个人简介：

   本科就读于上海医科大学（现复旦大学），毕业后曾任青岛大学医学院附属医院住院医师。研究生阶段就读于中国科学院上海生化细胞所（现中国科学院分子细胞科学卓越创新中心），师从丁小燕研究员，获发育生物学博士学位。博士后期间合作导师为英国医学科学院院士、巴斯大学JMW Slack教授。曾任美国明尼苏达大学医学院Research Associate、助理教授，现为同济大学生命科学与技术学院教授、脊柱脊髓损伤再生修复教育部重点实验室（同济大学）研究员。

研究方向为器官再生机理及诱导哺乳动物器官再生途径。主要研究内容为爪蛙、蝾螈与小鼠动物器官再生的细胞及分子生物学、表观遗传及代谢调控机制，以及干细胞多能性调控与前体细胞分化机制。实验室致力于利用前体细胞移植促进器官损伤修复。相关成果发表于Developmental Cell、Cell Reports、Nature Communications、Cell Discovery等知名学术期刊。

课题组成员：

助理研究员1人，博士研究生4人，硕士研究生2人

发表论文：

1. Wang S, Li C, Fan W, Chen T, Xu W, Hu X, Wu Z, Xiao Z, LIN G*, Ma B*, and Cheng L* (2025). Neurotrophin-3/chitosan inhibits cuproptosis-related genes to enable functional recovery after spinal cord injury. Int. J. Biol. Macromol. 310, 143403. 10.1016/j.ijbiomac. 2025. 143403.

2. Wang R, Chen Y, Han J, Ye H, Yang H, Li Q, He Y, Ma B, Zhang J, Ge Y, Wang Z, Sun B, Liu H, Cheng L*, Wang Z*, Lin G*. (2024). Selectively targeting the AdipoR2-CaM-CaMKII-NOS3 axis by SCM-198 as a rapid-acting therapy for advanced acute liver failure. Nat Commun 15, 10690. https://doi.org/10.1038/s41467-024-55295-7.

3. Chen Y, Chen Y, Li Q, Liu H, Han J, Zhang H, Cheng L, and LIN G*. (2023). Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells. Cell Rep. 42, 113308. https://doi.org/10.1016/j.celrep.2023.113308.

4. Wu Z, Zhu R, Yu Y, Wang J, Hu X, Xu W, Ren Y, Li C, Zeng Z, Ma B, Xie N, Lin G, Ma B, Zhu R, Ye K, Cheng L. (2023). Spinal cord injury-activated C/EBPβ-AEP axis mediates cognitive impairment through APP C586/Tau N368 fragments spreading. Prog. Neurobiol. 227. https://doi.org/10.1016/j.pneurobio.2023.102467.

5. Liu J, Liu J, Li M, Zhou L, Kong W, Zhang H, Jin P, Lu F, LIN G*, and Shi L*. (2023). Division of developmental phases of freshwater leech Whitmania pigra and key genes related to neurogenesis revealed by whole genome and transcriptome analysis. BMC Genomics 24. https://doi.org/10.1186/s12864-023-09286-5.

6. Yang L, Chen Y, Liu H, Liu Y, Yuan F, Li Q and Lin G* (2022) Evi5 is required for Xenopus limb and tail regeneration. Front. Cell Dev. Biol. 10:1027666. doi: 10.3389/fcell.2022.1027666

7. Wang X, Xue S, Lei X, Li L, Li X, Fu Y, Zhang C, Zhang H, Wang M, Lin G*, Zhang C*, Guo J*. (2022) Pharmacological evaluation of MRAP proteins on axolotl neural melanocortin signaling. Front. Endocrinol. 13:820896. doi: 10.3389/ fendo.2022.820896. 

8. Tai X, Xue S, Zhang C, Liu Y, Chen   J, Han Y, Lin G*, Zhang C*. Pharmacological evaluation of MRAP proteins on   Xenopus neural melanocortin signaling. J Cell Physiol. 2021 Jan 31. doi: 10.1002/jcp.30306. PMID: 33521982.

9. Ding X, Li Z, Lin G, Li W & Xue L. Toll-7 promotes tumour growth and invasion in Drosophila. Cell Prolif., e13188 (2022).

10. Xu Y, Li L, Zheng J, Wang M, Jiang B, Zhai Y, Lu L, Zhang C, Kuang Z, Yang X, Jin L*, Lin G*, Chao Zhang*. Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis. Endocrine Connections. 2021, 10(11): 1477-1488.

11. Wu C, Ding X, Li Z, Huang Y, Xu Q, Zou R, Zhao M, Chang H, Jiang C, La X, Lin G, Li W, Xue L. CtBP modulates Snail-mediated tumor invasion in Drosophila. Cell Death Discov 2021, 7(1):202. doi: 10.1038/s41420-021-00516-x.

12. Tai X, Xue S, Zhang C, Liu Y, Chen J, Han Y, Lin G*., Zhang C*.: Pharmacological evaluation of MRAP proteins on Xenopus neural melanocortin signaling. J Cell Physiol 2021, 236(9):6344-6361. PMID: 33521982.

13. Xu H, Zhang H, Fang Y, Yang H, Chen Y, Zhang C*, Lin G*. Activation of the Melanocortin-4 receptor signaling by α-MSH stimulates nerve-dependent mouse digit regeneration. Cell Regeneration, 2021 May 3;10(1):19. doi: 10.1186/s13619-021-00081-9.

14. Li L, Xu Y, Zheng J, Kuang Z, Zhang C, Li N, Lin G*, Zhang C*. Pharmacological modulation of dual melanocortin-4 receptor signaling by melanocortin receptor accessory proteins in the Xenopus Laevis. J Cell Physiol. 2021;236(8):5980–5993. https://doi.org/10.1002/jcp.30280. 【6.384】

15. Shen J, Hu L, Yang L, Zhang M, Sun W, Lu X, Lin G, Huang C, Zhang X, Chin YE. (2020) Reversible Acetylation Modulates Dishevelled-2 Puncta Formation in Canonical Wnt Signaling Activation. Signal Transduct Target Ther. 2020 Jul 6;5(1):115. doi: 10.1038/s41392-020-00229-0.

16. Lin G*, Chen Y. Limb regeneration under check by the nervous system. (2018) Chinese J Cell Biol. DOI: 10.11844/cjcb.2018.11.0202.

17. Zhang M, Chen Y, Xu H, Yang L, Yuan F, Li L, Xu Y, Chen Y*, Zhang C*, and Lin G* (2018). Melanocortin receptor 4 signaling regulates vertebrate limb regeneration. Dev Cell. August 20, 2018.46:397-409.

18. Zhang M, Yang L, Yuan F, Chen Y, and Lin G*. Dicer inactivation stimulates limb regeneration ability in Xenopus laevis. Wound Repair and Regeneration. 2018. 26:46-53.

19. Chen Y, Xu H, Lin G*. Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse. Cell Discovery. December 19, 2017 (3), 17046; doi:10.1038/celldisc.2017.46.

20. Lin H, Zhu X, Chen G, Song L, Gao L, Khand A, Chen Y, Lin G* and Tao Q*. KDM3A- mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis. Development 2017, 144:3674-3685.

21. Pai V, Lemire J, Chen Y, Lin G, Levin M. Local and long-range endogenous resting potential gradients antagonistically regulate apoptosis and proliferation in the embryonic CNS. Intl J Dev Biol, 2015, 59:327~340.

22. Pai V, Lemire JM, Pare JF, Lin G, Chen Y and Levin M. Endogenous gradients of resting potential instructively pattern neural tissue via Notch signalling. J Neurosci, 2015, 35 (10): 4366– 4385.

23. Shi X, Jai R, Zirbes K, Gong W, Lin G, Kyba M, Thomson J, Koyano-Nakagawa N and Garry D. Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages Dev Biol, 2014, 389 (2): 208–218.

24. Chen Y*, Lin G*. Xenopus model for regeneration. In Xenopus Development, Edited by Kubiak J & Kloc M. Willy-Blackwell Publishing (book chapter). 2014, 2014-6-3.

25. Leng H, Lin G* and Chen Y*. Cellular Origins of Amphibian Regeneration. Progenitor Cells: Biology, Characterization and Potential Clinical Applications, Edited by Horton P. and Lawrence B. Nova Publishers, New York, 2013, (book chapter).

26. Lin G#*, Chen Y#. and Slack JMW*. Imparting regenerative capacity to limbs by progenitor cell transplantation. Dev Cell, 2013 24(1): 41-51.

27. Lin G*, Chen Y. and Slack JMW*. Transgenic analysis of signaling pathways required for Xenopus tadpole spinal cord and muscle regeneration. Anat Rec, 2012, 295(10): 1532-1540.

28. Chen Y, Lin G, Chen Y, Fok A and Slack JMW*. Micro-computed tomography for visualizing limb skeletal regeneration in young Xenopus frogs. Anat Rec, 2012, 295(10): 1562-1565.

29. Lin G and Slack JMW*. Requirement for Wnt and FGF signaling in Xenopus tadpole tail regeneration. Dev Biol, 2008, 316(2): 323-335.

30. Slack JMW*, Lin G and Chen Y. The Xenopus tadpole: a new model for regeneration research. Cell Mol Life Sci, 2008, 65(1): 54-63.

31. Lin G, Chen Y and Slack JMW*. Regeneration of neural crest derivatives in the Xenopus tadpole tail. BMC Dev Biol, 2007, 7: 56.

32. Chen Y, Lin G. and Slack JMW*. Control of muscle regeneration in the Xenopus tadpole tail by Pax7. Development, 2006, 133(12): 2303-13.

33. Lin G, Geng X, Chen Y, Qu B, Wang F, Hu R and Ding X*.T-box binding site mediates the dorsal activation of myf-5 in Xenopus gastrula embryos.. Dev Dyn, 2003, 226(1): 51-8.

34. Geng X, Xiao L, Lin G, Hu R, Wang JH, Rupp RA and Ding X*. Lef/Tcf-dependent Wnt/beta- catenin signaling during Xenopus axis specification.FEBS Lett, 2003, 547(1-3): 1-6.

35. Chen Y#, Lin G#, Hu R, Chen Y and Ding X*. Activin/Nodal signals mediate the ventral expression of myf-5 in Xenopus gastrula embryos. Biochem Biophys Res Commun, 2003, 310(1): 121-7.

36. Wu K, Weng Z, Tao Q, Lin G, Wu X, Qian H, Zhang Y, Ding X*, Jiang Y*, Shi YE*. Stage- specific expression of breast cancer-specific gene gamma-synuclein. Cancer Epidemiol Biomarkers Prev, 2003, 12(9): 920-5.