Education & Training:
B.S., Tongji University, 1998-2002
Ph.D., Tongji University, 2002-2007
Postdoctoral Associate, Stony Brook University, 2009-2010

Research Interests:
1, nano drug carrier systems (LDH-Cur, SLN-Cur, LDH-VP16) for targeted cancer therapy
2. nano materials as a carrier for the treatment of neurodegenerative diseases
3, the function of nano material on stem cell differentiation

Research Description:
1 Biological effects of nano-sized materials, such as SiO2, LDH and SLN.  
2 Nano carriers for cancer treatment and other diseases
3 Nanoparticles used for the treatment of depression and Parkinson

Key Word: lung cancer, nano carrier, neurodegenerative diseases, stem cell differentiation

Representative Publication (less than 20 papers)：

1. Zhu R, Cheng KW, Mackenzie G, Huang L, Sun Y, Xie G, Vrankova K, Constantinides PP, Rigas B. 2012, Phospho-Sulindac (OXT-328) Inhibits the Growth of Human Lung Cancer Xenografts in Mice: Enhanced Efficacy and Mitochondria Targeting by its Formulation in Solid Lipid Nanoparticles. Pharmaceutical research, 29(11):3090-101（impact factor: 4.742）
2. Wang J, Zhu R, Gao B, Wu B, Li K, Sun X, Liu H, Wang S.The enhanced immune response of hepatitis B virus DNA vaccine using SiO2@LDH nanoparticles as an adjuvant. Biomaterials 35 (2014) 466-478 (impact factor: 7.604)
3. Wang W, Zhu R(并列第一）, Xie Q, Li A, Xiao Y, Li K, Liu H, Cui D, Chen Y, Wang S. 2012， Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles. International journal of nanomedicine, 7:3667-77. (impact factor: 3.463)
4. Zhu R, Wu X, Xiao Y, Gao B, Xie Q, Liu H, Wang S. (2013) Synergetic effect of SLN-curcumin and LDH-5-Fu on SMMC-7721 liver cancer cell line. Cancer Biotherapy & Radiopharmaceuticals . 28(8):579-87 (impact factor: 1.7)
5. Zhu R, Zhu Y, Zhang M, Xiao Y, Du X, Liu H, Wang S. The induction of maturation on dendritic cells by TiO2 and Fe3O4@TiO2 nanoparticles via NF-κB signaling pathway.Mater Sci Eng C Mater Biol Appl. 2014 ; 39:305-14. (impact factor: 2.468)
6. Zhang M, Zhu R(并列第一), Zhang M, Gao B, Sun D, Wang S. 2012 Nov 6, High-energy pulse-electron-beam-induced molecular and cellular damage in Saccharomyces cerevisiae. Res Microbiol, pii: S0923-2508(12)00168-4.
7. Zhang M, Xiao Y, Zhu R, Zhang Q, Wang SL. Enhanced thermotolerance and ethanol tolerance in Saccharomyces cerevisiae mutated by high-energy pulse electron beam and protoplast fusion. 2012 Nov; Bioprocess Biosyst Eng. 35(9):1455-65.
8. Wang M, Qin L, Li K, Zhu R, Wang W, Wang S. 2012, The Improvement of the Anticancer Effect of a Novel Compound Benzoic Acid, 2-Hydroxy-, 2-D-ribofuranosylhydrazide (BHR) Loaded in Solid Lipid Nanoparticles.AAPS PharmSciTech. 13(4):1348-54
9. Ang Lia, Lili Qina, Wenrui Wanga, Rongrong Zhua, Yongchun Yua, Hui Liub, Shi-Long Wanga*， The use of layered double hydroxides as DNA vaccine delivery vector for enhancement of anti-melanoma immune response, Biomaterials 32 (2011) 469-477。（IF：7.365）
10. Wenrui Wang, Rongrong Zhu, Rong Xiao, Hui Liu, Shi-Long Wang*，The electrostatic interactions between nano-TiO2 and trypsin inhibit the enzyme activity and change the secondary structure of trypsin,Trace Elem Res. DOI 10.1007/s12011-010-8823-x （IF：1.1）
11. Rong-Rong Zhu a, Wen-Rui Wang a, Xiao-Yu Sun a, Hui Liu b,*, Shi-Long Wang a,** Enzyme activity inhibition and secondary structure disruption of nano-TiO2 on pepsin，Toxicology in Vitro，2010 ，24 ，1639–1647，（IF：2.06）
12. Lili Qin# a , Meng Xue# a, Wenrui Wang a, Rongrong Zhu a, Shilong Wang* a,Jing Sun b, Rui Zhang c, Xiaoyu Sun a The in vitro and in vivo anti-tumor effect of Layered Double Hydroxides nanoparticles as delivery for Podophyllotoxin，International Journal of Pharmaceutics，2010 ，388， 223–230（IF：3.061）
13. Ang Li, Lili Qin, Di Zhu, Rongrong Zhu, Jing Sun，Shilong Wang*, Signalling pathways involved in the activation of dendritic cells by layered double hydroxide nanoparticles,, Biomaterials, 2010，31 ，748–756 （IF：7.365）
14. R R Zhu, L L Qin, M Wang, S M Wu, S L Wang, R Zhang, Z X Liu, X Y Sun, S D Yao. Preparation, Characterization and anti-tumor property of Podophyllotoxin-loaded Solid Lipid Nanoparticles. Nanotechnology, 2009，Vol,20,No.5. （IF：3.946）
15. Ling-Li Cheng, Mei Wang, Hui Zhu, Kun Li, Rong-Rong Zhu, Xiao-Yu Sun, Si-De Yao, Qing-Sheng Wu, Shi-Long Wang* ，Characterization of the transient species generated by the photoionization of Berberine: a laser flash photolysis study，Spectrochimica Acta Part A:2009，73，955-959。（IF：1.511）
16. Lingli Cheng, Mei Wang, Ping Zhao，Hui Zhu, Rongrong Zhu, Xiaoyu Sun, Side Yao, Shilong Wang* The examination of berberine excited state by laser flash photolysis，Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy，2009，73，268-272。（IF：1.511）
17. Rong R. ZHU, Shi L. WANG, Jun Chao, Dong lu Shi, Rui Zhang, Xiao Y. SUN，Si D. YAO. Bio-effects of Nano-TiO2 on DNA and cellular ultrastructure with different polymorph and size. Materials Science and Engineering C.，2009, Vol . 29, 691-696 （IF：1.812）
18. Rongrong Zhu，Jun Chao，Shilong Wang，Xiaoyu Sun，Side Yao. Oxidative and binding effect of Nano-TiO2 on Plasmid DNA and Pepsin. 2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008, 1013-1016
19. Shiqiang Li, Rongrong Zhu, Hong Zhu, Meng Xue, Xiaoyu Sun, Side Yao, Shilong Wang *，Nanotoxicity of TiO2 nanoparticles to erythrocyte in vitro，Food and Chemical Toxicology，2008，46， 3626-3631。
20. Lili Qin, Shilong Wang*, Rui Zhang, Rongrong Zhu, Xiaoyu Sun, Side Yao ，Two different approaches to synthesizing Mg-Al-layered double hydroxides as folic acid carriers，Journal of Physics and Chemistry of Solids，2008，69，2779-2784。
21. Li Shiqiang, Zhu Hong, Zhu Rongrong Sun Xiaoyu Yao Side Wang Shilong*, Impact and mechanism if TiO2 nanoparticles on DNA synthesis in vitro, Science in China B: chemisty.2008, 51(4):367-372。

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Honors & Recognition: 
Dawn of the Shanghai scholar;
Shanghai excellent young teacher

One master candidate position