MD, Ph.D, Professor
School of Life Sciences and Technology, Tongji University
Email : yaozu.xiang@tongji.edu.cn
Address : School of Life Sciences and Technology, Tongji University
Education
2012-2015 Postdoc Fellow, Advisor: Prof. John Hwa
Yale University, New Haven, USA
2008- 2012 Ph.D., Molecular Hematology, Advisor: Prof. David A Lane
Imperial College London, London, UK
2005- 2008 MSc, Internal Medicine, Advisors: Prof. Boli Zhang
Tianjin University of TCM, Tianjin, China
2000- 2005 MD, BSc., Clinical Medicine
Tianjin University of TCM, Tianjin, China
Publications
1.Fu L, Xie C, Jin Z, Tu Z, Han L, Jin M, Xiang Y, Zhang A. The prokaryotic Argonaute proteins enhance homologous sequence-guided gene editing in bacteria. Nucleic Acids Research. 2019 Jan.
2.Wang D, Hu X, Lee SH, Chen F, Jiang K, Tu Z, Liu Z, Du J, Wang L, Yin C, Liao Y, Shang H, Martin KA, Herzog RI, Young LH, Qian L, Hwa J, Xiang Y. Diabetes Exacerbates Myocardial Ischemia/Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation. JACC Basic Transl Sci. 2018;3(3):350-362.
3.Zou S, Teixeira AM, Yin M, Xiang Y, Xavier-Ferrucio J, Zhang PX, Hwa J, Min W, Krause DS. Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation. Thromb Haemost. 2016;116(3):506-16.
4.Lee SH, Du J, Stitham J, Atteya G, Lee S, Xiang Y, Wang D, Jin Y, Leslie KL, Spollett G, Srivastava A, Mannam P, Ostriker A, Martin KA, Tang WH, Hwa J. Inducing mitophagy in diabetic platelets protects against severe oxidative stress. EMBO Mol Med. 2016;8(7):779-95.
5.Xiang Y, Hwa J. Regulation of VWF expression, and secretion in health and disease. Curr Opin Hematol. 2016;23(3):288-93.
6.Xiang Y, Cheng J, Wang D, Hu X, Xie Y, Stitham J, Atteya G, Du J, Tang WH, Lee SH, Leslie K, Spollett G, Liu Z, Herzog E, Herzog RI, Lu J, Martin KA, Hwa J. Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor. Blood. 2015;125(22):3377-87.
7.Crawley JT, de Groot R, Xiang Y, Luken BM, Lane DA. Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor. Blood. 2011;118(12):3212-21.
8.Xiang Y, de Groot R, Crawley JT, Lane DA. Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13). PNAS. 2011;108(28):11602-7.
9.Xiang YZ. Adrenoreceptors, platelet reactivity and clopidogrel resistance. Thromb Haemost. 2008 Nov;100(5):729-30.
10.Xiang YZ, Xia Y, Gao XM, Shang HC, Kang LY, Zhang BL. Platelet activation, and antiplatelet targets and agents: current and novel strategies. Drugs. 2008;68(12):1647-64.
11.Xiang YZ, Kang LY, Gao XM, Shang HC, Zhang JH, Zhang BL. Strategies for antiplatelet targets and agents. Thromb Res. 2008;123(1):35-49.
12.Xiang YZ, Shang HC, Gao XM, Zhang BL. A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials. Phytother Res. 2008;22(7):851-8.
