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唐凯临
来源:  作者:  发表时间:2014-09-24  阅读次数:5700次

 

 

     姓 名:唐凯临

学 位:博士

导师情况:硕士生导师

研究方向:1、中药信息学:小分子组效关系、靶点分类预测;药物作用机理分析。

2、高通量数据:发展及应用生物信息算法,整合多维数据。

E-mailkltang@tongji.edu.cn

通讯地址:上海市杨浦区四平路1239号同济大学生命科学与技术学院

 个人简介:

现任同济大学转化医学高等研究院副研究员。1999年毕业于同济大学化学系。2007年毕业于同济大学化学系,获博士学位。2007-2013年在上海生物信息技术研究中心,副研究员。2013年至今在同济大学生命科学与技术学院从事教学和科研工作。2012年至今兼任上海理工大学联合培养硕士生导师。

主持科研项目

1.国家自然科学基金(编号:30900832)

2.上海中医药大学肝肾疾病病症重点实验室开放基金项目

合作科研项目

1.科技部863(编号:2012AA020404)

2.国家自然科学基金(编号:20675057;20705024)

专利

曹志伟,叶浩,唐凯临,李亦学,一种基于生物过程预测药物新疗效的方法及应用。

发表论文

  1. Qi T, Qiu T, Zhang Q, Tang K, Fan Y, Qiu J, Wu D, Zhang W, Chen Y, Gao J, Zhu R, Cao Z,SEPPA 2.0—more refined server to predict spatial epitope considering species of immune host and subcellular localization of protein antigen,Nucl. Acids Res. 2014,42 (W1): W59-W63.
  2. Peng Fu, Linlin Yang, Yi Sun, Li Ye, Zhiwei Cao and Kailin Tang*,Target network differences between western drugs and Chinese herbal ingredients in treating cardiovascular disease,BMC Bioinformatics 2014, 15(Suppl 4):S3
  3. Haoqi Sun, Haiping Wang, Ruixin Zhu, Kailin Tang, Qin Gong, Juan Cui, Zhiwei Cao,Qi Liu,iPEAP: integrating multiple omics and genetic data for pathway enrichment analysis,Bioinformatics,2014,30(5): 737-739
  4. Hong Kang, Kailin Tang, Qi Liu, Yi Sun, Qi Huang, Ruixin Zhu, Jun Gao, Duanfeng Zhang, Chenggang Huang and Zhiwei Cao, HIM-herbal ingredients in-vivo metabolism database, 2013, Journal of Cheminformatics, 2013, 5:28
  5. Chao Ma, Kailin Tang, Qi Liu, Ruixin Zhu, Zhiwei Cao, Calmodulin as a Potential Target by Which Berberine Induces Cell Cycle Arrest in Human Hepatoma Bel7402 Cells, Chemical Biology & Drug Design, 2013, 81(6):775–783
  6. Yi Sun, Ruixin Zhu, Hao Ye, Kailin Tang, Jing Zhao, Yujia Chen, Qi Liu and Zhiwei Cao, Towards a bioinformatics analysis of anti-Alzheimer’s herbal medicines from a target network perspective, Briefings in Bioinformatics, 2013, 14(3):327-43
  7. 刘雪平, 杨琳琳, 付鹏, 唐凯临*, 曹志伟*,活血化瘀中药抗肝纤维化作用计算药理探讨,生物物理学报,2012, 28(12):971-982
  8. Linlin Yang*, Kailin Tang*, Ying Qi, Hao Ye, Wenlian Chen, Yongyu Zhang, Zhiwei Cao. Potential metabolic mechanism of girls’central precocious puberty: a network analysis on urine Metabonomics data.BMC Systems Biology 2012, 6(Suppl 3):S19
  9. 杨琳琳,叶浩,唐凯临*,曹志伟*. 基于靶基因比较MicroRNAs与HBV蛋白的作用模式. 科学通报,2012, 57(19), 1755-1762
  10. Hao Ye, Kailin Tang, Linlin Yang, Zhiwei Cao, Yixue Li,Study of drug function based on similarity of pathway fingerprint,Protein & Cell,2012, 3(2): 132–139
  11. YE Hao, YANG LinLin, CAO ZhiWei, TANG KaiLin, LI Yixue, A pathway profile-based method for drug repositioning,Chinese Science Bulletin, 2012,57(17): 2106-2112
  12. YE Li, YE Hao, LIU XuePing, YANG LinLin, CAO ZhiWei, TANG KaiLin*, Pathway-Pathway Network Based Study on the Therapeutic Mechanisms of Salvianolic acid B Regulates cardiovascular diseases, Chinese Science Bulletin, 2012,57(14): 1672-1679
  13. Li-Xing Feng, Chun-Jie Jing,Kai-Lin Tang,Lin Tao,Zhi-Wei Cao,Wan-Ying Wu,Shu-Hong Guan,Bao-Hong Jiang,Min Yang,Xuan Liu,De-An Guo, Clarifying the signal network of salvianolic acid B using proteomic assay and bioinformatic analysis, PROTEOMICS, 2011, Volume 11, Issue 8, 1473-1485
  14. Tang K, Zhu R, Li Y, Cao Z. Discrimination of Approved Drugs from Experimental Drugs by Learning Methods, BMC Bioinformatics 2011, 12:157
  15. Ye H, Ye L, Kang H, Zhang D, Tao L, Tang K, Liu X, Zhu R, Liu Q, Chen YZ, Li Y, Cao Z. HIT: linking herbal active ingredients to targets, Nucleic Acids Research, 2011, Vol. 39, D1055–D1059
  16. Tang KL, Yao WJ, Li TH, Li YX, Cao ZW. Cancer Classification from The Gene Expression Profiles By Discriminant Kernel-PLS, Journal of Bioinformatics and Computational Biology, Vol. 8, S1 (2010) 147–160
  17. Zhao, J; Geng, C; Tao, L; Zhang, DF; Jiang, Y; Tang, KL; Zhu, RX; Yu, H; Zhang, WD; He, FC; Li, YX; Cao, ZW Reconstruction and Analysis of Human Liver-Specific Metabolic Network Based on CNHLPP Data, Journal of Proteome Research, 2010, 9, 1648–1658
  18. Tang KL, Li TH, Xiong WW, Chen K. Ovarian cancer classification based on dimensionality reduction for SELDI-TOF data. BMC Bioinformatics. 2010 Feb 27;11:109
  19. Wenwei Xiong, Tonghua Li, Kai Chen, and Kailin Tang,Local combinational variables: an approach used in DNA-binding helix-turn-helix motif prediction with sequence information,Nucleic Acids Res. 2009, 37(17): 5632–5640
  20. Kai-lin TANG, Tong-hua LI,Kai CHEN,QSAR Studies on PCDD/Fs by Kernel PLS,Chemical Research in Chinese Universities,Volume 24, Issue 5, 2008, 541-545
  21. 唐凯临,李通化,陈开, 多肽保留时间预测的研究, 计算机与应用化学,2008,vol25,No.2,145-147
  22. Kailin Tang, Tonghua Li, Kai Chen, Jinyan Huang, Application of kernel method to classify SELDI-TOF proteomics data, Computers and Applied Chemistry, 2007,Vol.24,No.1, 107-109
  23. Kailin Tang, Tonghua Li, Comparison of different partial least-squares methods in quantitative structure–activity relationships, Analytica Chimica Acta 476 (2003) 85-92
  24. Kailin Tang, Tonghua Li, Combining PLS with GA-GP for QSAR, Chemometrics and Intelligent Laboratory Systems 64 (2002) 55-64

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