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魏珂
来源:  作者:  发表时间:2016-08-09  阅读次数:6927次

姓        名:魏珂

行政教务:教授

学         位:博士

导师情况:博士生导师

研究领域: 心脏发育与再生

研究方向:1、心脏再生的机理的研究
                    2、针对心肌细胞的增殖与成熟的高内涵药物筛选
                    3、药物在动物心脏损伤模型中的应用

E-mailkewei@tongji.edu.cn

联系电话: 17798238346

通讯地址: 上海市杨浦区四平路1239号,同济大学生命科学与技术学院,邮编200092

个人简介:

        2002年毕业于清华大学生物科学与技术系,获学士学位。2008年博士毕业于美国加利福尼亚大学洛杉矶分校,获理学博士学位,博士学习期间主要利用小鼠基因敲除模型进行心血管发育的研究。 2008年至2016年在美国桑福德伯纳姆普利贝司医学研究所(Sanford Burnham Prebys Medical Discovery Institute)从事心脏发育与再生的博士后研究。2016年入选同济大学基础学科高水平领航人才计划,任转化医学高等研究院特聘研究员。已在包括Nature等期刊发表SCI学术论文15篇。

研究领域(具体内容):
干细胞与再生生物学
心肌梗死疾病模型与转化医学
高内涵药物筛选

 

代表性论文:

  1. Ke Wei*, Vahid Serpooshan*, Cecilia Hurtado, Marta Diez-Cuñado, Mingming Zhao, Sonomi Maruyama, Wenhong Zhu, Giovanni Fajardo, Michela Noseda, Kazuto Nakamura, Xueying Tian, Qiaozhen Liu, Andrew Wang, Yuka Matsuura, Paul Bushway, Wenqing Cai, Alex Savchenko, Morteza Mahmoudi, Michael D. Schneider, Maurice J. B. van den Hoff, Manish J. Butte, Phillip C. Yang, Kenneth Walsh, Bin Zhou, Daniel Bernstein, Mark Mercola & Pilar Ruiz-Lozano “Epicardial FSTL1 Reconstitution Regenerates the Adult Mammalian Heart” (2015) Nature 525: 479-485 (* co-first author)
  2. Ke Wei*, Ramon Díaz-Trelles*, Qiaozhen Liu, Marta Diez-Cuñado, Maria-Cecilia Scimia,  Wenqing Cai, Junko Sawada, Masanobu Komatsu, Joseph J. Boyle, Bin Zhou, Pilar Ruiz-Lozano, and Mark Mercola “Developmental origin of age-related coronary artery disease” (2015) Cardiovascular Research 107 (2): 287-294 (* co-first author)
  3. Vahid Serpooshan, Morteza Mahmoudi, Mingming Zhao, Ke Wei, Senthilkumar Sivanesan, Khatereh Motamedchaboki, Andrey V. Malkovskiy, Andrew.B. Gladstone, Jeffrey Cohen, Phillip C. Yang, Jayakumar Rajadas, Daniel Bernstein, Y. Joseph Woo, Pilar Ruiz-Lozano “Protein corona influences cell-biomaterial interactions in nanostructured tissue engineering scaffolds.” (2015) Advanced Functional Materials 25 (28): 4379-4389
  4. Vahid Serpooshan, Mingming Zhao, Scott A Metzler, Ke Wei, Parisha B Shah, Andrew Wang, Morteza Mahmoudi, Andrey V Malkovskiy, Jayakumar Rajadas, Manish J Butte, Daniel Bernstein, Pilar Ruiz-Lozano (2014) “Use of bio-mimetic three-dimensional technology in therapeutics for heart disease” Bioengineered 5:3, 193-197
  5. Wenqing Cai, Sonia Albini, Ke Wei, Erik Willems, Rosa M Guzzo, Masanao Tsuda, Lorenzo Giordani, Sean Spiering, Leo Kurian, Gene W Yeo, Pier Lorenzo Puri, Mark Mercola (2013) “Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment” Genes & Development 27(21):2332-44
  6. Vahid Serpooshan, Mingming Zhao, Scott A Metzler, Ke Wei, Parisha B Shah, Andrew Wang, Morteza Mahmoudi, Andrey V Malkovskiy, Jayakumar Rajadas, Manish J Butte, Daniel Bernstein, Pilar Ruiz-Lozano (2013) “The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction” Biomaterials 34(36):9048-55
  7. Wenqing Cai, Rosa M. Guzzo, Ke Wei, Erik Willems, Herman Davidovics and Mark Mercola (2012) “A Nodal to TGFβ Cascade Exerts Biphasic Control Over Cardiopoiesis” Circulation Research 111: 876-881
  8. Maria Cecilia Scimia, Cecilia Hurtado, Saugata Ray, Scott Metzler, Ke Wei, Jianming Wang, Chris E. Woods, Nicole H. Purcell, Daniele Catalucci, Takeshi Akasaka, Orlando F. Bueno, George P. Vlasuk, Perla Kaliman, Rolf Bodmer, Layton H. Smith, Euan Ashley, Mark Mercola, Joan Heller Brown & Pilar Ruiz-Lozano (2012) “APJ acts as a dual receptor in cardiac hypertrophy”. Nature 488: 394–398
  9. Roberta Noberini, Sayantan Mitra, Ombretta Salvucci, Fatima Valencia, Srinivas Duggineni, Natalie Prigozhina, Ke Wei, Giovanna Tosato, Ziwei Huang, and Elena B. Pasquale (2011) “PEGylation Potentiates the Effectiveness of an Antagonistic Peptide That Targets the EphB4 Receptor with Nanomolar Affinity” Plos One 6(12): e28611
  10. Natalie L. Prigozhina, Andrew Heisel, Ke Wei, Roberta Noberini, Edward A. Hunter, Diego Calzolari, Jordan R. Seldeen, Elena B. Pasquale, Pilar Ruiz-Lozano, Mark Mercola and Jeffrey H. Price (2011) “Characterization of a novel angiogenic model based on stable, fluorescently labeled endothelial cell lines amenable to scale-up for high content screening” Biology of the Cell 103(10): 467-81
  11. Minqi Hao, Kevan Akrami, Ke Wei, Carlos De Diego, Nam Che, Jeong-Hee Ku, James Tidball, Michael C. Graves, Perry B. Shieh, Fabian Chen (2008) “Muscleblind-like 2 (Mbnl2) -deficient mice as a model for myotonic dystrophy” Developmental Dynamics 237(2): 403-10.
  12. Ke Wei, Jiyuan Chen, Kevan Akrami, Gary C. Galbraith, Ivan A. Lopez, and Fabian Chen (2007) “Neural Crest Cell Deficiency of c-myc Causes Skull and Hearing Defects” Genesis 45(6): 382-390
  13. Ke Wei, Jiyuan Chen, Kevan Akrami, and Fabian Chen (2007) “Generation of mice deficient for Lbx2, a gene expressed in the urogenital system, nervous system and Pax3 dependent tissues” Genesis 45(6): 361-368
  14. Ke Wei, Nam Che, and Fabian Chen. (2007). “Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression” Developmental Dynamics 236(2): 416-425.
  15. Xiao-Nan Dong, Ke Wei, Zu-Qiang Liu, and Ying-Hua Chen (2002). “Candidate peptide vaccine induced protection against classical swine fever virus” Vaccine 21(3-4): 167-173.

       课题组常年招聘博士后,研究助理;并欢迎博士生,硕士生,本科生报考和实习。

 

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