个人简介：

2004年毕业于吉林大学，获得生物技术专业学士学位；2009年毕业于中国科学院上海生命科学学院生化与细胞研究所 ，获得细胞生物学专业博士学位，主要从事神经系统内膜表面离子通道及阿片受体行使功能机制的研究；2009年-2016年于加州大学圣地亚哥分校从事博士后研究，主要研究方向为诱导多能干细胞的免疫原性、干细胞的干性维持机制、神经疾病的干细胞模型。 

神经和代谢性疾病密切相关并严重危害人类健康。以基因编辑、干细胞及类器官等新手段，揭示神经代谢性疾病的发病 机制，为疾病的治疗提供新方法。以通讯作者或第一作者（含共同）发表论文15篇（Cell Stem Cell、Neuron、Molecular Psychiatry、Science Advances、Cell  Death & Differentiation、PNAS等）；主持国自然面上项目3项，国家重点研发计划骨干1项，并获上海市青年科技启明星人才计划。

主要学术成就：利用基因编辑技术阐明神经代谢疾病Wolfram综合征致病基因WFS1在神经突触形成和功能中的作用，发现Riluzole可作为潜在药物有效治疗神经功能损伤；破译体内胰岛β细胞再生的高分辨率转录组路径图，实现再生胰岛β细胞的新途径，为糖尿病等代谢疾病治疗提供新思路；开发基因编辑工具miniCAFE激活内源基因表达，在神经代谢疾病治疗中具有广泛的应用前景；阐明cAMP信号通路多个关键信号分子维持代谢稳态的机制，为代谢疾病治疗提供多个新靶点。

代表性文章（通讯或第一作者论文）：

1. Hu R*, Chen X*, Su Q*, Wang Z, Wang X, Gong M, Xu M, Le R, Gao Y, Dai P, Zhang ZN^#, Shao L^#, Li W^#. ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models. Cell Death Differ. 2024 Feb 6.

2. Liu G*, Li Y*, Li M*, Li S, He Q, Liu S, Su Q, Chen X, Xu M, Zhang ZN^#, Shao Z^#, Li W^#. Charting a high-resolution roadmap for regeneration of pancreatic β cells by in vivo transdifferentiation from adult acinar cells. Sci Adv.1.2023 May 24;9(21): eadg2183. 

3. Yuan F*, Li Y*, Hu R*, Gong M, Chai M, Ma X, Cha J, Guo P, Yang K, Li M, Xu M, Ma Q, Su Q, Zhang C, Sheng Z, Wu H, Wang Y, Yuan W, Bian S, Shao L, Zhang R, Li K, Shao Z^#, Zhang ZN^#, Li W^#. Modeling disrupted synapse formation in wolfram syndrome using hESCs-derived neural cells and cerebral organoids identifies Riluzole as a therapeutic molecule. Mol Psychiatry.2023 Apr;28(4):1557-1570.

4. Zhang X*, Lv S*, Luo Z*, Hu Y, Peng X, Lv J, Zhao S, Feng J, Huang G, Wan QL, Liu J, Huang H, Luan B, Wang D, Zhao X, Lin Y, Zhou Q^#, Zhang ZN^#, Rong Z^#. MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo. Nucleic Acids Res. 2021 Apr 19;49(7):4171-4185.

5. Li J, Lv S, Qiu X, Yu J, Jiang J, Jin Y, Guo W, Zhao R, Zhang ZN^#, Zhang C^#, Luan B^#. BMAL1 functions as a cAMP-responsive coactivator of HDAC5 to regulate hepatic gluconeogenesis. Protein Cell. 2018 Nov;9(11):976-980.

6. Qiu X, Li J, Lv S, Yu J, Jiang J, Yao J, Xiao Y, Xu B, He H, Guo F, Zhang ZN^#, Zhang C^#, Luan B^#. HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation. J Lipid Res. 2018 Feb;59(2):330-338.

7. Lv S, Qiu X, Li J, Liang J, Li W, Zhang C, Zhang ZN^#, Luan B^#. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. J Endocrinol. 2017 Aug;234(2):73-87.

8. Lv S, Li J, Qiu X, Li W, Zhang C, Zhang ZN^#, Luan B^#. A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses. Cell Death Differ. 2017 Mar;24(3):492-499.

9. Zhang ZN*, Gong L*, Lv S*, Li J, Tai X, Cao W, Peng B, Qu S, Li W^#, Zhang C^#, Luan B^#. SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300. Sci Rep. 2016 Mar 17;6:23317. 

10. Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR^#, Almutairi A^#. Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction. Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3185-90.

11. Lv S, Qiu X, Li J, Li W, Zhang C, Zhang ZN^#, Luan B^#. Suppression of CRTC2-mediated hepatic gluconeogenesis by TRAF6 contributes to hypoglycemia in septic shock. Cell Discov. 2016 Dec 13;2:16046.

12. Zhao T*, Zhang ZN*, Westenskow PD*, Todorova D, Hu Z, Lin T, Rong Z, Kim J, He J, Wang M, Clegg DO, Yang YG, Zhang K, Friedlander M, Xu Y. Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells. Cell Stem Cell. 2015 Sep 3;17(3):353-9.

13. Zhang ZN*, Chung SK*, Xu Z, Xu Y. Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation. Stem Cells. 2014 Jan;32(1):157-65.

14. He SQ*, Zhang ZN*, Guan JS*, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Lu YJ, Bao L^#, Zhang X^#. Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron. 2011 Jan 13;69(1):120-31.

15. Zhang ZN*, Li Q*, Liu C, Wang HB, Wang Q, Bao L. The voltage-gated Na⁺ channel Na_v1.8 contains an ER-retention/retrieval signal antagonized by the β3 subunit. J Cell Sci. 2008 Oct 1;121(Pt 19):3243-52.