Ph.D, Professor
School of Life Sciences and Technology, Tongji University
Telephone : 86-13621673548     
Email : zhiyong_mao@tongji.edu.cn

Education
2010-2012 Postdoc Fellow Advisor: Dr. Vera Gorbunova
                     UNIVERSITY OF ROCHESTER ROCHESTER, NY
2004- 2010 Ph.D., Cell and Molecular Biology Advisor: Dr. Vera Gorbunova
                     UNIVERSITY OF ROCHESTER ROCHESTER, NY
2002- 2004 M.S., Plant Biology Advisors: Dr. Zhili Liu & Dr. Pengfu Li
                     NANJING UNIVERSITY NANJING, CHINA
1998- 2002 B.S., Biological Science
                     NANJING UNIVERSITY NANJING, CHINA

Publications

1. Cao Y, Xu Y, Zhang L, Li Z, Jiang Y, Tian X, Seluanov A, Gorbunova V*, Mao Z*. Utilization of Rad51C promoter for transcriptional targeting of cancer cells. Oncotarget. 2014 Feb 19. Epub ahead of print. * Corresponding authors.
2.  Xu Y, Ohms SJ, Li Z, Wang Q, Gong G, Hu Y, Mao Z*, Shannon MF*, Fan JY*. Changes in the Expression of miR-381 and miR-495 Are Inversely Associated with the Expression of the MDR1 Gene and Development of Multi-Drug Resistance. PLoS One. 2013 Nov 26;8(11):e82062. * Corresponding authors.
3. Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, Mao Z, Nevo E, Gorbunova V, Seluanov A. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature. 2013 Jul 18;499(7458):346-9.
4. Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11800-5.
5. Mao Z, Ke Z, Gorbunova V, Seluanov A. Replicatively senescent cells are arrested in G1 and G2 phases. Aging (Albany NY). Jun;4(6):431-5.
6. Van Meter M, Mao Z, Gorbunova V and Seluanov A. Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. Aging (Albany NY). 2011 Sep;3(9):829-35.
7. Van Meter M, Mao Z, Gorbunova V and Seluanov A. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle. 2011 Sep. 15; 15:18.
8. Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V. SIRT6 promotes DNA repair under stress by activating PARP1. Science. 17 June 2011: 1443-1446.
9. Seluanov A, Mao Z, Gorbunova V. Analysis of DNA Double-Strand Break (DSB) Repair in Mammalian Cells. J Vis Exp. 2010 Sep 8;(43).
10. Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao Z, Catania KC, Gorbunova V. Naked mole-rat cells are hypersensitive to contact inhibition – a clue to extraordinary cancer resistance. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46): 19352-7.
11. Mao Z*, Jiang Y*, Liu X, Seluanov A, Gorbunova V. DNA repair by homologous recombination,but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia. 2009 Jul;11(7):683-691. * These authors contributed equally to this work.
12. Mao Z*, Bozzella M*, Seluanov A, Gorbunova V. DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle. 2008 Sep 15; 7:18, 1-5. * These authors contributed equally to this work.
13. Mao Z, Bozzella M, Seluanov A, Gorbunova V. Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst). 2008 Oct 1;7(10):1765-71.
14. Gorbunova V, Seluanov A, Mao Z, Hine C. Changes in DNA repair during aging. Nucleic Acids Res. 2007;35(22):7466-74.
15. Mao Z, Seluanov A, Jiang Y, Gorbunova V. TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13068-73.
16. He L, Mao Z, Zhu X, Huang H, Huang P. Cloning, expression and antibody preparation of transcription factor CTCF. Letters in Biotechnology. 2004,15(5). (In Chinese)
17. Li PF, Mao ZY, Rao XJ, Wang XM, Min MZ, Qiu LW and Liu ZL. Biosorption of uranium by lake-harvested biomass from a cyanobacterium bloom. Bioresour Technol. 2004 Sep;94(2):193-5.
18. Wang X, Zhao X, Mao ZY, Wang XM and Liu ZL. Neuroprotective effect of docosahexaenoic acid on glutamate-induced cytotoxicity in rat hippocampal cultures. Neuroreport. 2003 Dec 19;14(18):2457-61.

Conference Presentations

1. Vera Gorbunova, Zhiyong Mao, Christopher Hine, Amita Vaidya, Marina Feigenson, Andrei Seluanov. SIRT6 promotes DNA Repair under stress by mono-ADP-ribosylating PARP1. 39th Annual Meeting of the American Aging Association. 2010. Portaland, OR.
2. Andrei Seluanov, Christopher Hine, Jorge Azpurua, Marina Feigenson, Zhiyong Mao, Vera Gorbunova. Anticancer mechanisms in a long-lived rodent, the naked mole-rat. 39th Annual Meeting of the American Aging Association. 2010. Portaland, OR.
3. Zhiyong Mao, Christopher Hine, Andrei Seluanov, Amita Vaidya, Michael Bozzella, Vera Gorbunova. SIRT6 localizes to the sites of DNA double-strand breaks and stimulates repair under stressful conditions. 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology. 2009. Shanghai, China
4. Zhiyong Mao, Andrei Seluanov, Ying Jiang and Vera Gorbunova. TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. 10th Annual Midwest DNA Repair Symposium. 2008. Pittsburgh, PA.
5. Zhiyong Mao, Michael Bozzella, Andrei Seluanov and Vera Gorbunova. Nonhomologous end joining is a faster and more efficient pathway than homologous recombination in human cells. 10th Annual Midwest DNA Repair Symposium. 2008. Pittsburgh, PA.

Honors and Awards
2013 Shanghai Pujing Talents
2010 Cozzarelli Prize by National Academy of Sciences of the United States
2010 Honorable Mention for the 2010 Oustanding Dissertation Award in the Natural Sciences at the
University of Rochester
2009 Messersmith Fellowship at the University of Rochester
2009 GOG Travel Award at the University of Rochester
2008 Chinese Government Award for Outstanding Self-financed Students Abroad
2008 Award for Best Poster on Genetics Day at the University of Rochester