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龚国华
来源:  作者:  发表时间:2016-07-07  阅读次数:6192次

姓        名:龚国华

学        位:博士

导师情况:博士生导师

研究领域:线粒体与心血管疾病

研究方向

      1.线粒体功能评价
       2.iPS 细胞分化过程中线粒体发育和调控
       3.线粒体质量控制和疾病发生
       4.疾病中损伤线粒体功能的重塑

     E-mailguohgong@tongji.edu.cn

     联系电话:021-65982260

     通讯地址:上海市杨浦区四平路1239号,同济大学生命科学与技术学院,邮编200092

个人简介:

        2003毕业于西南大学,获农学学士学位。2010年博士毕业于四川大学,获理学博士学位,博士期间主要进行天然产物治疗心血管疾病的药理学和代谢研究。 2010年至2013年在美国华盛顿大学(University of Washington )医学院对可在体监测单个线粒体功能的 “超氧炫” 的发生机制和生理学意义进行研究。2013年至2015年在圣路易斯华盛顿大学(Washington University in St.Louis )医学院从事心肌线粒体发育和线粒体质量控制的博士后研究。2016年入选同济大学基础学科高水平领航人才计划。已在包括Science 和 Nature 等期刊发表发表SCI学术论文20余篇 ,获授权专利1项。。

代表论文:

1.Franco A, Kitsis R,Fleischer J, Gavathiotis E, Kornfeld O, Gong G, Biris N, Benz, Nir Qvit A, Donnelly S, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn G. (2016). Correcting Mitochondrial Fusion by Manipulating Mitofusin Conformations. Nature(Article) doi: 10.1038/nature20156. [Epub ahead of print].
2.Xu S, Wang P, Zhang H, Gong G, Gutierrez Cortes N, Zhu W, Yoon Y, Tian R, Wang W. (2016). CaMKII Induces Permeability Transition Through Drp1 Phosphorylation During Chronic β-AR Stimulation. Nature Communication 14(7)13189. doi: 10.1038/ncomms13189.
3.Wang W, Gong G, Wang X, Wei-LaPierre L, Chemg H, Dirksen R, Sheu S. (2016). Mitochondrial Flash: Integrative ROS and pH Signals in Cell and Organelle Biology. Antioxidants & Redox Signaling. 25 (9): 534-49.
4.Gong G, Song M, Csordas G, Kelly D, Matkovich S, Dorn G. (2015). Parkin-Mediated Mitophagy Directs Perinatal Cardiac Mitochondrial Metabolic Maturation In Mice. Science (Article). 350: aad2459. DOI: 10.1126/science. aad2459. (Highlighted by The Perspective of Science. 2015, 350: 1162-1163; the EDITORS’ CHLICE of Sci. Signal. 2015, 406: EC367)
5.Gong G, Liu X, Zhang H, Sheu S, Wang W. (2015). Mitochondrial Flash as A Novel Biomarker of Mitochondrial Respiration in The Heart. American Journal of Physiology Heart and Circulatory Physiology. 309 (7): H1166-H1177. (Featured article, Featured Podcast)     
6.Song M, Gong G, Burelle Y, Gustafsson A, Kitsis R, Matkovich S, Dorn G. (2015). Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circulation Research. 117 (4): 346-351. (Featured article)
7.Song M, Chen Y, Gong G, Murphy E, Rabinovitch  P, Dorn G. (2014). Super-Suppression of Mitochondrial Reactive Oxygen Species Signaling Impairs Compensatory Autophagy in Primary Mitophagic Cardiomyopathy. Circulation Research. 115 (3):348-53. (Featured article, 2014 Circ Res Best Manuscript Award)
8.Gong G*, Liu X*, Wang W. (2014). Regulation of Metabolism in Individual Mitochondria during Excitation-Contraction Coupling. Journal of Molecular Cellular Cardiology. 76: 235-246. (Equal contribution)  
9.Kim M, Hunter R, Garcia-Menendez L, Gong G, Yang Y, Kolwicz S, Xu J, Sakamoto K, Wang W, Tian R. (2014).  Mutation in The γ2-subunit of AMP-Activated Protein Kinase Stimulates Cardiomyocyte Proliferation and Hypertrophy Independent of Glycogen Storage. Circulation Research. 114 (6): 966-975. (Featured article)
10.Karamanlidis G, Garcia-Menendez L, Kolwicz S, Suthammarak W, Gong G, Sedensky M, Morgan P, Wang W, Tian R. (2013). Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure. Cell Metabolism. 18 (2): 239-250.
11.Gong G, Wang W. (2013). Confocal Imaging of Single Mitochondrial Superoxide Flashes in Intact Heart or in vivo. Journal of Visualized  Experiments (JoVE). 81: e50818, doi:10.3791/50818.
12.Wei-LaPierre L*, Gong G*, Gerstner B, Ducreux S, Yule D, Pouvreau S, Wang X, Sheu S, Cheng H, Dirksen R, Wang W. (2013). "Respective Contribution of Mitochondrial Superoxide and pH to Mt-cpYFP Flash Activity."  Journal Biological Chemistry. 288 (15): 10567~ 10577. (Equal contribution)
13. Huang Z, Zhang W, Gong G, Fang H, Zheng M, Wang X, Xu J, Dirksen R, Sheu S, Cheng H, Wang W. (2011). Response to “A Critical Evaluation of EpYFP as A Probe for Superoxide. Free Radical Biology and Medicine. 51 (10): 1937~1940.
14. Gong G, Qin Y, Huang W. (2011). Anti-Thrombosis Effect of Diosgenin from Dioscorea Zingiberensis C.H.Wright in Rodents. Phytomedicine. 2011, 18 (6): 458~463.
15. Gong G, Qin Y, Huang W, Zhou S, Wu X, Yang X, Li D. (2010). Protective Effects of Diosgenin in The Hyperlipidemic Rat Model and Human Vascular Endothelial Cells Against Hydrogen Peroxide-induced Apoptosis. Chemico-Biological Interactions. 184 (3): 366~375.
16. Gong G, Qin Y, Huang W, Zhou S, Yang X, Li D. (2010). Rutin Inhibits Hydrogen Peroxide-Induced Apoptosis through Regulating ROS-Mediated Mitochondrial Dysfunction Pathway in Human Umbilical Vein Endothelial Cells. European Journal of Pharmacology. 628 (1-3): 27~35.

        实验室欢迎有志于线粒体生物医学研究和生物药物开发的研究生和本科生报考和实习,同时欢迎具有生物医学相关研究经历的副研究员,研究助理和博士后加盟。

 

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