张小白

发布时间：2019-05-08

姓名：张小白

学位：博士

研究领域：生物信息学，表观遗传组学

E-mail：zhangxb@tongji.edu.cn

联系电话：021-65981193

通讯地址： 上海市杨浦区四平路1239号，同济大学生命科学与技术学院

个人简介:

张小白，博士，现任同济大学生命科学与技术学院助理教授，硕士生导师。2004年本科毕业于南京航空航天大学，2008-2009年美国佐治亚大学系统生物学博士联合培养，2011年博士毕业于南京航空航天大学。2011年进入同济大学转化医学高等研究院任助理研究员，2012年同济大学生物医学工程博士后，2015年任同济大学生命科学与技术学院助理教授。工作期间主持国家自然科学基金青年项目一项、中国博士后科学基金及上海市博士后科研基金各一项，作为科研骨干参与科技部863重大项目一项，参与科技部973重大项目一项。

研究方向：

发展和应用生物信息学方法，整合转录组及表观遗传组学数据，研究体细胞重编程、干细胞分化、胚胎发育等过程中的分子机理以及表观遗传调控机制。

发表论文（#第一作者，*通讯作者）：

1.Ye Y, Li M, Gu L, Chen X, Shi J, Zhang X*, Jiang C*. Chromatin remodeling during in vivo neural stem cells differentiating to neurons in early Drosophila embryos. Cell Death Differ 2017, 24(3): 409-420..

2.Shang W, Shen Y, Gao S, Feng G, Feng Y, Wang Z*, Zhang X*. Comparison of HLA-A, -B and -DRB1 Loci Polymorphism between Kidney Transplants of Uremia Patients and Healthy Individuals in Central China. PLoS One 2016, 11(10):e0165426.

3.Ye Y, Gu L, Chen X, Shi J, Zhang X*, Jiang C*. Chromatin remodeling during the in vivo glial differentiation in early Drosophila embryos. Sci Rep 2016, 6:33422.

4.Chen J, Chen X, Li M, Liu X, Gao Y, Kou X, Zhao Y, Zheng W, Zhang X, Huo Y, Chen C, Wu Y, Wang H, Jiang C, Gao S. Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming. Cell Rep 2016, 14(6):1540-1554.

5.Yang Y#, Zhang X#, Yi L, Hou Z, Chen J, Kou X, Zhao Y, Wang H, Sun XF, Jiang C, wang Y, Gao S. Naive Induced Pluripotent Stem Cells Generated From beta-Thalassemia Fibroblasts Allow Efficient Gene Correction With CRISPR/Cas9. Stem Cells Transl Med 2015.

6.Huang K#, Zhang X#, Shi J#, Yao M, Lin J, Li J, Liu H, Li H, Shi G, Wang Z, Zhang B, Chen J, Pan G, Jiang C, Pei D, Yao H. Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells. Sci Rep 2015, 5:17691.

7.Tao Y, Zheng W, Jiang Y, Ding G, Hou X, Tang Y, Li Y, Gao S, Chang G, Zhang X, Liu W, Kou X, Wang H, Jiang C, Gao S. Nucleosome organizations in induced pluripotent stem cells reprogrammed from somatic cells belonging to three different germ layers. BMC Biol 2014, 12(1):109.

8.Shen J, Jia W, Yu Y, Chen J, Cao X, Du Y, Zhang X, Zhu S, Chen W, Xi J, Wei T, Wang G, Yuan D, Duan T, Jiang C, Kang J. Pwp1 Is Required for the Differentiation Potential of Mouse Embryonic Stem Cells through Regulating Stat3 Signaling. Stem Cells 2014.

9.Shi J, Zheng M, Ye Y, Li M, Chen X, Hu X, Sun J, Zhang X*, Jiang C*. Drosophila Brahma complex remodels nucleosome organizations in multiple aspects. Nucleic Acids Res 2014, 42(15):9730-9739.

10.Yin R, Gu L, Li M, Jiang C*, Cao T*, Zhang X*. Gene expression profiling analysis of bisphenol A-induced perturbation in biological processes in ER-negative HEK293 cells. PLoS One 2014, 9(6):e98635.

11.Lin J, Chen G, Gu L, Shen Y, Zheng M, Zheng W, Hu X, Zhang X, Qiu Y, Liu X, Jiang C. Phylogenetic affinity of tree shrews to Glires is attributed to fast evolution rate. Mol Phylogenet Evol 2014, 71:193-200.

12.Li M, Liu Z, Gu L, Yin R, Li H, Zhang X, Cao T, Jiang C. Toxic effects of decabromodiphenyl ether (BDE-209) on human embryonic kidney cells. Front Genet 2014, 5:118.

13.Zhang X#, Shen Y#, Ding G, Tian Y, Liu Z, Li B, Wang Y, Jiang C: TFPP: an SVM-based tool for recognizing flagellar proteins in Trypanosoma brucei. PLoS One 2013, 8(1):e54032.

14.Song X, Cheng L, Zhou T, Guo X, Zhang X, Chen YP, Han P, Sha J. Predicting miRNA-mediated gene silencing mode based on miRNA-target duplex features. Comput Biol Med 2012, 42(1):1-7.

15.Song X, Zhou T, Jia H, Guo X, Zhang X, Han P, Sha J. SProtP: a web server to recognize those short-lived proteins based on sequence-derived features in human cells. PLoS One 2011, 6(11):e27836.

16.Zhang X, Cui J, Nilsson D, Gunasekera K, Chanfon A, Song X, Wang H, Xu Y, Ochsenreiter T. The Trypanosoma brucei MitoCarta and its regulation and splicing pattern during development. Nucleic Acids Res 2010, 38(21):7378-7387.

17.Zhang X, Song X, Wang H. Characteristic comparison between two types of miRNA precursors in metazoan species. Biosystems 2010, 100(2):144-149.

18.Zhang H, Song X, Wang H, Zhang X. MIClique: An algorithm to identify differentially coexpressed disease gene subset from microarray data. J Biomed Biotechnol 2009, 2009:642524.

19.Zhang X, Song X, Wang H, Zhang H: Sequential local least squares imputation estimating missing value of microarray data. Comput Biol Med 2008, 38(10):1112-1120.

地址：上海市四平路1239号电话：021-65981041 传真：65981041