报 告 人：尹晓磊 博士

主 持 人：高绍荣 教授

时    间：6月12日 上午10：00

地    点：医学大楼1102室

Research Focus

Stem cells hold great potential to regenerate damaged tissue through exerting their self-renewal and differentiation abilities. Adult stem cells, which exist in many tissues and organs in the body, could be used to restore healthy tissue when properly regulated. My research focuses on deciphering the mechanisms of the self-renewal and differentiation of adult stem cells, and developing strategies to treat diseases through controlling the behavior of adult stem cells. Using an Lgr5 intestinal stem cell organoid model, I identified small molecule combinations to regulate their behavior, which were further translated into the inner ear stem cell system to treat hearing loss.

Employment and Education

• 2014-present       Instructor in medicine, Harvard Medical School, USA
• 2010-2014           Postdoctoral associate, Massachusetts Institute of Technology, USA
• 2004-2009           Ph.D. in Cell Biology, Peking University, China
• 2000-2004           B.S. in Biological Sciences, Pekin University, China

Selected Publications

1. 1. McLean W#, Yin X#, Lu L, Lenz D, McLean D, Langer R, Karp JM, Edge A. Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells. Cell Reports. 2017 Feb 21. Cover Feature.
2. 2. Yin X., Mead BE, Safaee H, Langer R, Karp JM, Levy O. Engineering Stem Cell Organoids. Cell Stem Cell. 2016 Jan 7. Invited Review. Cover Feature.
3. 3. Yin X., Farin H.F., van Es JH., Clevers H., Langer R., Karp J.M. Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. Nature Methods. 2014 Jan:11.
4. 4. Zhao Y.#, Yin X.#, Qin H.#, Zhu F., Liu H., et al., Ding M., and Deng H., Two supporting factors greatly improve the efficiency of human iPS cell generation. Cell Stem Cell. 2008 Nov 6.