个人简介
高亚威博士2009年于上海交通大学,获得理学学士学位。2014年于北京协和医学院,北京生命科学研究所,获得理学博士学位。2014年2月起在同济大学工作至今。主要从事发育、转分化、核移植和诱导重编程等过程的表观调控机制研究。2013年与陈嘉瑜博士合作在cell stem cell上发表封面文章揭示了DNA甲基化与羟甲基化介导的表观遗传重编程的分子机制,该论文被评为年度十佳论文。通过建立和完善多种微量测序技术,开展了包括早期胚胎组蛋白修饰图谱的测定和核移植胚胎重编程机制等方面的研究,成果之一发表于Nature。近五年,以第一作者和通讯作者在Nature,Cell stem cell,Nature Cell Biology,Cell Reports等一流刊物上发表论文,入选国家第三批国家青年拔尖人才(2017年),上海市晨光计划,青年科学启明星计划,中国科协“青年人才托举工程”等人才项目。
近年代表文章:
1. Xiaoyu Liu*, Chenfei Wang*, Wenqiang Liu*, Jingyi Li*, Chong Li, Xiaochen Kou, Jiayu Chen, Yanhong Zhao, Haibo Gao, Hong Wang, Yong Zhang#, Yawei Gao# & Shaorong Gao#
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos
Nature 2016 Sep 14;537(7621):558-562. (IF: 38.138)
2. Gao Y*, Chen J*, Li K, Wu T, Huang B, Liu W, Kou X, Zhang Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T, and Gao S
Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming
Cell Stem Cell , 2013. 12(4): p. 453-69. (IF: 25.315)
3. Jiayu Chen*, Yawei Gao*, Hua Huang , Yonghua Jiang , Hui Li , Shuai Gao , Yu Tao , Hong Wang , Hailin Wang , Tao Cai , Shaorong Gao
The Combination of Tet1 with Oct4 Generates High-Quality Mouse Induced Pluripotent Stem Cells (iPSCs)
Stem Cells , 2015 Mar;33(3):686-98. doi: 10.1002/stem.1879. (IF:7.133)
4. Gao, Y. and S. Gao, Quality Control: H2A.X Links to Better iPSCs.
Cell Stem Cell, 2014. 15(3): p. 259-60. (IF: 22.151)
5. Yonghua Jiang, Zhaohui Kou, Tong Wu, Weidong An, Ran Zhou, Hong Wang, Yawei Gao* and Shaorong Gao*
Xist Deficiency and Disorders of X-Inactivation in Rabbit Embryonic Stem Cells Can Be Rescued by Transcription-Factor-Mediated Conversion
Stem Cells and Development. October 1, 2014, 23(19): 2283-2296. doi:10.1089/scd.2014.0011 (IF: 4.15)
6. Wenqiang Liu*, Xiaoyu Liu*, Chenfei Wang*, Yawei Gao*#, Rui Gao, Xiaochen Kou,Yanhong Zhao, Jingyi Li, You Wu, Wenchao Xiu, Su Wang, Jiqing Yin, Wei Liu, Tao Cai,Hong Wang, Yong Zhang#, Shaorong Gao#
Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing Cell Discovery (2016) 2, 16010