姓名：郭旭东
学位：博士
导师情况：博士生导师
研究领域：干细胞与表观遗传学
研究方向：干细胞多能性形成、维持和心肌分化等细胞命运决定中的表观遗传机制研究

E-mail：19504@tongji.edu.cn

联系电话：021-65988560
通讯地址：上海市四平路1239号，同济大学生命科学与技术学院（200092）

个人简介：
      2010年毕业于同济大学生命科学与技术学院生物技术专业，获学士学位。2016年博士毕业于同济大学生命科学与技术学院生物化学与分子生物学专业。2016-2019年在同济大学生物医学工程和同济大学附属东方医院再生医学研究所从事博士后研究。自2019年2月起，受聘于同济大学转化医学高等研究院任特聘研究员。
      主要从事细胞命运决定中的表观遗传调控机制研究，以非编码RNA、表观调控分子在体细胞重编程和干细胞心肌分化等细胞命运改变过程中的表观遗传调控机制为主要方向。目前已发表SCI论文共30篇，并在Cell Stem Cell、Cell Res、Nat Commun、PNAS、Stem Cell Rep等杂志发表共同第一作者和共同通讯作者SCI论文共10篇。代表性研究成果2018年发表于Cell Stem Cell杂志，同期配发瑞典卡罗林斯卡学院著名心脏学专家Kenneth R. Chien教授撰写的专刊评述文章。作为项目负责人主持国家级科研项目3项，其中国家自然科学面上项目2项（在研）、青年基金1项（已结题）；主持上海市科委“青年科技启明星”计划（在研）。同时，作为项目骨干参与多项科技部国家重点研发计划、教育部创新团队项目、基金委重点、面上项目等。

代表性工作：

[1] Guo Xudong*,Xu Yanxin*, Wang Zikang, Wu Yukang, Chen Jiayu, Wang Guiying, Lu Chenqi, Jia Wenwen, Xi Jiajie, Zhu Songcheng, Jiapaer Zeyidan, Wan Xiaoping, Liu Zhongmin, Gao Shaorong, Kang Jiuhong#. A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis. Cell Stem Cell. 2018, 22(6):893-908.
[2] Guo Xudong*, Liu Qidong*, Wang Guiying, Zhu Songchen, Gao Longfei, Hong Wujun, Chen Yafang, Wu Minjuan, Liu Houqi, Jiang Cizhong, Kang Jiuhong#. microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming. Cell Research, 2013, 23:142-156.
[3] Chen Jiajing*, Wang Zikang*, Guo Xudong*, Li Fudong, Wei Qingtao, Chen Xuwen, Gong Deshun, Xu Yanxin, Chen Wen, Liu Yongrui, Kang Jiuhong#, Shi Yunyu#. TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells. Nature Communications. 2019. 10(1): 4273.
[4] Wang Guiying*, Guo Xudong*, Hong Wujun, Liu Qidong, Wei Tingyi, Lu Chenqi, Gao Longfei, Ye Dan, Zhou Yi, Chen Ji, Wang Jianmin, Wu Minjuan, Liu Houqi, Kang Jiuhong#. Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation. Proc Natl Acad Sci USA, 2013, 110(8):2858-2863.
[5] Yao Lyu, Wenwen Jia, Yukang Wu, Xin Zhao, Yuchen Xia, Xudong Guo#, Jiuhong Kang#. Cpmer: a new conserved eEF1A2-binding partner that regulates Eomes translation and cardiomyocyte differentiation. Stem Cell Reports. 2022. 17: 1-16. (#共同通讯)
[6] Jiabao Feng; Fugui Zhu; Dan Ye; Qingquan Zhang; Xudong Guo#; Changsheng Du#; Jiuhong Kang#. Sin3a drives mesenchymal-to-epithelial transition through cooperating with Tet1 in somatic cell reprogramming. Stem Cell Research & Therapy. 2022. 13(1): 29. (#共同通讯)
[7] Jianguo Li*; Yaqi Chen*; Xuecong Guo; Xiaofei Bai; Xu Xu; Tong Han; Ailing Tan; Nana Liu; Yuchen Xia; Qiaoyi Sun; Xudong Guo#; Jie Chen#; Jiuhong Kang#. lncNBAT1/APOBEC3A is a mediator of HBX-induced chemoresistance in diffuse large B-cell lymphoma cells, Molecular Therapy-Nucleic Acids. 2022, 27: 1064-1077. (#共同通讯)
[8] Guo Xudong*, Wang Zikang*, Lu Chenqi, Hong Wujun, Wang Guiying, Xu Yanxin, Liu Zhongmin, Kang Jiuhong#. LincRNA-1614 coordinates Sox2/PRC2-mediated repression of developmental genes in pluripotency maintenance. Journal of Molecular Cell Biology. 2018, 10(2):118-129.
[9] Zhao Xinying*, Guo Xudong*, Xing Libo, Yue Wenqin, Yin Haisen, He Miaoxia, Wang Jianmin, Yang Jianmin, Chen Jie#. HBV infection potentiates resistance to Sphase arrest-inducing chemotherapeutics by inhibiting CHK2 pathway in diffuse large B-cell lymphoma. Cell Death & Disease. 2018, 9(2):61.
[10] Tong Han*, Yukang Wu*, Xiang Hu, Yaqi Chen, Wenwen Jia, Qizhi He, Yiding Bian, Mengfei Wang, Xudong Guo#, Jiuhong Kang#, Xiaoping Wan#. NORAD orchestrates endometrial cancer progression by sequestering FUBP1 nuclear localization to promote cell apoptosis. Cell Death & Disease. 2020, 11:473. (#共同通讯)