报 告 人：Guohua Gong, Ph.D

Center for Pharmacogenomics, School of Medicine, Washington University in St. Louis

主 持 人：高绍荣教授

时    间：2016年1月18日 上午10:15-11:15

地    点：医学大楼1102室

Research backgroud

Pakin-mediated quality control (mitophagy) has been recognized as a critical process to keep mitochondrial health. Heart depends upon mitochondrial ATP generated from available metabolic substrates. Increasing oxygen exchange in the early embryo provokes a change from anaerobic glycolysis to aerobic mitochondrial respiration. After birth, mitochondria respiration undergoes a further transition to fatty acid metabolism and small asymmetrical fetal cardiomyocyte mitochondria are supplanted by larger ovoid adult mitochondria. What is the mechanisms underlying cardiac mitochondrial plasticity?

Employment and Education

• 2013-2015       Postdoctoral Associate,Washington University in St. Louis, USA
• 2010-2013       Senior Fellow, University of Washington, USA
• 2006-2010       Ph.D., Biochemistry and Molecular Biology. Sichuan University, China.
• 2003-2006       M.S., Preventive Veterinary. Xinjiang Agricultural University, China.
• 1999-2003       B.S., Veterinary Medicine. Southwest University, China.
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Selected Publications

1. Gong GH et al. Parkin-Mediated Mitophagy Directs Perinatal Cardiac Mitochondrial Metabolic Maturation in Mice. Science. 2015, 350: aad2459. DOI: 10.1126/science.aad2459.
2. Gong GH et al. Mitochondrial Flash as A Novel Biomarker of Mitochondrial Respiration in The Heart. AJP Heart. 2015, 309: H1166-H1177.
3. Gong GH et al. Regulation of Metabolism in Individual Mitochondria during Excitation-Contraction Coupling. J Mol Cell Cardiol. 2014, 76:235-246.
4. Gong GH et al. Confocal Imaging of Single Mitochondrial Superoxide Flashes in Intact Heart or in vivo. J. Vis. Exp (JoVE). 2013, e50818, doi:10.3791/50818.
5. Wei-LaPierre*, L, Gong GH* et al. Respective Contribution of Mitochondrial Superoxide and pH to Mt-cpYFP Flash Activity.J Biol Chem. 2013, 288: 10567~ 10577.