教授

李维达

发布时间:2019-05-08  

姓        名:李维达
学        位:博士
导师情况:博士生导师
研究领域:干细胞与再生生物学;转分化;糖尿病药物开发

Email:liweida@tongji.edu.cn
通讯地址:上海市杨浦区四平路1239号,同济大学生命科学与技术学院522室,邮编200092
 
研究方向

1.利用基因编辑和干细胞诱导分化技术获得抗糖尿病的胰岛β细胞

2.重编程因子介导胰腺外分泌细胞向β细胞转化的体内机制研究

3.糖尿病疾病模型及Wolfram综合征疾病模型的构建

4.糖尿病及其相关代谢性疾病的新型药物开发

个人简介

     李维达,教授,博士生导师。2003年毕业于南开大学,获得生物技术专业学士学位;2009年毕业于北京大学,获得细胞生物学专业博士学位,2006-2009年于北京生命科学研究所NIBS及北京大学联合培养,主要从事凋亡细胞清除机制的研究;2010-2015年于哈佛大学干细胞研究所从事博士后研究,主要研究方向为通过干细胞和转分化技术开发糖尿病治疗的细胞疗法。2015至今为同济大学生命科学与技术学院教授,同年双聘为上海市东方医院再生医学研究所教授。

2012-2015 获美国JDRF(青少年糖尿病基金)Fellowship Award2016年国家科技部干细胞及转化青年项目首席科学家。

课题组成员:

副教授2人,科研助理1人,博士研究生13人,硕士研究生5

主要科研项目:

1.  国家重点研发计划干细胞及转化研究专项,利用体内微环境实现糖尿病中胰岛细胞转分化再生的机制研究,2016-2021,主持(首席科学家)

2. 国家重点研发计划干细胞及转化研究专项,利用干细胞构建模拟早期胚胎发育和特定器官形成的系统,2020-2024,在研,骨干

3.  国家自然科学基金面上项目,基于人胚胎干细胞诱导分化技术研究SLC30A8对人类胰岛β细胞功能成熟过程的调控机制,2019-2023,在研,主持

4.  国家自然科学基金面上项目,利用重编程因子实现体内胰腺外分泌细胞向β细胞转分化的机制研究,2022-2025,在研,主持

5.  海外高层次引进人才计划,基于干细胞技术治疗糖尿病的细胞疗法,2016,主持

代表性论文:

1. Qing Ma*, Yi-Ni Xiao*, Sheng Li, Menghan Wang, Zhihao Yang, Tinghui Xiao, Minglu Xu, Tengjiao Zhang, Rui Hu, Zhen-Ning Zhang, Qing He, Qiang Su, Fei Yuan, Jiaxu Zhao, Zheng-jun Chen, Weiyang Shi, Qiaolin Deng#, Xin Cheng#, Weida Li#. ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress induced cell death in diabetes. Nature Communications. In revision.

2. Gang Liu*, Yana Li*, Tengjiao Zhang*, Mushan Li*, Sheng Li, Qing He, Shuxin Liu, Minglu Xu, Tinghui Xiao, Zhen Shao#, Weiyang Shi#, Weida Li#. Mouse Single Pancreatic β Cell Transcriptomics Reveal Sexual Dimorphism of Transcriptomes and Identify Sex-dependent Type 2 Diabetes Altered Genes. Genomics, Proteomics & Bioinformatics. 2021. (online)

3. Xiaofei Wang*, Ran Zhou*, Yanzhen Xiong, Lingling Zhou, Xiang Yan, Manli Wang, Fan Li, Chuanxing Xie, Yiming Zhang, Zongyao Huang, Chaoqiong Ding, Kaidou Shi, Weida Li, Yu Liu, Zhongwei Cao, Zhen-Ning Zhang, Shengtao Zhou, Chong Chen, Yan Zhang#, Lu Chen#, Yuan Wang# . Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma. Cell Research. 2021, 31(6): 684-702.

4. Lulu Gong, Lining Cao, Zhenmin Shen, Li Shao, Shaorong Gao, Chao Zhang#, Jianfeng Lu#, Weida Li#. Materials for Neural Differentiation, Trans-Differentiation, and Modeling of Neurological Disease. Advanced Materials. 2018, 30(17): e1705684.

5. Lining Cao, Rui Hu, Ting Xu, Zhen-Ning Zhang, Weida Li, Jianfeng Lu. Characterization of Induced Pluripotent Stem Cell-derived Human Serotonergic Neurons [J]. Front Cell Neurosci, 2017, 11: 131.

6. Sihan Lv, Jian Li, Xinchen Qiu, Weida Li, Chao Zhang, Zhen-Ning Zhang#, Bing Luan#. A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses. Cell Death & Differentiation. 2017, 24(3): 492-9.

7. Claudia Cavelti-Weder*, Weida Li*, Adrian Zumsteg, Marianne Stemann-Andersen, Yuemei Zhang, Takatsugu Yamada, Max Wang, Jiaqi Lu, Agnes Jermendy, Yong Mong Bee, Susan Bonner-Weir, Gordon C Weir, Qiao Zhou. Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice. Diabetologia. 2016, 59(3): 522-32.

8. Sihan Lv, Xinchen Qiu, Jian Li, Weida Li, Chao Zhang, Zhen-Ning Zhang#, Bing Luan#. Suppression of CRTC2-mediated hepatic gluconeogenesis by TRAF6 contributes to hypoglycemia in septic shock. Cell Discovery. 2016, 2: 16046.

9. Claudia Cavelti-Weder, Weida Li, Adrian Zumsteg, Marianne Stemann, Takatsugu Yamada, Susan Bonner-Weir, Gordon Weir, Qiao Zhou. Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes. Curr Pathobiol Rep. 2015, 3(1): 57-65.

10. Weida Li*, Claudia Cavelti-Weder*, Yingying Zhang*, Kendell Clement, Scott Donovan, Gabriel Gonzalez, Jiang Zhu, Marianne Stemann, Ke Xu, Tatsu Hashimoto, Takatsugu Yamada, Mio Nakanishi, Yuemei Zhang, Samuel Zeng, David Gifford, Alexander Meissner, Gordon Weir, Qiao Zhou. Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells. Nature Biotechnology. 2014, 32(12): 1223-30.

11. Weida Li*, Mio Nakanishi*, Adrian Zumsteg, Matthew Shear, Christopher Wright, Douglas A Melton, Qiao Zhou. In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. Elife. 2014, 3: e01846.

12. Xiaochen Wang#, Weida Li, Dongfeng Zhao, Bin Liu, Yong Shi, Baohui Chen, Hengwen Yang, Pengfei Guo, Xin Geng, Zhihong Shang, Erin Peden, Eriko Kage-Nakadai, Shohei Mitani, Ding Xue#. Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nature cell biology. 2010, 12(7): 655-64.

13. Weida Li, Wei Zou, Dongfeng Zhao, Jiacong Yan, Zuoyan Zhu, Jing Lu, Xiaochen Wang. C. elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5. Development. 2009, 136(14): 2445-55.

14. Qun Lu*, Yan Zhang*, Tianjing Hu*, Pengfei Guo, Weida Li, Xiaochen Wang. C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells. Development. 2008, 135(6): 1069-80.

15. James J Cronican, Kevin T Beier, Tina N Davis, Jen-Chieh Tseng, Weida Li, David B Thompson, Allen F Shih, Erin M May, Constance L Cepko, Andrew L Kung, Qiao Zhou, David R Liu. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo [J]. Chem Biol, 2011, 18(7): 833-8.

16. Wei Zou*, Qun Lu*, Dongfeng Zhao, Weida Li, James Mapes, Yuting Xie, Xiaochen Wang. Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells [J]. PLoS Genet, 2009, 5(10): e1000679.

17. Sihan Lv, Xinchen Qiu, Jian Li, Jinye Liang, Weida Li, Chao Zhang, Zhen-Ning Zhang#, Bing Luan#. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism [J]. J Endocrinol, 2017, 234(2): 73-87.

18. Takatsugu Yamada, Claudia Cavelti-Weder, Francisco Caballero, Philippe A Lysy, Lili Guo, Arun Sharma, Weida Li, Qiao Zhou, Susan Bonner-Weir, Gordon C Weir. Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing beta-Like Cells [J]. Endocrinology, 2015, 156(6): 2029-38

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