个人简介：

      北京大学生物系学士，中国科学院上海细胞生物学研究所硕士，瑞士苏黎世大学分子生物学研究所博士，美国耶鲁大学医学院博士后。 历任耶鲁大学医学院副研究员 (Associate Research Scientist)，霍华德修斯医学研究院 (Howard Hughes Medical Institute) 研究专家 (Research Specialist)，自2008年9月起任同济大学生命科学与技术学院教授，博导，首席科学家。

研究领域：

      JNK信号通道在细胞增殖、迁移、凋亡、应激反应和个体衰老中起着至关重要的作用，其失调可导致发育缺陷和过早衰老，并和肿瘤发生和迁移、免疫失调、阿尔兹海默症及多种重要疾病的发生与发展密切相关。

      近年来，我们以果蝇为模式动物进行遗传筛选，找到了JNK信号通道上30多个新的基因，目前已分析鉴定其中部分基因，成果发表在Developmental Cell和Science 等国际顶级学术杂志。我们将继续研究其余的基因，探索它们在JNK信号通道中的分子功能，阐明其在细胞凋亡、个体衰老、癌症及阿尔兹海默症中的作用机制。

      选择是一种行为，也代表着智慧，其调控分子和作用机制仍有待破解。我们利用果蝇的择偶方式和取向，研究选择的分子机制以及调控选择的遗传因素。我们还建立了癌症和阿尔兹海默症的果蝇模型，并利用这些疾病模型筛选和检验各类中药成分对延缓衰老、治疗癌症和老年痴呆症等疾病的效果。

通讯作者论文：

1. X Guo, Z Li, X Zhu, M Zhan, C Wu, X Ding, K Peng, W Li, X Ma, Z Lv, L Lu and L Xue* (2022) A Coherent FOXO3-SNAI2 Feed-Forward Loop in Autophagy. PNAS 119:e2118285119.

2. Y Pan, W Li, Z Deng, Y Sun, X Ma, R Liang, X Guo, Y Sun, W Li, R Jiao and L Xue* (2022) Myc suppresses male-male courtship in Drosophila. EMBO J 41:e109905.

3. X Guo, X Ma, L Xue* (2022) A conserved interplay between FOXO and SNAI/Snail in autophagy. Autophagy. doi: 10.1080/15548627.2022.2063559.

4. X Ding, Z Li, K Peng, R Zou, C Wu, G Lin, W Li and L Xue* (2022) Snail regulates Hippo signaling-mediated cell proliferation and tissue growth in Drosophila. Open Biology. 12:210357.

5. X Ding, Z Li, G Lin, W Li and L Xue* (2022) Toll-7 promotes tumor growth and invasion in Drosophila. Cell Proliferation. 55:e13188.

6. Y Sun, Z Li, W Li and L Xue* (2022) Loss of Bicra impairs Drosophila learning and choice abilities. Neuroscience Letters. 769:136432.

7. C Wu, X Ding, Z Li, Y Huang, Q Xu, R Zou, M Zhao, H Chang, C Jiang, X La, G Lin, W Li, L Xue* (2021) CtBP modulates Snail-mediated tumor invasion in Drosophila. Cell Death Discovery. 7:202.

8. X Guo, YSun, T Azad, H J Rensburg, J Luo, S Yang, P Liu, Z Lv, M Zhan, L Lu, Y Zhou, X Ma, X Zhang, X Yang, L Xue* (2020) Rox8 promotes microRNA-dependent yki messenger RNA decay. PNAS 117:30520-30530.

9. L Zhuang, F Peng, Y Huang, W Li, J Huang, Y Chu, P Ren, Y Sun, Y Zhang, E Xue, X Guo, X Shen, L Xue* (2020) CHIP modulates APP-induced autophagy-dependent pathological symptoms in Drosophila. Aging Cell 19:e13070.

10. Z Li, C Wu, X Ding, W Li, L Xue* (2020) Toll signaling promotes JNK-dependent apoptosis in Drosophila. Cell Division 15:7.

11. C Wu, Z Li, X Ding, X Guo, Y Sun, X Wang, Y Hu Y, T Li, X La, J Li, J Li, W Li, L Xue* (2019) Snail modulates JNK-mediated cell death in Drosophila. Cell Death Disease. 10:893. I

12. S Zhang, X Guo, H Wu, Y Sun, X Ma, J Li, Q Xu, C Wu, Q Li, C Jiang, W Li, MS Ho, Z Lv, and L Xue* (2019) Wingless modulates activator protein-1-mediated tumor invasion. Oncogene. 38: 3871-3885.

13. Y Sun, D Zhang, X Guo, W Li, C Li, J Luo, M Zhou and L Xue* (2019) MKK3 modulates JNK-dependent cell migration and invasion. Cell Death Disease. 10:149.

14. Y Sun, D Zhang, C Li, J Huang, W Li, Y Qiu, A Mao, M Zhou and L Xue* (2019) Lic regulates JNK-mediated cell death in Drosophila. Cell Proliferation 52: e12593.

15. X Ma, X Guo, HE Richardson, T Xu and L Xue* (2018) POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation. PNAS 115:2150-2155.

16. X Wang, X Huang, C Wu and L Xue* (2018) Pontin/Tip49 acts as a novel regulator of JNK pathway. Cell Death Disease 9: 978.

17. X Wang, X Huang, C Wu and L Xue* (2018) Pontin/Tip49 negatively regulates JNK-mediated cell death in Drosophila. Cell Death Discovery 4:74.

18. X Wang, X Guo, Y Ma, C Wu, W Li and L Xue* (2018) APLP2 Modulates JNK-Dependent Cell Migration in Drosophila. BioMed Research International: Article ID 7469714.

19. X Ma, H Wang, J Ji, W Xu, Y Sun, W Li, X Zhang, J Chen and L Xue* (2017) Hippo Signaling Promotes JNK-dependent Cell Migration. PNAS 114:1934-1939.

20. X Ma, J Huang, Y Tian,Y Chen, Y Yang, X Zhang, F Zhang and L Xue* (2017) Myc Suppresses Tumor Invasion and Cell Migration by inhibiting JNK Signaling. Oncogene 36: 3159-3167.  

21. J Huang, Y Feng, X Chen, W Li and L Xue* (2017) Myc inhibits JNK-mediated cell death in vivo. Apoptosis 22:479-490.

22. P Ren, W Li and L Xue* (2017) GLYAT regulates JNK-mediated cell death in Drosophila. Scientific Reports 7:5183.

23. L Zhuang, Y Sun, M Hu, C Wu, X La, X Chen, Y Feng, X Wang, Y Hu and L Xue* (2016) Or47b plays a role in Drosophila males’ preference for younger mates. Open Biology 6: 160086.

24. S Zhang, X Guo, C Chen, Y Chen, J Li, Y Sun, C Wu, Y Yang, C Jiang, W Li and L Xue* (2016) dFoxO promotes Wingless signaling in Drosophila. Scientific Reports 6:22348.

25. X Ma, Y Chen, S Zhang, W Xu, Y Shao, Y Yang, W Li, M Li* and L Xue* (2016) Rho1–Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila. Oncogene 35, 846–855.

26. X Ma, Y Chen, W Xu, N Wu, M Li, Y Cao, S Wu, Q Li and L Xue* (2015) Impaired Hippo signaling promotes Rho1-JNK-dependent growth. PNAS 112:1065-70.

27. C Wu, Y Chen, F Wang, C Chen, S Zhang, C Li, W Li, S Wu and L Xue* (2015) Pelle Modulates dFoxO-Mediated Cell Death in Drosophila. PLOS Genetics 11:e1005589.

28. F Peng, Y Zhao, X Huang, C Chen, L Sun, L Zhuang and L Xue* (2015) Loss of Polo ameliorates APP-induced Alzheimer’s disease-like symptoms in Drosophila. Scientific Reports 5:16816.

29. Y Hu, Y Han, Y Shao, X Wang, Y Ma, E Ling and L Xue* (2015) Gr33a Modulates Drosophila Male Courtship Preference. Scientific Reports 5:7777.

30. X Ma, W Xu, D Zhang, Y Yang, W Li and L Xue* (2015) Wallenda regulates JNK-mediated cell death in Drosophila. Cell Death Disease 6, e1737.

31. S Zhang, C Chen, C Wu, Y Yang, W Li and L Xue* (2015) The canonical Wg signaling modulates Bsk-mediated cell death in Drosophila. Cell Death Disease 6, e1713.

32. C Wu, C Chen, J Dai, F Zhang, Y Chen, W Li, J Pastor-Pareja and L Xue* (2015) Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila. Open Biology 5: 140171.

33. L Li, P Li and L Xue* (2015) The RED domain of Paired is specifically required for Drosophila accessory gland maturation. Open Biology 5: 140179.

34. J Huang and L Xue* (2015) Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila. BioMed Research International: Article ID 623573.

35. X Wang, Y Ma, Y Zhao, Y Chen, Y Hu, C Chen, Y Shao and L Xue* (2015) APLP1 promotes dFoxO-dependent cell death in Drosophila. Apoptosis 20, 778-786.

36. X Wang, Z Wang, Y Chen, X Huang, Y Hu, R Zhang, M S Ho and L Xue* (2014) FoxO Mediates APP-Induced AICD-Dependent Cell Death. Cell Death Disease 5, e1233.

37. Y Hu, Y Han, X Wang and L Xue* (2014) Aging-related Neurodegeneration Eliminates Male Courtship Choice in Drosophila. Neurobiology of Aging 35, 2174-2178.

38. X Ma, W Li, H Yu, Y Yang, M Li, L Xue* and T Xu* (2014) Bendless modulates JNK-mediated cell death and migration in Drosophila. Cell Death Differentiation 21, 407-415.

39. H Yang, W Li, H Yu, R Yuan, Y Yang, K Pung, P Li and L Xue* (2013) Physiological Effects of L-Theanine on Drosophila melanogaster. Molecules 18, 13175-13187.

40. X Ma, Y Shao, H Zheng, M Li, W Li and L Xue* (2013) Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila. Cell Death Disease 4, e864.

41. X Ma, L Yang, Y Yang, M Li, W Li and L Xue* (2013) dUev1a Modulates TNF-JNK Mediated Tumor Progression and Cell Death in Drosophila. Development Biology 380, 211-221.

42. X Ma, J Huang, Y Yang, W Li and L Xue* (2012) NOPO Modulates Egr- induced JNK- independent cell death in Drosophila. Cell Research 22, 425-431.