Education & Training:
B.S., Xiangya Medical college,Zhongnang University, 1997
Ph.D., Tongji University, 2007
Postdoctoral Associate, University of Minnesota/ East Tennessee State University, 2009-2011
Research Interests:
1. To understand the epigenetic regulatory mechanisms that govern cell fate decisions in both stem cell differentiation and reprogramming
2. To identify new epigenetic modifying factors involved in liver cancer, prostate cancer by using the combination of conventional methods and high-throughput technologies
3. evidence-based medicine
Research Description:
Epigenetic regulation is mediated by various mechanisms mainly including histone modifications, DNA methylation and non-coding RNAs. Stable epigenetic states are essential for the maintenance of tissue and cell type specific functions. Disruption of epigenetic balance often leads to cancer or other diseases, and also perturbs the states of stem cells. How these epigenetic signals play their fate-directing roles in carcinogenesis and in stem cell differentiation remain to be understood.
Our ultimate goal is to understand the dynamic regulation of chromatin in stem cell and cancer biology, which would provide basic theories and further benefit stem cell and cancer therapeutic applications by identifying novel prognostic markers and epigenetic targets.
Key Word: Epigenetics, stem cell, differentiation, cancer
Representative Publication (less than 20 papers)：
1. Fan Y*, Chen P*, Li Y,Zhu MY. Effects of chronic social defeat on expression of dopamine β-hydroxylase in rat brains. Synapse. 2013 Jun;67(6):300-12 .
2.Chen P,Fan Y, Li Y, Sun Z, Bissette G, Zhu MY. Chronic social defeat up-regulates expression of norepinephrine transporter in rat brains. Neurochem Int. 2012 Jan;60(1):9-20
3.Joe Wu, P Chen, C Ardell and G Wright .HIF-1α and cardioprotection. TENNESSEE PHYSIOLOGICAL SOCIETY MEETING 2011.10
4. Chen P, Fan Y, Li Y, Zhu MY. Chronic social defeat up-regulates the expression of norepinephrine transporter and dopamine β-hydroxylase in rat brains. Society for neuroscience 40th annual meeting in San diego, USA. 2010.11
5.Chen P,Li A,Zhang MJ,He ML, Wang Sl, Liang LP. Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells. Acta Biochimica et Biophysica Sinica. 2008,40(2):125-132
6. Chen P, Liang LP,et al. catalytic metalloporphyrin protects against MPTP-induced Parkinson’s disease in mice.Academic Journal of Second Military Medical University. 2008,29(1):36-41
7.Chen P, Li A, Wang Sl, Liang LP, et al. A Catalytic Metalloporphyrin Protects against Paraquat Neurotoxicity in vivo[J]. Biomedical and Environmental Sciences,2008,21(3):233-238
8. Li A, He M, Wang H, Qiao B, Chen P, Gu H, Zhang M, He S.All-trans retinoic acid negatively regulates cytotoxic activities of nature killer cell line 92. Biochem Biophys Res Commun. 2007 Jan 5;352(1):42-7. Epub 2006 Nov 2
