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李翀
来源:  作者:  发表时间:2017-04-26  阅读次数:1273次

     姓 名:李翀

     学位:博士

研究领域:发育生物学,生殖生物学

研究方向:1.体细胞核移植胚胎发育的表观遗传修饰缺陷机制研究。 

                      2.利用小分子化合物对克隆胚胎进行人为调控,改善克隆动物出生率的研究。 
                      3.哺乳类动物生殖细胞的长期非冷冻状态保存法的开发。

E-maillichong@tongji.edu.cn

联系电话:021-65987363

通讯地址:上海市四平路1239号同济大学生命科学与技术学院

 

个人简介:

        2001年毕业于上海师范大学生命科学与环境学院,获学士学位;2007年毕业于日本关西学院大学理工学研究科,获硕士学位;2010年毕业于日本关西学院大学理工学研究科,与日本理化学研究所(RIKEN)联合培养,获博士学位;2010年4月-2012年8月于日本理化学研究所,担任Research Scientist;2012年3月起于同济大学转化医学高等研究院,担任副研究员职务。期间,共发表SCI论文10余篇;主持国家自然科学基金“青年项目”一项;以主要成员身份参与科技部“国家重点研发计划干细胞及转化研究重点专项”一项。2009年获得国家优秀自费留学生奖学金;在国际学术会议中获奖多次。

 

发表论文

1.Liu X, Wang C, Liu W, Li J, Li C, Kou X, Chen J, Zhao Y, Gao H, Wang H, Zhang Y, Gao Y and Gao S. (2016) Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos. Nature 19362
2.Zhang B, Zheng H, Huang B, Li W, Xiang Y, Peng X, Ming J, Wu X, Zhang Y, Xu Q, Liu W, Kou X, Zhao Y, He W, Li C, Chen B, Li Y, Wang Q, Ma J, Yin Q, Kee K, Meng A, Gao S, Xu F, Na J, Xie W. (2016) Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature 19361
3.Xiang P, Wu KC, Zhu Y, Xiang L, Li C, Chen DL, Chen F, Xu G, Wang A, Li M, Jin ZB. (2014) A novel Bruch's membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells. Biomaterials.35:9777-88.
4.Terashita Y, Yamagata K, Tokoro M, Itoi F, Wakayama S, Li C, Sato E, Tanemura K, Wakayama T. (2013)Latrunculin A treatment prevents abnormal chromosome segregation for successful development of cloned embryos. PLoS One. 8:e78380.
5.Wakayama S, Kohda T, Obokata H, Tokoro M, Li C, Terashita Y, Mizutani E, Van Thuan N, Kishigami S, Ishino F, Wakayama T. (2013) Successful serial recloning in the mouse over multiple generations. Cell Stem Cell Cell Stem Cell. 12:293-7
6.Nagashimada M, Ohta H, Li C, Nakao K, Uesaka T, Brunet JF, Amiel J, Trochet D, Wakayama T, Enomoto H, (2012) Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression. J Clin Invest. 122:3145-58.
7.Terashita Y, Wakayama S, Yamagata K, Li C, Sato E, Wakayama T, (2012) Latrunculin A can improve the birth rate of cloned mice and simplify the nuclear transfer protocol by gently inhibiting actin polymerization. Biol Reprod. 86:180.
8.Yamagata K, Iwamoto D, Terashita Y, Li C, Wakayama S, Hayashi-Takanaka Y, Kimura H, Saeki K, Wakayama T. (2012) Fluorescence cell imaging and manipulation using conventional halogen lamp microscopy. PLoS One.7:e31638.
9.Li C, Wakayama T, (2012) Cloned mice from embryonic stem cells. Encyclopedia of molecular cell biology and molecular medicine.
10.Li C#, Mizutani E, Ono T, Terashita Y, Jia X-F, Shi H-J, Wakayama T, (2011) Mouse Spermatozoa Preserved for Six Months Without Freezing Can Develop to Full Term. Biol Reprod. 85:1183-90. (#Co-correspondence)
11.Terashita Y, Li C, Yamagata K, Sato E, Wakayama T. (2011) Effect of fluorescent mercury light irradiation on in vitro and in vivo development of mouse oocytes after parthenogenetic activation of sperm microinjection. J Reprod Dev. 57:564-71.
12.Ono T, Mizutani E, Li C, Yamagata K, Wakayama T. (2011) Offspring from intracytoplasmic sperm injection of aged mouse oocytes treated with caffeine of MG132. Genesis. 49:460-71.
13.Ono T, Li C, Mizutani E, Terashita Y, Yamagata K, Wakayama T. (2010) Inhibition of Class IIb Histone Deacetylase Significantly Improves Cloning Efficiency in Mice. Biol Reprod. 83:929-37.
14.Ono T, Mizutani E, Li C, Wakayama T. (2009) Preservation of sperm within the mouse cauda epididymidis in salt or sugars at room temperature. Zygote. 29:1-12.
15.Li C#, Mizutani E, Ono T, Wakayama T. (2009) An Efficient Method for Generating Transgenic Mice Using NaOH-treated Spermatozoa. Biol Reprod. 82:331-40. (#Co-correspondence)
16.Wakayama S, Kawahara Y, Li C, Yamagata K, Yuge L, Wakayama T.(2009)Detrimental Effects of Microgravity on Mouse Preimplantation Development In Vitro PLoS One. e6753.
17.Li C#, Mizutani E, Ono T, Wakayama T. (2009). Production of normal mice from spermatozoa denatured with high alkali treatment before ICSI. Reproduction 137:779-92. (#Co-correspondence)
18.Ono T, Mizutani E, Li C, Wakayama T. (2008) Nuclear Transfer Preserves the Nuclear Genome of Freeze-Dried Mouse Cells. J Reprod. Dev. 54:486-91. 
19.Mizutani E, Ono T, Li C, Maki-Suetsugu R, Wakayama T. (2008) Propagation of senescent mice using nuclear transfer embryonic stem cell lines. Genesis 46:478-83.
 

所获奖项:

1.Best Posters Award 首届核移植与细胞重编程国际研讨会 2016.3 日本 山梨
2.优秀论文奖  中国留日同学会第十三届留学成果报告会 2011.10  中国 南京
3.Best Posters Award   第九届国际转基因技术大会会议 2010.3  德国 柏林
4.2009年度国家优秀自费留学生奖学金  中华人民共和国教育部  2010.3 中国 北京
5.仁田纪念奖   日本关西学院大学 2010.1  日本 兵库
6.Award for Excellent Poster Presentation  第六届亚洲繁殖生物技术大会会议2009.11  柬埔寨 暹粒
7.Young Investigator’s Poster Award  理化学研究所神户研究所 CDB Retreat 2009.11 日本 兵库
8.Award for Excellent Poster Presentation  第五届亚洲繁殖生物技术大会会议 2008.11  中国 昆明

 

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