教授
汪世龙
发布时间：2019-05-08
姓 名：汪世龙
学 位：博士
导师情况：博士生导师
研究领域：生物学
研究方向：
1.纳米材料对干细胞的分化和更新研究2.纳米材料作为治疗哮喘、炎症、肿瘤等药物载体的研制
3.脊髓损伤修复的纳米仿生支架研制
E-mail：wsl@ tongji.edu.cn
联系电话：021-65982595
通讯地址：上海市四平路1239号，同济大学生命科学与技术学院 医学大楼1119室（200092）
个人简介：
现任上海市第十三届政协委员，民建市委第十三届委员会常委，民建同济大学委员会第四届主委，曾担任国家自然科学基金委员会第十三、十四届、2014年、2016年生命科学部专家评审组成员，第九、十、十一届中国生物化学与分子生物学理事、第一、二、三届蛋白质专委会委员、上海市生物化学与分子生物学学会第十、十一届理事， 十二届副理事长、常务理事。1988年7月毕业于阜阳师范学院获学士学位，1988年7月至1990年8月在安徽科技学院任教，1996年6月毕业于中国科技大学获博士学位，1996年6月来同济大学工作至今。其间1999年9月至2000年5月在杨浦区科委挂职锻炼，任杨浦区科委副主任，2000年5月至2002年1月在美国Cornell University生物化学系 从事博士后研究工作。2006年4月至2016年9月任生命科学与技术学院副院长。已主持或参与国家、省部级项目30余项，已在国外核心杂志上发表被SCI收录的学术论文130余篇，主编出版60余万字的“蛋白质化学”教材一本，申请专利10余项，授权专利6项，已指导出站博士后3名，毕业博士生21名，硕士生40余名。
组内成员（包括学生）：
课题组工作人员：
孙晓宇 副教授 硕士生导师在站博士后： 吴斌
在读博士研究生：刘强、王照洁、静国欣、杨林楠、杨荔、李锋、程明荣
在读硕士研究生：徐子平、华佳慧、牛金童、孙飞越
希望招生范围：
欢迎国内外有志于生物材料、干细胞和化学合成研究的青年学子报考硕士生、博士生和从事博士后研究。
主要研究成果
教学成果：
1. 2007年获上海市育才奖。2. 承担的本科生课程“蛋白质化学”，被评为同济大学精品课程和上海市重点建设课程，主编出版了60余万字的“蛋白质化学”教材，“蛋白质研究”获研究生优质课程建设，教材获2015年上海市优秀教材。
3. 指导的博士生李昂、李坤、王瑾获同济大学优秀博士生论文。
4. 指导学生参加第十届全国“挑战杯”比赛，作品“高温高产酒精酵母菌种的优化”获上海市二等奖。
正在承担的项目:
1. 2007年获上海市育才奖。2. 承担的本科生课程“蛋白质化学”，被评为同济大学精品课程和上海市重点建设课程，主编出版了60余万字的“蛋白质化学”教材，“蛋白质研究”获研究生优质课程建设，教材获2015年上海市优秀教材。
3. 指导的博士生李昂、李坤、王瑾获同济大学优秀博士生论文。
4. 指导学生参加第十届全国“挑战杯”比赛，作品“高温高产酒精酵母菌种的优化”获上海市二等奖。
论文发表（近5年来发表的代表性论文）：
1.Linnan Yang, Jing Sun, Qiang Liu, Rongrong Zhu, Qiannan Yang, Jiahui Hua, Longpo Zheng, Kun Li, Shilong Wang,* and Ang Li*，Synergetic Functional Nanocomposites Enhance Immunotherapy in Solid Tumor via Remodeling Immunoenvironment，Advanced Science. 2019, 1802012. If=12. 441
2.Guoxin Jing, Zhaojie Wang, Xizhen Zhuang, Xiaolie He, Huijun Wu,Qingxiu Wang, Liming Cheng, Zhongmin Liu, Shilong Wang**, Rongrong Zhu* Suspended graphene oxide nanosheets maintain the self-renewal of mouse embryonic stem cells via down-regulating the expression of Vinculin，Biomaterials，2018,171,1-11。If=8.806
3.Zhaojie Wang1, Peng Liang1, Xiaolie He1, Bin Wu1, Qiang Liu1, Ziping Xu1,Zhongmin Liu1, Yechang Qian*2,Shilong Wang*1, Rongrong Zhu* Etoposide loaded layered double hydroxide nanoparticles reversing chemoresistance and eradicating human glioma stem cells in vitro and in vivo，Nanoscale, 2018, 10, 13106–13121 If=7.233
4.Qiang Liu, Jiao Wang, Linnan Yang, Xiaofei Xia, Mei Wang, Shengguang Chen, Rongrong Zhu, Qingxiu Wang, Xianzheng Wu and Shilong Wang*，Facile Synthesis by a Covalent Binding Reaction for pH-responsive Drug Release of Carboxylated Chitosan Coated Hollow Mesoporous Silica Nanoparticles ，IET Nanobiotechnol., 2018, 12(4),446-452. If=2.059
4.Qiang Liu, Jiao Wang, Linnan Yang, Xiaofei Xia, Mei Wang, Shengguang Chen, Rongrong Zhu, Qingxiu Wang, Xianzheng Wu and Shilong Wang*，Facile Synthesis by a Covalent Binding Reaction for pH-responsive Drug Release of Carboxylated Chitosan Coated Hollow Mesoporous Silica Nanoparticles ，IET Nanobiotechnol., 2018, 12(4),446-452. If=2.059
5.Bin Wu, Rongrong Zhu, Mei Wang, Peng Liang, Yechang Qian* and Shilong Wang*，Fluorescent carbon dots from antineoplastic drug etoposide for bioimaging in vitro and in vivo，Journal of Materials Chemistry B，2017 If=4.543
6.Xiaolie He, Li Yang, Mei Wang, Xizhen Zhuang, Ruiqi Huang, Rongrong Zhu*, Shilong Wang*，Targeting the Endocannabinoid/CB1 Receptor System For Treating Major Depression Through Antidepressant Activities of Curcumin and DexanabinolLoaded Solid Lipid Nanoparticles, cellular physiology and biochemistry, 2017;42:2281-2294 , If=5.104
7.Liang Wang‡ ， Bin Wu‡ ， Weitao Li, Zhen Li, Jing Zhan, Bijiang Geng, Shilong Wang*， Dengyu Pan,* Minghong Wu*，Industrial production of ultra-stable sulfonated graphene quantum，dots for Golgi apparatus imaging，Journal of Materials Chemistry B， Journal of Materials Chemistry B , 2017, 5, 5355-5361 If=4.543
8.Shan Jiang, Rongrong Zhu, Xiaolie He, Jiao Wang, Mei Wang, Yechang Qian*, Shilong Wang* Enhanced Generation of Reactive Oxygen Species from Curcumin induce a Remarkable Photocytotoxicity Delivered by Solid Lipid Nanoparticles，International Journal of Nanomedicine, 2017:12,167-178 If=4.32
9.Jiao Wang, Yue Wang, Qiang Liu, Linnan Yang, Rongrong Zhu, Chengzhong Yu**, Shilong Wang** Rational Design of Multifunctional Dendritic Mesoporous Silica Nanoparticles to Load curcumin and Enhance Efficacy for Breast Cancer Therapy，ACS Applied Materials & Interfaces，2016 If=8.097
10.Zhu, R., Wang, Q., Zhu, Y., Wang, Z., Zhang, H., Wu, B., Wu, X., Wang, S., pH sensitive nano layered double hydroxides reduce the hematotoxicity and enhance the anticancer efficacy of etoposide on nonsmallcell lung cancer, Acta Biomaterialia Acta Biomaterialia, 2016, 29: 320–332 If=6.02511.Yanjing Zhu, Rongrong Zhu *, Mei Wang, Xiaolie He, Yechang Qian*,Shilong Wang*,Anti-metastatic and Anti-angiogenic activities of Core-shell SiO2@LDH loaded with Etoposide in Non-small Cell Lung Cancer, advanced science，2016， If=12. 441
12.Hongjian He, Mingyu Liu, Junjie Wei, Ping Chen,* Shilong Wang,* and Qigang Wang* Hydrogel with Aligned and Tunable Pore Via “Hot Ice” Template Applies as Bioscaffold，Adv. Healthcare Mater. 2016, DOI: 10.1002/ adhm If=4.88
13.Xiaolie He#, Yanjing Zhu#, Mei Wang, Guoxin Jing, Rongrong Zhu* and Shilong Wang*,Antidepressant effects of curcumin and HU-211 co-encapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression, Int J Nanomedicine, 2016. If=4.32
14.Qing Wu，Zhaoqi Wang, Haixia Zhang, Rongrong Zhu, Shilong Wang* and Qigang Wang*, Fe3O4@Nanogel via UOx/HRP Initiated Surface Polymerization for pHSensitive Drug Delivery. RSC Advances, 2016,6(58):53170-53174. If=3.289
15.Haixia Zhang, Yanjing Zhu, Xiaoyu Sun, Xiaolie He, Mei Wang, Zhaoqi Wang, Qingxiu Wang, Rongrong Zhu* and Shilong Wang*， Curcumin Loaded Layered Double Hydroxide Nanoparticles-Induced Autophagy for Reducing Glioma Cell Migration and Invasion，J. Biomed.Nanotechnol. 2016，If=3.929
16.Tingting Qian, MeiWang , JiaoWang, Rongrong Zhu, Xiaolie He, Xiaoyu Sun, Dongmei Sun, Qingxiu Wang*, ShiLongWang*，Transient spectra study on photo-dynamics of Curcumin， Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2016: 16638–43。 If=2.653
17.Jiao Wang, Haoyue Wang, Rongrong Zhu, Qiang Liu, Jian Fei*, Shilong Wang *, Anti- inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1b transgenic mice subjected to the lipopolysaccharide-induced sepsis. Biomaterials ,2015,53, 475-483. If=8.557
18.Youjun Wu, Rongrong Zhu, Yang Zhou, Jun Zhang, Wenrui Wang, Xiaoyu Sun,Xianzheng Wu, Liming Cheng, Jing Zhang* and Shilong Wang*,Layered double hydroxide nanoparticles promote self-renewal of mouse embryonic stem cellsthrough the PI3K signaling pathway, Nanoscale, 2015, 7：11102–11114 If=7.394
19.Youjun Wu, Rongrong Zhu, Xin Ge,Xiaoyu Sun, Zhaoqi Wang, Wenrui Wang, Mei Wang, Hui Liu* & Shilong Wang*,Size dependent effects of layered double hydroxide nanoparticles on cellular functions of mouse embryonic stem cells, Nanomedicine, 2015, 10(23):3469-82. If= 5.413
20.Yanjing Zhu, Youjun Wu, Haixia Zhang, Zhaoqi Wang, Yechang Qian*, Rongrong Zhu*, Shilong Wang*, The enhanced anti-metastasis efficiency of etoposide by the delivery of LDH nanoparticles through caveolae-mediated cellular uptake and the regulation of mTOR/AKT and STAT pathways, J. Biomed.Nanotechnol. 2015, 11（12）：2158-2168, If=5.338
21.Jiao Wang, Rongrong Zhu, Dongmei Sun, Xiaoyu Sun, Zhengsong Geng, Hui Liu*, Shi-Long Wang* Intracellular Uptake of Curcumin-Loaded Solid Lipid Nanoparticles Exhibit Anti-inflammatory Activities Superior to Those of Curcumin through the NF-B Signaling Pathway, J. Biomed. Nanotechnol. 2015, 11, 403–415 If=5.338
22.Wen-Rui Wang, Ang Li, Wei Mei, Rong-Rong Zhu, Kun Li, Xiao-Yu Sun, Ye-Chang Qian* and Shi-Long Wang*, Dexamethasone sodium phosphate intercalated layered double hydroxides and their therapeutic efficacy in a murine asthma model, RSC Adv., 2015, 5, 23826–23834 If=3. 84
23.Dongmei Sun, Haibao Peng, Shilong Wang* and Dazhang Zhu* Synthesis of CaCO3 Nanobelts for Drug Delivery in Cancer Therapy，Nanoscale Research Letters, 2015, 10:239 doi:10.1186/s11671-015-0948-6，If=2.779
24.Chenchen Zhang, Shan Jiang, Kun Li, Mei Wang, Rongrong Zhu, Xiaoyu Sun, Qingxiu Wang, ShiLong Wang *, The triplet state of tanshinone I and its synergic effect on the phototherapy of cancer cells with curcumin，Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2015, 150（5）：181–186, If=2.353
授权和申请发明专利：
1.汪世龙；孙晓宇; 朱融融；吴又君，无机纳米材料层状双氢氧化物在小鼠胚胎干细胞培养中的应用 2014.4.11 2034.4.11 中国 ZL 2014 1 0142469.9
2.汪世龙；朱融融；贺晓烈，固体脂质纳米粒作为抗抑郁药物载体的应用 2016. 4.26 中国 201610262638.1
3.汪世龙；朱融融；王兆琪，一种具有主动靶向肿瘤的纳米药物载体-贝伐单抗介导的SiO2 @LDH、制备方法及应用 2016.5.24 中国 201610346455.8
4.汪世龙；朱融融；静国欣，纳米氧化石墨烯在促进小鼠胚胎干细胞培养和自我更新中的应用 2016.9.13 中国 201610817382.6
5.汪世龙；史均；孙晓宇；王玫；何娇娟；林楠；王渊，抗HIV-I的多肽、其编码序列及其用途 2007.2.2 2027.2.2 中国 ZL 201010142581.4
6.程黎明；汪世龙；朱融融，一种促进神经再生修复脊髓损伤的纳米层状双氢氧化物-多因子综合体系 2018.2.8 中国 201810126426.X
汪世龙课题组2018年全体师生合影
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