姓        名：魏珂

学         位：博士

导师情况：博士生导师

研究领域： 心脏发育与再生

E-mail： kewei@tongji.edu.cn

联系电话： 17798238346

通讯地址： 上海市杨浦区四平路1239号，同济大学生命科学与技术学院，邮编200092

个人简介：

魏珂，同济大学生命科学与技术学院教授，附属东方医院心脏病全国重点实验室特聘研究员。本科毕业于清华大学生物科学与技术系，于美国加利福尼亚大学洛杉矶分校分子细胞综合生理专业获得博士学位，后在美国桑福德伯纳姆普利贝司医学研究所进行博士后科学研究。入选国家高层次人才青年项目，主持并参与多项国家自然科学基金项目及科技部重点研发项目。主要研究方向为心脏发育与再生，通过基于干细胞来源心肌细胞的体外高内涵筛选和体内发育和心脏疾病模型，发现了调控心肌细胞成熟与增殖，肥大与萎缩等多种表型转换的新机制；为开发治疗心脏疾病、促进心脏再生的药物提供了新的方向。发表SCI论文40余篇，其中以第一作者及通讯作者发表包括Nature, Circulation, Cell Research, Cardiovasc Res, Protein & Cell在内的论文20余篇，并获得两项美国专利授权。

研究领域（具体内容）：
干细胞与再生生物学
心肌梗死疾病模型与转化医学
高内涵药物筛选

发表论文：

2026

Mengying Feng#, Yansong Tang#, Su Yao, Hongjie Zhang, Bilin Liu, Rongrong Huang, Shiqi Huang, Zhaohui Ouyang, Min Yuan, Rui Jiang, Dachun Xu, Guohua Gong, Ke Wei* “Inhibiting L-type calcium channel promotes cardiomyocyte proliferation through activating canonical Wnt signaling pathway” (2026) Acta Pharmacologica Sinica 47(4):917-931

2025

Rui Jiang#, Hao Wang#, Weina Zhang, Jiaxi Li, Shiqi Huang, Lingjiang Chen, Yuhan Min, Zhaohui Ouyang, Ying Jiang, Zhiyong Mao, Guizhu Wu*, Ke Wei*, Yu Chen* “DHT Ameliorates Cardiac Aging in Progeroid Mice by XRCC4-Mediated Genome Stabilization” (2025) Mechanisms of Ageing and Development 112141

Dandan Zhang#, Yansong Tang#, Wen Ye#, Danli Yang, Shengtang Qin, Juntao Liu, Nan Su, Rongrong Huang, Guangzheng Shi, Dachun Xu, Xiaochen Kou, Yanhong Zhao, Hong Wang, Shaorong Gao*, Ke Wei*, Lan Kang*, “Pkm1 is required for embryonic cardiomyocyte proliferation through energetic regulation of NFYa stability” (2025) National Science Review 13 (1), nwaf408 https://doi.org/10.1093/nsr/nwaf408

Kuisheng Liu#, Zihui Yan#, Dandan Bai#, Rui Jiang#, Yan Bi#, Xiangjun Ma#, Jiani Xiang, Yifan Sheng, Baoxing Dong, Zhiyuan Ning, Shanru Yi, Yingdong Liu, Xinyi Lei, Yanping Jia, Yan Zhang, Yalin Zhang, Yanhe Li, Tao Wu, Chenxiang Xi, Shanyao Liu, Shuyi Liu, Jiayu Chen, Jiqing Yin, Xiaochen Kou, Yanhong Zhao, Hong Wang, Yixuan Wang*, Ke Wei*, Shaorong Gao*, Wenqiang Liu*, “Modeling post-gastrula development via bidirectional pluripotent stem cells” (2025) Cell Research 35(12):954-969, doi.org/10.1038/s41422-025-01172-x

Rui Jiang, Jiayu Chen, Lijuan Pei, Shiqi Huang, Mengying Feng, Zhaohui Ouyang, Min Yuan, Yalin Zhu, Su Yao, Fenglian He, Hongjie Zhang, Xin Dong, Peng Xie*, Ke Wei*, “Myosin inhibition enhances cardiomyocyte cell cycle activity through SIRT1-NFAT-mediated H3K9me3 modification” (2025) European Journal of Cell Biology 104(3):151504

Jingjing He#, Yi Yang#, Rui Jiang#, Yanying Zheng#, Xianfa Yang, Xu Jiang, Xin Xue, Zhongzhou Yang, Naihe Jing, Hailong Cao*, Zhuojuan Luo*, Ke Wei*, Peng Xie*, Chengqi Lin* “Integration of single-cell and spatial transcriptomics by SEU-TCA reveals the spatial origin of early cardiac progenitors” (2025) Genome Biology 26(1):158

2024

Rui Jiang, Lijuan Pei, Hongjie Zhang, Fenglian He, Yuhan Min, Xinhang Li, Ke Wei* “miR-199a-3p suppresses Vldlr expression to promote cardiomyocyte proliferation” (2024) Acta Biochimica et Biophysica Sinica 57(7):1164-1174

Yihang Zhou#, Jihong Zheng#, Wenqi Song#, Xinyi Yan, Li Du, Zhonglin Ma, Yanbin Fu, Zhaohui Ouyang, Yuchen Xiao, Zhuoqun Liu, Feng Tian, Jason Wing Hon Wong, Jen Hao David Shih, Shikang Liang, Honglei Tian, Liu Liu, Ke Wei*, Chao Zhang*, Jiangtao Li*, Xiaozhu Wang* “OUTPOST: A comprehensive analysis software for whole-metagenome shotgun sequencing incorporating group stratification” (2024) iMetaOmics 2024:e29

Su Yao, Yalin Zhu, Fenglian He, Min Yuan, Rui Jiang, Hongjie Zhang, Yanbin Fu, Ke Wei* “JAK Activity Regulates Mesoderm Cell Fate by controlling MESP1 expression” (2024) European Journal of Cell Biology 103(4):151452

Xinhang Li, Yalin Zhu, Pilar Ruiz-Lozano*, Ke Wei* “Mitochondrial-to-nuclear communications through multiple routes regulate cardiomyocyte proliferation” (2024) Cell Regeneration 13(1), 2

2023

Lijuan Pei#, Zhaohui Ouyang#, Hongjie Zhang, Shiqi Huang, Rui Jiang, Bilin Liu, Yansong Tang, Mengying Feng, Min Yuan, Haocun Wang, Su Yao, Shuyue Shi, Zhao Yu, Dachun Xu, Guohua, Gong, Ke Wei* “Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair” (2023) Basic Research in Cardiology 119(1):169-192

Yansong Tang, Mengying Feng, Dachun Xu, Ke Wei* “Response by Tang et al to Letter Regarding Article, “Jmjd4 facilitates Pkm2 degradation in cardiomyocytes and is protective against dilated cardiomyopathy”” (2023) Circulation 148 (24), 1980-1981

Yu Chen#, Shiqi Huang#, Zhen Cui, Xiaoxiang Sun, Yansong Tang, Hongjie Zhang, Zhixi Chen, Rui Jiang, Weina Zhang, Xue Li, Jiayu Chen, Baohua Liu, Ying Jiang, Ke Wei*, Zhiyong Mao* “Impaired end joining induces cardiac atrophy in a Hutchinson–Gilford progeria mouse model” (2023) Proceedings of the National Academy of Sciences 120(47):e2309200120

Yansong Tang#, Mengying Feng#, Yang Su, Teng Ma, Hongjie Zhang, Hongchun Wu, Xiaoyu Wang, Shuyue Shi, Ying Zhang, Yawei Xu, Shijun Hu, Ke Wei*, Dachun Xu* “Jmjd4 facilitates Pkm2 degradation in cardiomyocytes and is protective against dilated cardiomyopathy” (2023) Circulation 147(22):1684–1704

Shuangshuang Zhao#, Qiuping Xu#, Yanqin Cui#, Su Yao, Sihui Jin, Qian Zhang, Zeyu Wen, Haihua Ruan, Xin Liang, Yanjie Chao, Sitang Gong, Philippe Sansonetti, Ke Wei*, Hong Tang*, Yaming Jiu* “Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection” (2023) Nature Communications 14(1), 478

Jing Zhang#, Zhaohui Ouyang#, Limei Xia, Qi Wang, Feng Zheng, Kun Xu, Yuexian Xing, Ke Wei*, Shaolin Shi*, Chaojun Li*, Jingping Yang* “Dynamic chromatin landscape encodes programs for perinatal transition of cardiomyocytes” (2023) Cell Death Discovery 9(1), 11

2022

王皓存，欧阳兆惠，魏珂* “心肌细胞的成熟及其转录调控” 中国细胞生物学学报 （2022） 44:8 1473–1483

Mengying Feng, Yansong Tang, Su Yao, Hongjie Zhang, Dachun Xu, Ke Wei* “PLK inhibitors identified by high content phenotypic screening promote maturation of human PSC-derived cardiomyocytes” (2022) Biochemical and Biophysical Research Communications 620 (2022) 113-120

Hongjie Zhang#, Lijuan Pei#, Zhaohui Ouyang, Haocun Wang, Xin Chen, Kai Jiang, Shiqi Huang, Rui Jiang, Yaozu Xiang, Ke Wei* “AP-1 activation mediates postnatal cardiomyocyte maturation” (2022) Cardiovascular Research 119(2), 536-550

Lijuan Pei, Hongjie Zhang, Meihui Zhang, Yixuan Wang*, Ke Wei* “Rcor2 Is Required for Somatic Differentiation and Represses Germline Cell Fate” (2022) Stem Cells International 2022:5283615

2021

Zhaohui Ouyang, Ke Wei* “miRNA in cardiac development and regeneration” (2021) Cell Regeneration 10 (1):1-21

Zhaohui Ouyang#, Shuangshuang Zhao#, Su Yao#, Jing Wang, Yanqin Cui, Ke Wei*, Yaming Jiu* “Multifaceted Function of Myosin-18, an Unconventional Class of the Myosin Superfamily” (2021) Frontiers in Cell and Developmental Biology 9;9:632445

Lei Gao#, Hongjie Zhang#, Jingyi Cui, Lijuan Pei, Shiqi Huang, Yaning Mao, Zhongmin Liu*, Ke Wei*, Hongming Zhu* “Single-cell transcriptomics of cardiac progenitors reveals functional subpopulations and their cooperative crosstalk in cardiac repair” (2021) Protein & Cell 12(2):152-157

Before 2020

Ying Tao, Hongjie Zhang, Shiqi Huang, Lijuan Pei, Mengying Feng, Xiaodong Zhao, Zhaohui Ouyang, Su Yao, Rui Jiang, Ke Wei* “miR-199a-3p Promotes Cardiomyocyte Proliferation by Inhibiting Cd151 Expression” (2019) Biochemical and Biophysical Research Communications 516(1): 28-36

Ke Wei#, Vahid Serpooshan#, Cecilia Hurtado, Marta Diez-Cuñado, Mingming Zhao, Sonomi Maruyama, Wenhong Zhu, Giovanni Fajardo, Michela Noseda, Kazuto Nakamura, Xueying Tian, Qiaozhen Liu, Andrew Wang, Yuka Matsuura, Paul Bushway, Wenqing Cai, Alex Savchenko, Morteza Mahmoudi, Michael D. Schneider, Maurice J. B. van den Hoff, Manish J. Butte, Phillip C. Yang, Kenneth Walsh, Bin Zhou, Daniel Bernstein, Mark Mercola & Pilar Ruiz-Lozano* “Epicardial FSTL1 Reconstitution Regenerates the Adult Mammalian Heart” (2015) Nature 525(7570): 479-485

Ke Wei#, Ramon Díaz-Trelles#, Qiaozhen Liu, Marta Diez-Cuñado, Maria-Cecilia Scimia, Wenqing Cai, Junko Sawada, Masanobu Komatsu, Joseph J. Boyle, Bin Zhou, Pilar Ruiz-Lozano*, and Mark Mercola* “Developmental origin of age-related coronary artery disease” (2015) Cardiovascular Research 107 (2): 287-294

(# Co-first authors; * corresponding authors)