Deqiang Ding

Contact Info

Telephone: 86-19121743756         

Email: dingdeqiang@tongji.edu.cn

Address: School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Yangpu District, Shanghai, 200092, P.R.China

General Info

Research Experience

Jan. 2020- present             Professor & Principal Investigator

                                          Shanghai First Maternity and Infant Hospital

                                          Tongji University, Shanghai, China

Dec. 2019- present            Professor & Principal Investigator

                                          School of Life Sciences and Technology

                                          Tongji University, Shanghai, China

Sept. 2014- Dec. 2019       Postdoctoral Fellow  

                                   Advisor: Prof. Chen Chen

                                           Michigan State University, USA

Education

Sept. 2009- July 2014        Ph.Din Cell Biology

Advisor: Prof. Yu-sheng Cong

Beijing Normal University, Beijing, China

Sept. 2005- July 2009        B.S. in Life Science

Qingdao University, Qingdao, China

Research Interests

My research focuses on the molecular mechanisms underlying mammalian spermatogenesis and infertility using molecular, cellular, biochemical, mouse genetics and genomics approaches. My current works focus on piRNA biogenesis in mouse germ cells, the function of piRNA and piRNA pathway associated proteins in gene silencing, genome stability and epigenetics during male germ cell development.

Research Publications

https://scholar.google.com/citations?user=LaBFitsAAAAJ&hl

1.      Ding, D.#, Wei, C., Dong, K., Liu, J., Stanton, A., Xu, C., Min, J., Hu, J., and Chen, C#. (2020). LOTUS domain is a novel class of G-rich and G-quadruplex RNA binding domain. Nucleic acids research, doi: 10.1093/nar/gkaa652. (Correspondence)

2.      Ding, D., and Chen, C. (2020). Zucchini: the key ingredient to unveil piRNA precursor processing. Biology of reproduction, doi:10.1093/biolre/ioaa090

3.      Ding, D.*, Liu, J.*, Dong, K., Melnick, A., Latham, K.E., and Chen, C. (2019). Mitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis. Nucleic acids research 47, 2594-2608.

4.      Ding, D., Liu, J., Midic, U., Wu, Y., Dong, K., Melnick, A., Latham, K.E., and Chen, C. (2018). TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice. Nature communications 9, 127.

5.      Ding, D.*, Liu, J.*, Dong, K.*, Midic, U., Hess, R.A., Xie, H., Demireva, E.Y., and Chen, C. (2017). PNLDC1 is essential for piRNA 3' end trimming and transposon silencing during spermatogenesis in mice. Nature communications 8, 819.

6.      Liu, N.*, Ding, D.*, Hao, W., Yang, F., Wu, X., Wang, M., Xu, X., Ju, Z., Liu, J.P., Song, Z., et al. (2016). hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor. Nucleic acids research 44, 8693-8703.

7.      Melnick, A., Gao, Y., Liu, J., Ding, D., Predom, A., Kelly, C., Hess, R., and Chen, C. (2019). RNF216 is essential for spermatogenesis and male fertility. Biology of reproduction https://doi.org/10.1093/biolre/ioz006

8.      Zhang, H.*, Liu, K.*, Izumi, N.*, Huang, H., Ding, D., Ni, Z., Sidhu, S.S., Chen, C., Tomari, Y., and Min, J. (2017). Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2. Proceedings of the National Academy of Sciences of the United States of America 114, 12483-12488.

Positions

Positions for postgraduates pursuing Master’s degree or PhD degree and for post-docs are available.