学   位：博士

导师情况：博士生导师

研究领域：发育与功能基因组学

 E-mail：peng.yang@tongji.edu.cn

联系电话：021-65981189

通讯地址： 上海市赤峰路67号同济大学南校区实训楼509
实验室网址：http://yang-lab.tongji.edu.cn

个人简介：   

同济大学生命科学与技术学院长聘教授，国家青年海外高层次人才计划（第十五批），上海高层次人才计划（第八批），国家重点研发干细胞及转化研究重点专项青年首席科学家，上海市曙光学者，上海市启明星计划，中国遗传学会表观遗传分会委员，中国细胞学会染色质分会委员。担任国家重点研发会评，教育部青年长江学者函评，国家自然科学基金函评等评审。长期从事早期胚胎/胎盘发育异常及胚胎干细胞多能性的表观遗传及代谢机理研究。相关论文以第一／共同第一作者身份发表在Science、Cell、Cell Research、PNAS、Nucleic Acids Research、Trends in Genetics等国际权威期刊。主持多项国家及省部级科研项目，经费累计超过一千万元，其中国家自然科学基金五项，科技部重点研发干细胞专项一项，上海市项目两项。

近年代表文章：

1.Wu  Q, Xu J, Zeng J, Wang Y*, Yang P*.

Exploration of evolutionary mechanisms shaping KZFP and retrotransposon interactions.

Science Bulletin 2024; S2095-9273 (24) 00503-6. doi: 10.1016/j.scib.2024.07.023. 

(*Corresponding Author)

2.Wu Q, Fang L, Wang Y*, Yang P*. 

Unraveling the Role of ZNF506 as a human PBS-Pro-targeting protein for ERVP repression. 

Nucleic Acids Res.2023; Sep 11:gkad731. doi: 10.1093/nar/gkad731. (*Corresponding Author)

3.Yang B, Fang L, Gao Q, Xu C, Xu J, Chen Z, Wang Y*, Yang P*. 

Species-specific KRAB-ZFPs function as repressors of retroviruses by targeting PBS regions. 

PNAS.2022; 119(11):e2119415119. (*Corresponding Author)

4. Guo M, Zhang L, Zhou J, Bi Y, Xu J, Xu C, Kou X, Zhao Y, Li Y, Tu Z, Liu K, Lin J, Yang P*, Gao S*, Wang Y*. 

Precise temporal regulation of Dux is important for embryo development. 

Cell Res. 2019; ;29(11):956-959.(*Corresponding Author)

5. Patel A*, Yang P*, Tinkham M, Sun M, Wang Y, Hoang D, Wolf G, Horton J, Zhang X, Macfarlan TS, Cheng X. 

DNA conformation induces adaptable binding by tandem zinc finger proteins. 

Cell 2018;173(1): 221-233 (*Equal Contribution)

6. Yang P, Wang Y, Hoang D, Tinkham M, Patel A, Sun M, Wolf G, Baker M, Lai N, Cheng X, Shen J, Macfarlan T. 

A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568. 

Science 2017;356(6339): 757-759.

7. Yang P, Wang Y, Macfarlan T. 

The role of KRAB-ZFPs in retrotransposon repression and mammalian evolution. 

Trends in Genetics. 2017;33(11):871-881

8. Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, Chen S, Zhu B, Gao S. 

Rcor2 is a Subunit of the LSD1 Complex that Regulates ES Cell Property and Substitutes for Sox2 in Reprogramming

Somatic Cells to Pluripotency. 

Stem Cells 2011; 29(5):791-801.

9. Wang Y, Wu Q, Yang P, Wang C, Liu J, Ding W, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X. 

LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. 

Nat Commun. 2016;7:10481

10. Wolf G, Yang P, Füchtbauer A, Füchtbauer E, Silva A, Park C, Wu W, Nielsen A, Pedersen F, Macfarlan TS. 

The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses. 

Genes & Dev. 2015;29(5):538-54.

11. Yang P, Wu W, Macfarlan TS. 

Maternal histone variants and their chaperones promote paternal genome activation and boost somatic cell reprogramming. 

Bioessays. 2015;37(1):52-9.

12. Zhu X, Wang F, Zhao Y, Yang P, Chen J, Sun H, Liu L, Li W, Pan L, Guo Y, Kou Z, Zhang Y, Zhou C, He J, Zhang X, Li

J, Han W, Li J, Liu G, Gao S, Yang Z. 

A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice. 

PLoS Genetics. 2014;10(10):e1004589.

13. Jia G, Wang W, Li H, Mao Z, Cai G, Sun J, Wu H, Xu M, Yang P, Yuan W, Chen S, Zhu B. 

A systematic evaluation of the compatibility of histones containing methyl-lysine analogues with biochemical reactions. 

Cell Res. 2009; 19: 1217-1220.