Education & Training:
B.S., Fuyang Normal College,1988
Ph.D., University of Science and Technology of China.1996
Postdoctoral Associate, Cornell University, 2002

Research Interests:
1, Nano drug carrier systems for targeting treatment and the bio-effect of nano materials
2. Regulation of stem cell differentiation by nanoparticles
3. The development of polypeptide and active compounds as molecular medicine
4, Study of biological molecules. The transient dynamics and their interactions

Research Description:
1.In view of the special properties of layered double hydroxides and solid lipid nanoparticles and some other nanoparticles, for a variety of types of preparation of nano materials, controlled release and targeting properties of nanoparticles on the discussion, attempts are made in the treatment of tumor. Some new forms of potential nano materials and the drugs are obtained, at the same time, the nano materials used as adjuvant and DNA vaccine vector are studied. 
2.We investigated the cellular effects of layered double hydroxides (LDHs) on mESCs. LDHs were proved to have the capability to promote the growth of ESCs and inhibit apoptosis elicited by leukaemia inhibitory factor (LIF) withdrawal. Moreover, the cells maintained the potential to differentiate into all three germ layers both in vitro and in vivo.
3.According to the mechanism of HIV-1 membrane fusion, we respectively design a series of peptides as inhibitors of HIV-1 membrane fusion from four aspects. That is to inhibit the gp160 cleavage by using the inhibitor of precursor processing enzyme; to use the analogue of CD4 peptide to inhibit the combine between gp120 and CD4; to use C-terminal polypeptide similar of gp41 to inhibit the conformational change of gp41 molecule. Research on combinatorial peptide activity center is formed by the combination of the above three kinds of polypeptide, and the exploration has achieved initial results. At the same time we study the generation of myocardial local endogenous H2S and the transmission mechanism of regulation. 
4.By using nanosecond transient laser flash photolysis apparatus developed by our own group and the Chinese Academy of Sciences Institute of Applied Physics, the interaction mechanisms of the relationship between transient behavior and the functions of important biological molecules and with other small molecule were explored.
Key Word: cancer treatment, nano carrier, stem cell differentiation, DNA vaccine vector

Representative Publication (less than 20 papers)：

1. Jin Wang, Rongrong Zhu,Bo Gao,Bin Wu,Kun Li, Xiaoyu Sun,Hui Liu, Shilong Wang * , The DNA vaccine delivery function of SiO2@ LDH  Nanoparticles on the activation of macrophage for the anti-HBV immune response enhancement  through NF-κB signaling pathway, Biomaterials, 2014, 35， 466-478， (IF：8.312)
2. Ang Li, Lili Qin, Wenrui Wang, Rongrong Zhu, Yongchun Yu, Hui Liu, Shi-Long Wang*， The use of layered double hydroxides as DNA vaccine delivery vector for enhancement of anti-melanoma immune response, Biomaterials,2011, 32 ,469-477。（IF：7.365）
3. Ang Li, Lili Qin, Di Zhu, Rongrong Zhu, Jing Sun，Shilong Wang*, Signalling pathways involved in the activation of dendritic cells by layered double hydroxide nanoparticles Biomaterials, 2010，31 ，748–756 （IF：7.365）
4. Jiao Wang, Rongrong Zhu, Dongmei Sun, Xiaoyu Sun, Zhengsong Geng, Hui Liu, Shi-Long Wang* Intracellular Uptake of Curcumin-Loaded Solid Lipid Nanoparticles Exhibit Anti-inflammatory  Activities Superior to Those of Curcumin through the NF-B Signaling Pathway, J. Biomed.Nanotechnol. 2015, Vol. 11, 403–415.     (If: 7.578)
5. Bin Luo, Shuai Xu, An Luo, Wen-Rui Wang, Shi-Long Wang, Jia Guo, Yao Lin, Dong-Yuan Zhao, and Chang-Chun Wang,  Mesoporous Biocompatible and Acid-Degradable Magnetic Colloidal Nanocrystal Clusters with Sustainable Stability and High Hydrophobic Drug Loading Capacity, ACS NANO, 2011, 5 (2), 1428–1435. （IF：7.493）
6. Dian Li , Jing Tang , Chuan Wei , Jia Guo , Shilong Wang , Deeptangshu Chaudhary , and Changchun Wang ，Doxorubicin-Conjugated Mesoporous Magnetic Colloidal Nanocrystal Clusters Stabilized by Polysaccharide as a Smart Anticancer Drug Vehicle，Small ， 2012, 8, No. 17, 2690–2697 ( If: 7.514)
7. Wan-Fu Ma, Ke-Yi Wu, Jing Tang, Dian Li, Chuan Wei, Jia Guo, Shi-Long Wang and Chang-Chun Wang，Magnetic drug carrier with a smart pH-responsive polymer network shell for controlled delivery of doxorubicin ，Journal of Materials Chemistry，2012, 22, 15206。(If: 6.626)
8. Li, Dian; Tang, Jing; Guo, Jia; Wang, Shilong; Chaudhary, Deeptangshu; *Wang, Changchun， Hollow-Core Magnetic Colloidal Nanocrystal Clusters with Ligand-Exchanged Surface Modification as Delivery Vehicles for Targeted and Stimuli-Responsive Drug Release ，CHEMISTRY-A EUROPEAN JOURNAL, 2012，18(51), 16517-16524  (If: 5.696)
9. Cui-Yuan Yu, Bin-Cheng Yin*, Shilong Wang, Zengguang Xu, and Bang-Ce Ye*, Improved Ligation-Mediated PCR Method Coupled with T7 RNA Polymerase for Sensitive DNA Detection, Analytical Chemistry, 2014, 86, 7214−7218,  (If: 5.825)
10. Bin Luo, Shuai Xu, Wan-Fu Ma, Wen-Rui Wang, , Shi-Long Wang, Jia Guo, Wu-Li Yang, Jian-Hua Hu and Chang-Chun Wang*  Fabrication of magnetite hollow porous nanocrystal shells as a drug carrier for paclitaxel，Journal of Materials Chemistry 2010, 20, 7107–7113（IF：5.098 ）
11. Mei Wang，Liming Cheng*，Quanbao Li，Zhiwen Chen， Shilong Wang*，Two-dimensional nanosheets associated with one-dimensional single-crystalline nanorods self-assembled into three-dimensional flower-like Mn3O4 hierarchical architectures，Phys. Chem. Chem. Phys., 2014, 16, 21742—21746  (If: 4.198)
12. Qingxiu Wang, Xianzheng Wu, Lijun Wang, Zhiwen Chen, Shilong Wang* Graphene/SnO2 Nanocomposites Decorated with Quantum Tunneling Junctions: Preparation Strategies, Microstructures and Formation Mechanism，Phys. Chem. Chem. Phys，2014，16, 19351-19357  (If: 4.198)
13. Jiao Wang, Rongrong Zhu, Xiaoyu Sun, Yanjing Zhu, Hui Liu, Shi-long Wang* Intracellular uptake of etoposide-loaded solid lipid nanoparticles induces an enhancing inhibitory effect on gastric cancer through mitochondria-mediated apoptosis pathway. Int J Nanimedicine. 2014:9 3987–3998.  (If: 4.195)
14. Wen-yu Qian, Dong-mei Sun, Rong-rong Zhu, Xi-ling Du, Hui Liu, Shi-long Wang , pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release, Int J Nanimedicine. 2012:7  5781–5792         (If: 4.195)
15. Wenrui Wang, Rongrong Zhu, Qian Xie, Ang Li, Yu Xiao, Kun Li, Hui Liu, Daxiang Cui, Yihan Chen, Shilong Wang. Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in Solid lipid nanoparticles. Int J Nanimedicine.. 2012:7 3667–3677  (If: 4.195)
16. Lili Qin，Mei Wang，Rongrong Zhu，Songhui You,Ping Zhou,Shilong Wang*，The in vitro sustained release profile and antitumor effect of etoposide-layered double hydroxide nanohybrids，Int J Nanimedicine.，2013:8 2053–2064，(If: 4.195)
17. Yan Tian*, Xiu Shi, Chunqiang Lu, Xiting Wang,  Shilong Wang*, Charge Separation in solid-State Nanopartilces-Sensitized Photovoltaic Cell, Electrochemostry Communications，2009,11，1603-1605     (If: 4.194)
18. Zhen Xu, Shi-Long Wang, Hong-Wen Gao, Effects of Nanosized Silicon Dioxide on the Structures and Activities of Three Functional Proteins, Journal of Hazardous Materials, 2010.180, 375-383 （IF：4.144）
19. R R Zhu, L L Qin, M Wang, S M Wu, S L Wang, R Zhang, Z X Liu, X Y Sun, S D Yao. Preparation, Characterization and anti-tumor property of Podophyllotoxin-loaded Solid Lipid Nanoparticles. Nanotechnology, 2009，Vol,20,No.5. Published online.(http://stacks.iop.org/0957-4484/20/055702)（IF：3.446）
20. Lili Qin  , Meng Xue, Wenrui Wang, Rongrong Zhu,Shilong Wang*,Jing Sun, Rui Zhang, Xiaoyu Sun.The in vitro and in vivo anti-tumor effect of Layered Double Hydroxides nanoparticles as delivery for Podophyllotoxin，International Journal of Pharmaceutics，2010, 388，223–230（IF：3.061）

Honors & Recognition: 
1.2007 years of Shanghai Yucai award.
2. take undergraduate courses "protein chemistry", in 2006 was named the Tongji University courses and Shanghai key course construction
3. guidance of graduation thesis in 2007 was recommended as the Tongji University for outstanding undergraduate thesis
4. guide students to take part in the 2007 tenth national "Challenge Cup" competition, "the works of high temperature and high alcohol producing yeast strain optimization" won the two prize in Shanghai city.

Postdoc, PhD and master candidate positions