研究方向：新型纳米载药粒子在肿瘤局部和靶向治疗中的应用及机制研究

E-mail：mqchu98@tongji.edu.cn

联系电话：13671838898

通讯地址：上海市四平路1239号，同济大学生命科学与技术学院（200092）

个人简介：

       储茂泉，教授，博士生导师。主要从事纳米生物医学教学与科研。2007年入选教育部新世纪优秀人才支持计划，2010年入选同济大学攀登高层次优秀人才支持计划，2012年获持续支持，2013年获我心目中的同济大学好导师之博学多思奖。近年来的研究成果主要发表在Small, Biomaterials, Theranostics, Nanotoxicology, Nanoscale, Carbon 等国际刊物上，出版了纳米生物医学领域英文专著3部、参编1部（均为新加坡世界科学出版社出版）。担任多个人才项目评审专家，担任国际Gandhian Young Technological Innovation Awards评审专家，担任Biomolecules客座编辑，是Advanced Materials、ACS Nano等20余个国际高影响因子期刊审稿人，担任International Journal of Nanomaterials, Nanotechnology and Nanomedicine等国际期刊编委。

开设教学课程：纳米生物学

主要开展的研究：     

 本课题组目前在纳米载药粒子合成、组装及肿瘤治疗方面开展了很多工作。我们设计合成的纳米复合粒子及纳米载药粒子能通过光热效应、光动力效应、化学动力学效应、机械力等效应杀伤肿瘤细胞，抑制小鼠肿瘤生长，在肿瘤局部治疗方面有重要作用；我们根据肿瘤特殊微环境设计的纳米载药粒子，能减少被体内免疫系统清除，能将化疗和光动力治疗等药物有效输送至肿瘤部位，并与免疫治疗相结合，在近红外激光、动态磁场等诱导下，能发挥纳米载药粒子协同靶向抑制肿瘤生长与转移；我们还深入研究生物发光共振能力转移诱导下纳米载药粒子的光动力治疗和载药细菌在肿瘤靶向治疗中的作用；从分子和细胞水平上研究抑制肿瘤生长与转移的机理。

纳米生物医学是多学科交叉融合的前沿领域，欢迎来自生物、医学、药学、食品及材料化学等背景的青年学生加入本课题组。

本课题组学生获得的部分荣誉：

       近年来，本课题组有2名研究生获得国家奖学金（教育部颁发），1名研究生获得安发国际奖学金，2名研究生分别获得同济大学优秀博士生奖学金，1名获得优秀硕士生奖学金，1名研究生获得上海市优秀毕业生称号，多名学生获得同济大学优秀毕业生称号，多名学生获得同济大学研究生社会活动奖学金，多名学生获得同济大学优秀学生干部及标兵称号等多种荣誉。

出版专著

1. Maoquan Chu (author).《Semiconductor Quantum Dots and Rods for in Vivo Imaging and Cancer Phototherapy》. World scientific publishing, Singapore, Aug 2017.

2. Maoquan Chu (editor).《Advanced Nanomaterials for Bioimaging and Cancer Therapy》, World scientific publishing, Singapore, Sep 2017.

3. Maoquan Chu (editor). 《Synthesis and Biomedical Applications of Graphene Quantum Dots》, World scientific publishing, Singapore, Sep 2017.

以下为参编

1. Maoquan Chu. Chapter 4: Magnetic Fe₃O₄ Nanoparticles for Cancer Photothermal Therapy. pp: 67-89.《Bio-Inspired Nanomaterials and Applications-Nano Detection, Drug/Gene Delivery, Medical Diagnosis and Therapy》. World Scientific Publishing. Singapore. Jan 2015.

近年来发表的主要论文

1. Yuliang Guo, Yang Chen, Pomchol Han, Yuxiong Liu, Wenhao Li, Fangliang Zhu, Kai Fu, Maoquan Chu*. Biocompatible chitosan-carbon nanocage hybrids for sustained drug release and highly efficient laser and microwave co-irradiation induced cancer therapy. Acta Biomaterialia. 2020, 103: 237-246

2. Xin Gui, Yang Chen, Zheyu Zhang, Longfei Lei, Fangliang Zhu, Wenxuan Yang, Yuliang Guo, Maoquan Chu*. Fluorescent hollow mesoporous carbon spheres for drug loading and tumor treatmentthrough 980-nm laser and microwave co-irradiation. Biomaterials 2020, 248: 120009

3. Ding Zhang,Zefei Zhang, Ying Wu, Kai Fu, Yang Chen, Wenhao Li, Maoquan Chu*.Systematic Evaluation of Graphene Quantum Dot Toxicity to Male Mouse Sexual Behaviors, Reproductive and Offspring Health. Biomaterials. 2019, 194: 215-232

4. Yang Chen, Yuliang Guo, Pomchol Han, Dan Li, Xin Gui, Zefei Zhang, Kai Fu, Maoquan Chu*. Graphitic carbon nanocages as new photothermal agent and drug carrier for 980-nm-laser-driven cancer therapy. Carbon, 2018, 136: 234-247.

5. Wenhao Li, Pomchol Han, Yang Chen, Yuliang Guo, Dan Li, Ying Wu, Yan Yue, Maoquan Chu*. Drug-Loaded Polymer-Coated Graphitic Carbon Nanocages for Highly Efficient in Vivo Near-Infrared Laser-Induced Synergistic Therapy through Enhancing Initial Temperature. ACS Appl. Mater. Interfaces 2018, 10(37):31186-31197.

6. Yang Chen, Pomchol Han,Ying Wu, Zefei Zhang, Yan Yue, Wenhao Li, Maoquan Chu*.Hedgehog-like Gold-coated Magnetic Microspheres that Strongly Inhibit Tumor GrowththroughMagnetomechanical Force and Photothermal Effects. Small, 2018, 1802799.

7. Qiang Wu, Maoquan Chu*, Yuxiang Shao, Fangjie Wo, Donglu Shi. Reduced graphene oxideconjugated with CuInS2/ZnS nanocrystals with low toxicity for enhanced photothermal and photodynamic cancer therapies. Carbon 108 (2016) 21-37

8. Fangjie Wo, Rujiao Xu, Yuxiang Shao, Zheyu Zhang, Maoquan Chu*, Donglu Shi, Shupeng Liu. A multimodal system with synergistic effects of magneto-mechanical, photothermal, photodynamic and chemo therapies of cancer in graphene-quantum dot-coated hollow magnetic nanospheres. Theranostics, 2016, 6(4):485-500.

9. Maoquan Chu *,Wangxi Hai, Zheyu Zhang, Fangjie Wo, Qiang Wu, Zefei Zhang, Yuxiang Shao, Ding Zhang, Donglu Shi.Melanin nanoparticlesderived from a homology of medicine and foodfor sentinel lymph node mapping and highly efficient photothermal in vivo cancer therapy.Biomaterials 91 (2016) 182-199.

10. Ding Zhang, Zheyu Zhang, Yayun Liu, Maoquan Chu*, Chengyu Yang, Wenhao Li, Yuxiang Shao, Yan Yue, Rujiao Xu. The short- and long-term effects of orally administered high-dose reduced graphene oxide nanosheets on mouse behaviors. Biomaterials. 2015, 68:100-113.

11. Shun Xu, Zheyu Zhang & Maoquan Chu*. Long-term toxicity of reduced graphene oxide nanosheets: effects on female mouse reproductive ability and offspring development. Biomaterials. 2015,54:188-200.

12. Maoquan Chu*, Haikuo Li, Qiang Wu, Fangjie Wo & Donglu Shi. Pluronic-encapsulated natural chlorophyll nanocomposites for in vivo cancer imaging and photothermal/photodynamic therapies.Biomaterials. 2014, 35: 8357-8373

13. Maoquan Chu*, Yuxiang Shao, JinliangPeng, Xiangyun Dai, Haikuo Li, Qingsheng Wu, Donglu Shi. Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles. Biomaterials. 2013,34:4078-4088

14. Maoquan Chu*, Jinliang Peng, Jiajia Zhao, Shanlu Liang, Yuxiang Shao, Qiang Wu. Laser light triggered-activated carbon nanosystem for cancer therapy. Biomaterials. 2013, 34(7),1820-1832.

15. Maoquan Chu*, Xiaojing Pan, Ding Zhang, Qiang Wu, Jinliang Peng, Wangxi Hai. The therapeutic efficacy of CdTe and CdSe quantum dots for photothermal cancer therapy. Biomaterials. 2012, 33(29): 7071-7083.

16. Lina Fan, Qiang Wu, Maoquan Chu*. Near-infrared fluorescent chlorophyll nanoscale liposomes for sentinel lymph node mapping. International Journal of Nanomedicine. 2012:7 3071–3080

17. Qiang Wu, Maoquan Chu*. Self-illuminating quantum dots for highly sensitive in vivo real-time luminescent mapping of sentinel lymph nodes. International Journal of Nanomedicine. 2012, 7: 3433–3443.

18. Wu Congyu, Yu Cong, ChuMaoquan *. A gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy. International Journal of Nanomedicine. 2011:6 807–813.

19. Maoquan Chu*, Qiang Wu, Hui Yang, Ruiqi Yuan, Shengke Hou, Yifeng Yang, Yajuan Zou, Shi Xu, Kaiyi Xu, Ailing Ji & Lingyi sheng.Transfer of quantum dots from pregnant mice to pups across the placental barrier. Small, 2010, 6: 670-678.

20. Maoquan Chu*, Fang Wu, Quan Zhang, Tiantian Liu, Yang Yu, Ailing Ji, Kaiyi Xu, Zhenhua Feng & Jian Zhu. A novel method for preparing quantum dot nanospheres with narrow size distribution. Nanoscale. 2010, 2: 542-547.