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李维达
来源:  作者:  发表时间:2012-08-29  阅读次数:12089次

姓        名:李维达
学        位:博士
导师情况:博士生导师
研究领域:干细胞与再生生物学(Stem Cell and Regenerative Biology),转分化(Transdifferentiation),糖尿病疾病模型及转化医学(Diabetes Modeling and Translational Medicine)。
Email:liweida@tongji.edu.cn
通讯地址:上海市杨浦区四平路1239号,同济大学生命科学与技术学院522室,邮编200092
 
研究方向
1.  通过干细胞技术探索糖尿病的细胞疗法
2.  胰腺转分化机制研究
3.  糖尿病致病病机制
4.  代谢疾病靶点研究

个人简介
        2003年毕业于南开大学,获得生物技术专业学士学位;2009年毕业于北京大学,获得细胞生物学专业博士学位, 2006年-2009年于北京生命科学研究所及北京大学联合培养,主要从事凋亡细胞清除机制的研究;2010年-2015年于哈佛大学干细胞研究所从事博士后研究,主要研究方向为通过干细胞和转分化技术开发糖尿病治疗的细胞疗法。2015年入选国家青年千人计划并入职同济大学生命科学与技术学院。

代表性文章
 

1. Cavelti-Weder C*, Li W*, Zumsteg A, Stemann-Andersen M, Zhang Y, Yamada T, Wang M, Lu J3, Jermendy A, Bee YM, Bonner-Weir S, Weir GC, Zhou Q (2016). Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine to beta-cells. Diabetologia, 59(3):522-32. (* equal contribution).

 

2.  Li, W.*, Cavelti, C.*, Zhang, Y.*, Clement, K.,Donovan S., Gonzalez, G., Zhu, J., Andersen, M., Xu, K., Hashimoto, T., Yamada, T., Nakanishi, M., Zhang, Y., Zeng, S., Gifford, D.,Meissener, A., Weir,G. and Zhou, Q (2014). Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells. Nature Biotechnology, 32(12):1223-1230.  (* equal contribution).

 

 

3. Li, W.*, Nakanishi, M.*, Zumsteg, A., Wright, C., Melton, D., and Zhou, Q. (2014).In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes.eLIFE, 3, e01846 (* equal contribution).

 

4. Cavelti, C.*, Li, W.*, Weir, C.G. and Zhou, Q. Direct lineage conversion of pancreatic exocrine to endocrine beta-cells in vivo with defined factors (2014). Methods in Molecular Biology,  1150:247-262  (* equal contribution).

 

5. Cronican, J.J. ,Beier, K.T. , Davis, T.N. , Tseng, J.C. , Li, W. , Thompson, D.B. , Shih, A.F. , May, E.M. , Cepko, C.L. , Kung, A.L. , Zhou, Q. and Liu, D.R. (2011). A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo.Chemistry and Biology, 18(7), 833-838.

 

6. Wang, X., Li, W.*, Zhao, D.* ,Liu, B.* , Shi, Y. , Chen, B. , Yang, H. , Guo, P. , Geng, X. , Shang, Z. , Peden, E. , Kage-Nakadai, E. , Mitani, S. and Xue, D. (2010). Caenorhabditiseleganstransthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nature Cell Biology, 12(7), 655-664  (* equal contribution).

 

7. Li, W., Zou, W., Zhao, D. ,Yan, J. ,Zhu, Z. , Lu, J. and Wang, X. (2009). C. elegansRabGTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5. Development, 136(14), 2445-2455.

 

8. Zou, W., Lu, Q., Zhao, D., Li, W., Mapes, J., Xie, Y. and Wang, X. (2009). Caenorhabditiselegansmyotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genetics, 5(10), e1000679.

 

9. Wang, X. , Liu, M. , Li, W. , Suh, C.D. , Zhu, Z. , Jin, Y. and Fan, Q. (2009). The function of a spindle checkpoint gene bub-1 in C. elegans development.PLoS One, 4(6), e5912.

 

10. Lu, Q., Zhang, Y., Hu, T., Guo, P., Li, W. and Wang, X. (2008). C. elegansRabGTPase 2 is required for the degradation of apoptotic cells. Development, 135(6), 1069-1080.

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