 (Howard Hughes Medical Institute) 研究专家 (Research Specialist)，自2008年9月起任同济大学生命科学与技术学院教授，博导，首席科学家。

研究领域：

    JNK信号通道在细胞增殖、迁移、凋亡、应激反应和个体衰老中起着至关重要的作用，其失调可导致发育缺陷和过早衰老，并和肿瘤发生和迁移、免疫失调、阿尔兹海默症及多种重要疾病的发生与发展密切相关。

    近年来，我们以果蝇为模式动物进行遗传筛选，找到了JNK信号通道上30多个新的基因，目前已分析鉴定其中部分基因，成果发表在Developmental Cell和Science 等国际顶级学术杂志。我们将继续研究其余的基因，探索它们在JNK信号通道中的分子功能，阐明其在细胞凋亡、个体衰老、癌症及阿尔兹海默症中的作用机制。

    选择是一种行为，也代表着智慧，其调控分子和作用机制仍有待破解。我们利用果蝇的择偶方式和取向，研究选择的分子机制以及调控选择的遗传因素。

    我们还建立了癌症和阿尔兹海默症的果蝇模型，并利用这些疾病模型筛选和检验各类中药成分对延缓衰老、治疗癌症和老年痴呆症等疾病的效果。

代表性论文：

• X Wang, Z Wang, Y Chen, X Huang, Y Hu, R Zhang, M S Ho and L Xue* (2014）FoxO Mediates APP-Induced AICD-Dependent Cell Death. Cell Death Dis. 5, e1233; doi:10.1038/cddis.2014.196.

• Y Hu, Y Han, X Wang and L Xue* (2014) Aging-related Neurodegeneration Eliminates Male Courtship Choice in Drosophila. Neurobiology of Aging 35，2174-2178.

• X Ma, W Li, H Yu, Y Yang, M Li, L Xue* and T Xu* (2014) Bendless modulates JNK-mediated cell death and migration in Drosophila. Cell Death Diff. 21, 407-415.

• Y Wang and L Xue* (2014) Mapping It out: A Novel Signaling Pathway Linking Aβ-PrPc-Fyn Complex to Cognitive Impairment in Alzheimer’s Disease. Adv. Alz. Dis. 3, 20-23.

• X Ma, Y Shao, H Zheng, M Li, W. Li and L. Xue* (2013) Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila. Cell Death Dis. e864.

• H. Yang, W. Li, H. Yu, R. Yuan, Y. Yang, K. Pung, P. Li and L. Xue* (2013) Physiological Effects of L-Theanine on Drosophila melanogaster. Molecules 18,13175-13187

• X. Ma, L. Yang, Y. Yang, M. Li, W. Li* and L. Xue* (2013) dUev1a Modulates TNF-JNK Mediated Tumor Progression and Cell Death in Drosophila. Dev. Biol. 380, 211-221.

• L. Pung, X. Wang, M. Li, L. Xue* (2013) The role of APP in Alzheimer’s disease. Adv. Alz. Dis. 2, 60-65

• X. Ma, J. Huang, Y. Yang, W. Li and L. Xue* (2012) NOPO Modulates Egr- induced JNK- independent cell death in Drosophila. Cell Res. 22,425-431.

• W. Li, S. Li, S. Zhang and L. Xue* (2012) A Broad Expression Profile of the GMR-GAL4 driver in Drosophila melanogaster. Genet. Mol. Res.11,1997-2002.

• H. Huang, G. Du, H. Chen, X. Liang, C. Li, N. Zhu, L. Xue, J. Ma and R. Jiao (2011) Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus. Development 138, 2477-2485.

• J. Liu*, M. Ghanim*, L. Xue* et al., (2009) Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer. Science 323:1218-1222. (* Equal contribution)

• L. Xue, T. Igaki, E. Kuranaga, H. Kanda, M. Miura and T. Xu (2007) Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Dev. Cell 13:446-454.

• L. Xue and M. Noll. (2002) Dual role of the Pax gene paired in accessory gland development of Drosophila. Development 129:339-46.

• L. Xue, X. Li and M. Noll. (2001) Multiple protein functions of paired in Drosophila development and their conservation in the Gooseberry and Pax3 homologs. Development 128:395-405.

• L. Xue and M. Noll. (2000) Drosophila female sexual behavior induced by sterile males showing copulation complementation. Proc. Natl. Acad. Sci. USA 97: 3272-3275.

• L. Xue and M. Noll. (1996) The functional conservation of proteins in evolutionary alleles and the dominant role of enhancers in evolution. EMBO. J., 15: 3722-3731.