姓        名：王译萱
学        位：博士
导师情况：博士生导师
研究领域：干细胞生物学，发育生物学

研究方向：

1. 人干细胞全能性及多能性调控的分子机理研究；

2. 基于人干细胞模型的早期胚胎发育模拟研究。

E-mail：wangyixuan@tongji.edu.cn

联系电话：021-65987363

通讯地址：上海市四平路1230号同济大学东区A座701

实验室网址：http://life.tongji.edu.cn/gaolab/

个人简介：

王译萱，国家“优秀青年科学基金项目”获得者；上海市“曙光学者”、“扬帆学者”、“晨光学者”。2006年本科毕业于北京大学生命科学学院，2011年博士毕业于清华大学北京协和医学院、北京生命科学研究所，现任同济大学生命科学与技术学院教授，博士生导师；青年百人计划特聘研究员；附属东方医院特聘研究员。

王译萱教授长期致力于人干细胞全能性及多能性调控的分子机理研究和基于人干细胞模型的早期胚胎发育模拟研究。建立多种干细胞模型，实现人工胚胎模型优化与围植入期发育模拟；阐明关键因子在全能性向原态多能性转变及原态建立中的作用机制；建立基于诱导多能干细胞与原态重编程体系的疾病研究与潜在治疗模型。近年论文以通讯作者发表于Nature Cell Biology，Cell Stem Cell， Cell Research，Nature Communications，PNAS等国际知名期刊。多篇论文入选封面文章；全能性调控相关研究获2023年上海市自然科学一等奖。主持多项国家自然科学基金面上项目及上海市项目，获得国家发明专利授权多项。

近年代表文章：

1. Bi Y, Hu J, Wu T, Ouyang Z, Lin T, Sun J, Zhang X, Xu X, Wang H, Wei K, Gao S*, Wang Y*. (*Corresponding Author)
Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability.
Nature Cell Biology 2026 Accepted

2. Zhang X, Xu Y, Wang X, Yan Z, Hu J, Wang R, Liu Y, Zhang Y, Wu L, Wang H, Gao S*, Wang Y*.  (*Corresponding Author)
Lipid metabolic remodeling shapes early human maternal-embryo interface function.
Science Bulletin 2026 May 14:S2095-9273(26)00524-4. doi: 10.1016/j.scib.2026.05.024.

3. Bi Y, Hu J, Wu T, Ouyang Z, Lin T, Sun J, Zhang X, Xu X, Wang H, Wei K, Gao S*, Wang Y*. (*Corresponding Author)
Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability.
Protein & Cell 2025 Oct 31;16(10):858-872. doi: 10.1093/procel/pwaf053. (Cover Story)

4. Zhu X, Chang Z, Xiao W, Zhang X, Ma M, Wu J, Hu J, Bi Y, Kou X, Zhao Y, Sheng Y, Dong B, Sun J, Chen C, Wu Y, Liu X, Ding W, Jia K, Yao Y, Sun L, Yu X, Wang H, Liu J*, Wang Y*, Gao S*, Gao Y*. (*Corresponding Author)
Cell Stem Cell 2025 Nov 6;32(11):1773-1791.e13. doi: 10.1016/j.stem.2025.10.003.

5. Liu K, Yan Z, Bai D, Jiang R, Bi Y, Ma X, Xiang J, Sheng Y, Dong B, Ning Z, Yi S, Liu Y, Lei X, Jia Y, Zhang Y, Zhang Y, Li Y, Wu T, Xi C, Liu S, Liu S, Chen J, Yin J, Kou X, Zhao Y, Wang H, Wang Y*, Wei K*, Gao S*, Liu W*.  (*Corresponding Author)
Modeling post-gastrula development via bidirectional pluripotent stem cells.
Cell Research 2025 Dec;35(12):954-969. doi: 10.1038/s41422-025-01172-x. (Cover Story)

6. Tu Z, Bi Y, Lin T, Wu T, Wang H, Li J, Huang G, Gao S*, Wang Y*.  (*Corresponding Author)
Intercellular crosstalk within human preimplantation lineages regulates trophectoderm specification.
Science Bulletin 2025 Nov 15;70(21):3484-3488. doi: 10.1016/j.scib.2025.06.003.

7. Wu Q, Xu J, Zeng J, Wang Y*, Yang P*.  (*Corresponding Author)
Exploration of evolutionary mechanisms shaping KZFP and retrotransposon interactions.
Science Bulletin 2024 Jul 15; S2095-9273 (24) 00503-6. doi: 10.1016/j.scib.2024.07.023.

8. Wu Q, Fang L, Wang Y*, Yang P*. (*corresponding author)
Unraveling the role of ZNF506 as a human PBS-pro-targeting protein for ERVP repression.
Nucleic Acids Research. 2023 Oct 27;51(19):10309-10325. doi: 10.1093/nar/gkad731.

9. Zhou J, Hu J, Wang Y*, Gao S*.(*corresponding author)
Induction and application of human naive pluripotency.
Cell Reports. 2023 Apr 11;42(4):112379. doi: 10.1016/j.celrep.2023.112379.

10. Tu Z, Bi Y, Zhu X, Liu W, Hu J, Wu L, Mao T, Zhou J, Wang H, Wang H, Gao S*, Wang Y*.(*corresponding author)
Modeling human pregastrulation development by 3D culture of blastoids generated from primed-to-naïve transitioning intermediates.
Protein & Cell. 2023 May 8;14(5):337-349. doi: 10.1093/procel/pwac041.

11.Liu K, Xu X, Bai D, Li Y, Zhang Y, Jia Y, Guo M, Han X, Liu Y, Sheng Y, Kou X, Zhao Y, Yin J, Liu S, Chen J, Wang H, Wang Y*, Liu W*, Gao S*. (*corresponding author)
Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm.
Protein & Cell. 2023 Apr 21;14(4):262-278. doi: 10.1093/procel/pwac029

12. Bi Y, Tu Z, Zhou J, Zhu X, Wang H, Gao S*, Wang Y*. (*corresponding author)
Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures.
Nature Communications. 2022 Jun 7;13(1):3147. doi: 10.1038/s41467-022-30924-1.

13. Yang B, Fang L, Gao Q, Xu C, Xu J, Chen ZX, Wang Y*, Yang P*. (*corresponding author)
Species-specific KRAB-ZFPs function as repressors of retroviruses by targeting PBS regions.
Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2119415119. doi: 10.1073/pnas.2119415119.

14. Bi Y, Tu Z, Zhang Y, Yang P, Guo M, Zhu X, Zhao C, Zhou J, Wang H, Wang Y*, Gao S*. (*corresponding author)
Identification of ALPPL2 as a naïve pluripotent state-specific surface protein essential for human naïve pluripotency regulation.
Cell Reports. 2020 Mar 30(11): 3917-3931. doi: 10.1016/j.celrep.2020.02.090.

15. Guo M, Zhang Y, Zhou J, Bi Y, Xu J, Xu C, Kou X, Zhao Y, Li Y, Tu Z, Liu K, Lin J, Yang P*, Gao S*, Wang Y*. (*corresponding author)
Precise temporal regulation of Dux is important for embryo development.
Cell Research. 2019 Nov 11: 956-959. doi: 10.1038/s41422-019-0238-4.