Education & Training:
B.S., Sontheast University, 1990.
M.S., Tongji University, 1996.
Ph.D., the Second Military Medical University ,2006.
Research Interests:
This laboratory is interested in two areas:
（1）The regulatory mechanism of non-coding RNAs in stem cell differentiation;
(2) Molecular and cellular mechanisms of nickel‐induced Carcinogenesis.
Research Description:
(1)Using bioinformatics, ChIP, 5’RACE, EMSA approaches to investigate the interaction among miR-592, NF-κB and lnRNA, and to reveal the positive and negative regulatory loop among them, and its mechanism in NSC differentiation.
(2)Establishing animal model and nickel-transformed cell line and using molecular cell biology, biochemistry, genetics and other approaches to explore the alterations of genes, miRNAs, methylation and DNA damage in nickel carcinogenesis.
Key Word: miR-592; NPCs; differentiation; epigenetics; nickel; Carcinogenesis.
Representative Publication (less than 20 papers)：
1.Jun Zhang，Jing Zhang* , Yang Zhou，You-jun Wu,，Lin Ma, Rui-jin Wang ,Sun-quan Huang ,Rong-rong Gao, Li-hong Liu ,Zhi-hua Shao,Hong-jun Shi，Li-ming Cheng and Long Yu . Novel Cerebellum-enriched miR-592 may play a role in Neural Progenitor Cell Differentiation and Neuronal Maturation through Regulating Lrrc4c and Nfasc in Rat.. Curr Mol Med. 2013，13（9） 1432-45 (* co-first author).
2.Jing Zhang，Yang Zhou，You-Jun Wu, Meng-Jie Li，Rui-Jin Wang,Shun-Quan Huang, Rong-Rong Gao, Lin Ma, Hong-Jun Shi， Jun Zhang. Hyper-methylated miR-203 dysregulates ABL1 and contributes to thenickel-induced tumorigenesis. Toxicol Lett . 2013，223（1)： 42–51
3.Jing Zhang, Yang Zhou, Lin Ma, Shunquan Huang, Ruijin Wang ,Rongrong Gao, Youjun Wu,Hongjun Shi,Jun Zhang. The Alteration of MiR-222 and Its Target Genes in Nickel-Induced Tumor. Biol Trace Elem Res 2013，152（2）：267-274.
4.Jing Zhang , Yang Zhou,Youjun Wu ,Lin Ma ,Yingying Fan ,Xuan Kang , Hongjun Shi , Jun Zhang*.Isolation and Characterization of a Novel Noncoding RNA from Nickel-Induced Lung Cancer. Biol Trace Elem Res .2012,150（1-3）：258-263
5 . Jing Zhang ， Jun Zhang , Yingying Fan , Mengjie Li , Yang Zhou ，Zhihua Shao ， Hong-jun Shi ，Ying Wang. Identification of differentially expressed genes in lung of nickel-exposed rats . Biol Trace Elem Res，2011,143(2)：1007-1017.
6. Jun Zhang ，Jing Zhang* , Li-hong Liu, Yang Zhou ，You-jun Wu, Yi-ping Li , Zhi-hua Shao , Meng-jiLi, Ying-ying Fan, and Hong-jun Shi. Effects of miR-541 on neurite outgrowth during neuronal differentiation .Cell Biochem Funct. 2011; 29（4）：279-286. (* co-first author).
7. ZHANG Jun, ZHANG Jing*, LI MengJie, Wu YouJun, FAN YingYing, ZHOU Yang, TAN LiLi, SHAO ZhiHua, SHI HongJun . Methylation of RARβ2, RASSF1A and CDKN2A Genes Induced by Nickel Subsulfide and Nickel-carcinogenesis in Rats. Biomed Environ Sci，2011，24（2）：163-171 . (* co-first author).
8. Jing Zhang， Jun Zhang , Youjun Wu, Yang Zhou，Zhihua Shao ，Xuan Kang, Lin Ma, Mengjie Li, Lihong Liu, and Hongjun Shi. Sez-6 May Play an Important Role in Neurite Outgrowth through the PKC Signaling Pathways.Z NATURFORSCH C. 2011，66（11-12）：614-620
