报告人：Dr. Kristen Verhey
Professor of Cell and Development Biology,
University of Michigan Medical School, Ann Arbor, USA.
Dr. Kristen Verhey received her Ph.D. in Biological Chemistry from Harvard University in 1995. She then carried out postdoctoral research in Cell Biology at Harvard Medical School in the laboratory of Dr. Tom Rapoport. In 2002, she started her own laboratory in the Dept. of CDB at the University of Michigan Medical School and rose through the ranks to be named Associate Professor (with tenure) in 2008 and Professor in 2013.
Research in the Verhey lab is focused on the regulations of microtubule-based transportations in mammalian cells. Her work has uncovered general mechanisms of kinesin regulation by autoinhibition of motor activity, spatial regulation by post-translational modifications of microtubule tracks, and temporal regulation by cargo binding. Recently, her lab identified the importin/Ran/nucleoporin system as a critical regulator of ciliary entry of the kinesin-2 motor KIF17. This work revealed important molecular, structural and functional relationships between nuclear-cytoplasmic and ciliary-cytoplasmic trafficking in mammalian cells.
1.Dishinger JF, Kee HL, Jenkins PM, Fan S, Hurd TW, Hammond JW, Truong YNT, Margolis B, Martens JR, and Verhey KJ. (2010). Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-b2 and Ran-GTP. Nature Cell Biology 12: 703-710.
2.Fan S, Whiteman EL, Hurd TW, McIntyre JC, Dishinger JF, Liu CJ, Martens JR, Verhey KJ, Sajjan U, and Margolis BL. (2011). Induction of Ran GTP Drives Ciliogenesis. Molecular Biology of the Cell 22(23): 4539-4548.
3.Kee HL, Dishinger JF, Blasius TL, Liu CJ, Margolis B, and Verhey KJ. (2012). A size-exclusion barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia. Nature Cell Biology 14(4): 431-437.
4.Takao D, Dishinger JF, Kee HL, Pinskey JM, Allen BL, and Verhey KJ. (2014). An assay for clogging the ciliary pore comples distinguishes mechanisms of cytosolic and membrane protein entry. Current Biology. 24(19): 2288-2294.
5.Engelke MF, Winding M, Yue Y, Shastry S, Teloni F, Reddy S, Blasius TL, Soppina P, Hancock WO, Gelfand VI, Verhey KJ. (2016). Engineered kinesin motor proteins amenable to small-molecule inhibition. Nature Communications 7:11159.