Education & Training:
1991-1995, Jilin University, Bachelor degree;
1995-2000, Institute of Biophysics, CAS, Ph.D. degree.
2000-2003, postdoctoral fellow, Institute of biochemistry and cell biology, CAS, Shanghai, China;
2003-2006, postdoctoral fellow, Laboratoire d’Enzymologie et Biochimie Structurales (LEBS), CNRS, France;
2006-present, Professor, Institute of protein research, Tongji University, Shanghai, China.
Research Interests: Protein structure and function
Research Description:
Dr. Wang’s lab is interested in protein research in order to understand how proteins perform their various biological functions. Two major topics are:
1.Regulation of microtubule assembly. Microtubules, the hollow cylinder assembly of -tubulin heterodimers, are a major component of cytoskeleton and play essential roles in many physiological events, such as cell polarity, protein and organelle transport, cell motility, and cell division. Microtubules are highly dynamic, their assembly and disassembly are delicately regulated both spatially and temporally to meet different cellular needs. Kinesin-13 (KinI kinesins) is a newly identified protein family which shares a conserved motor domain with other conventional kinesins but utilizes the ATP hydrolysis energy to actively depolymerize microtubules. We are trying to understand the mechanism of microtubule depolymerization by KinI kinesins, which will also facilitate the understanding of the interaction between cytoskeleton and motor proteins.
2.Peptide neurotoxins from poisonous animals. The current toxin work is focused on the structural and functional study of conotoxins, the peptide neurotoxins produced by predatory marine gastropod cone snails. As a powerful weapon used by cone snails to prey and defense, conotoxins have high specificity and potency. Conotoxins are mainly disulfide-rich peptides and exhibit surprisingly high diversity of sequence, structure and activity. The research work includes the purification and characterization of conotoxins from cone snails in South China Sea, which not only elucidate the structure and function of these toxins, but also pave the way for the potential application.
Representative Publication (less than 20 papers)：
1.Aiping Lu, Longjin Yang, Shaoqiong Xu, and Chunguang Wang*. Various conotoxin diversifications revealed by a venomic study of Conus flavidus. Mol. Cell Proteomics, 2014, 13(1): 105-118.
2.Wentao Peng, Zhijie Lin, Weirong Li, Jing Lu, Yueyuan Shen*, Chunguang Wang*. Structural insights into the unusually strong ATPase activity of the AAA domain of the Caenorhabditis elegans fidgetin-like 1 (FIGL-1) protein. J. Biol. Chem. 2013 288: 29305-29312.
3.Benoît Gigant, Weiyi Wang, Birgit Dreier, Qiyang Jiang, Ludovic Pecqueur, Andreas Plückthun, Chunguang Wang*, Marcel Knossow*. Structure of a kinesin–tubulin complex and implications for kinesin motility. Nat. Struct. Mol. Biol. 2013, 20(8): 1001-1007.
4.Maorong Wen, Chunguang Wang*. The nucleotide cycle of spastin correlates with its microtubule-binding properties. FEBS J. 2013, 280: 3868-3877.
5.Shaoqiong Xu, Hua Li, Xiaoxia Shao, Chongxu Fan, Bryan Ericksen, Jinsong Liu, Chengwu Chi*, Chunguang Wang*. Critical Effect of Peptide Cyclization on the Potency of Peptide Inhibitors against Dengue Virus NS2B-NS3 Protease. J. Med. Chem. 2012, 55(15): 6881-6887.
6.Ludovic Pecqueur, Christian Duellberg, Birgit Dreier, Qiyang Jiang, Chunguang Wang, Andreas Pluckthun, Thomas Surrey, Benoit Gigant, Marcel Knossow*. A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end. Proc Natl Acad Sci U S A 2012, 109(30): 12011-12016.
7.Weiyi Wang, Qiyang Jiang, Manuela Argentini, David Cornu, Benoît Gigant, Marcel Knossow*, Chunguang Wang*. Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization. J. Biol. Chem. 2012, 287(18): 15143-15153.
8.Mingyu Ye, Keith K. Khoo, Shaoqiong Xu, Mi Zhou, Nonlawat Boonyalai, Matthew A. Perugini, Xiaoxia Shao, Chengwu Chi, Charles A. Galea, Chunguang Wang*, and Raymond S. Norton*. Im23a, a helical conotoxin with a novel cysteine framework from Conus imperialis, defines a novel K-superfamily. J. Biol. Chem. 2012, 287(18): 14973-14983.
9.Yuhong Han, Feijuan Huang, Hui Jiang, Li Liu, Qi Wang, Yanfang Wang, Xiaoxia Shao, Chengwu Chi, Weihong Du and Chunguang Wang*. Purification and structural characterization of a d-amino acid-containing conopeptide, conomarphin, from Conus marmoreus. FEBS J. 2008, 275: 1976-1987.
10.Chuanguang Wang, Anthony Cormier, Benoit Gigant, Marcel Knossow. Insight into the GTPase activity of tubulin from complexes with stathmin-like domains. Biochemistry, 2007, 46: 10595-10602.
11.Benoît Gigant, Chunguang Wang, Raimond B. G. Ravelli, Fanny Roussi, Michel O. Steinmetz, Patrick A. Curmi, André Sobel, Marcel Knossow. Structural basis for the regulation of tubulin by vinblastine. Nature 2005, 435(7041): 519-522.
12.Chunguang Wang, Nicolas Gilles, Alain Hamon, Frédéric Le Gall, Maria Stankiewicz, Marcel Pelhate, Yumei Xiong, Dacheng Wang, Chengwu Chi. Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis. Biochemistry 2003, 42(16): 4699-4708.
13.Chunguang Wang, Xiaolin He, Feng Shao, Wei Liu, Minhua Ling, Dacheng Wang, Chengwu Chi. Molecular characterization of an anti-epilepsy peptide from the scorpion Buthus martensi Karsch. European Journal of Biochemistry 2001, 268(8): 2480-2485.
Honors & Recognition:
2005年获上海市科技进步一等奖；
2006年入选上海市“曙光学者”；
2007年获上海市“浦江人才”资助；
2008年入选同济大学优秀青年教师；
2009年入选教育部“新世纪优秀人才”；
2011年获同济大学十大“我心目中的好导师”称号。
