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(5月16日) Extracellular Signaling Regulation on Neoblast Repopulation
来源:  作者:  发表时间:2017-05-11  阅读次数:1389次

人:雷凯

人:高绍荣 教授

    间:5月16日上午10:00

    点:医学楼1101室

Research Focus

My research is focused on signaling mechanisms controlling in vivo stem cell repopulation. Planarians are free-living flatworms, capable of rapidly regenerating from any injury. This incredible ability relies on a proliferative population of cells called “neoblasts” that contain adult pluripotent stem cells. Remarkably, a single pluripotent stem cell surviving sublethal irradiation can repopulate the entire neoblast compartment and generate all types of differentiated cells in the animal’s body. The robust stem cell regulation and methodologies to effectively visualize neoblasts at whole animal resolution makes these organisms a powerful in vivo model system to achieve my research goal. I will take a multidisciplinary approach combining molecular biology, biochemistry, genetics, microscopy, and computational biology to uncover the signaling mechanisms conferring the in vivo neoblast repopulation in planarians and apply in mammals.

Employment and Education

Ø  2011.12-present  Postdoctoral Research Associate, Stowers Institute for Medical Research, USA

Ø  2006.9-2012.1     Ph.D. in Developmental Biology, Fudan University, China

Ø  2002.9-2006.7     B.S. in Biology, Wuhan University, China

Selected Publications

  • 1. Davies, E., Lei, K., Seidel, C., Kroesen, A., McKinney, S., Guo, L., Robb S., Ross, E., Gotting, K., Sánchez Alvarado, A. (2017) Embryonic origin of adult stem cells required for tissue homeostasis and regeneration. eLife 6
  • 2. Lei, K., Vu H., Mohan R., McKinney S., Seidel C., Alexander R., Gotting K., Workman J., Sánchez Alvarado A. (2016) Egf signaling directs neoblast repopulation by regulating asymmetric cell division in planarians. Developmental Cell 38, 413-429. († Co-corresponding authors)
  • 3. Lei, K., Zhu, X., Xu, R., Xu, T., Zhuang, Y., Han, M. (2012) Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. Current Biology 22, 1609-1615.
  • 4. Yu, J*, Lei, K.*, Zhou, M., Craft, C., Xu, G., Xu, T., Zhuang, Y., Xu, R., Han, M. (2011). KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum. Mol. Genet. 20, 1061-1073. (* Co-first authors)
  • 5. Zhang, X, Lei, K., Yuan, X., Wu, X., Zhuang, Y., Xu, T., Xu, R., Han, M. (2009). SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron 64, 173-187.
  • 6. Lei, K.*, Zhang, X.*, Ding, X., Guo, X., Chen, M., Zhu, B., Xu, T., Zhuang, Y., Xu, R., Han, M. (2009). SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc. Natl. Acad. Sci. U. S. A. 106, 10207–10212. (* Co-first authors)

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