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毛志勇
来源:  作者:  发表时间:2012-03-01  阅读次数:29863次

姓         名:毛志勇  

行政职务:

学         位:博士

导师情况:博士生导师

研究领域:生物化学与分子生物学

研究方向:1、哺乳动物中DNA双链断裂修复的调控机制

                      2、DNA双链断裂修复对衰老以及癌症的影响
                      3、诱导性多能干细胞(iPS Cells)中DNA双链断裂修复的机制研究

     E-mail:zhiyong_mao@tongji.edu.cn

联系电话:021-65978166

通讯地址:上海市四平路1239号,同济大学生命科学与技术学院(200092)

个人简介:

        毛志勇,教授,博士生导师。2002年毕业于南京大学,获生物科学学士学位;2004年毕业于南京大学植物学专业,获得植物学硕士学位;2010年毕业于美国罗彻斯特大学,获博士学位,主要从事DNA双链断裂修复的分子生物学机制的研究。2010年-2012年于罗彻斯特大学生物系从事博士后研究,主要研究方向是衰老以及肿瘤与DNA修复之间的关系。
现已在Science、PNAS、Cell Death Differentiation、Cell Reports、Oncogene、MCB等学术期刊上发表通讯作者或第一作者论文20余篇。2012年入选国家青年千人计划,2013年担任科技部“973”计划青年项目首席科学家,2016年获国家自然科学基金委优秀青年项目资助。

 

代表性文章:

1. Zhang F, Tang H, Jiang Y*, Mao Z*. The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression. Oncogene. May 8, 2017; doi:10.1038/onc.2017.127 * Corresponding authors.
2. Chen W, Liu N, Zhang H-X, Zhang H-P, Qiao J, Jia W, Zhu S, Mao Z*, Kang J*. Sirt6 promotes DNA end joining in iPS cells derived from old mice. Cell Reports. 2017 March 21: 18: 2880–2892. * Corresponding authors.
3. Li Z, Zhang W, Chen Y, Guo W, Zhang J, Tang H, Xu Z, Zhang H, Tao Y, Wang F, Jiang Y, Sun FL, Mao Z*. Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans. Cell Death Differ. 2016 Nov 1;23(11):1765-1777. doi: 10.1038/cdd.2016.65. Corresponding author.
4. Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao Z*, Sun FL*. RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1. Mol Cell Biol. 2015 Jan 15;35(2):406-16. * Corresponding authors.
5. Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, Xu X, Van Meter M, Seluanov A, Gorbunova V, Mao Z*. SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Cell Cycle. 2015;14(2):269-76. doi: 10.4161/15384101.2014.980641. * Corresponding author.
6. Cao Y, Xu Y, Zhang L, Li Z, Jiang Y, Tian X, Seluanov A, Gorbunova V*, Mao Z*. Utilization of Rad51C promoter for transcriptional targeting of cancer cells. Oncotarget. 2014 Apr 15;5(7):1805-11. * Corresponding authors.
7. Xu Y, Ohms SJ, Li Z, Wang Q, Gong G, Hu Y, Mao Z*, Shannon MF*, Fan JY*. Changes in the Expression of miR-381 and miR-495 Are Inversely Associated with the Expression of the MDR1 Gene and Development of Multi-Drug Resistance. PLoS One. 2013 Nov 26;8(11):e82062. * Corresponding authors.
8. Vaidya A, Mao Z, Tian X, Spencer B, Seluanov A, Gorbunova V. Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age. PLoS Genet. 2014 Jul 17;10(7):e1004511.
9. Hine CM, Li H, Xie L, Mao Z, Seluanov A, Gorbunova V. Regulation of Rad51 promoter. Cell Cycle. 2014 Jul 1;13(13):2038-45.
10. Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, Mao Z, Nevo E, Gorbunova V, Seluanov A. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature. 2013 Jul 18;499(7458):346-9.
11. Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11800-5.
12. Mao Z, Ke Z, Gorbunova V, Seluanov A. Replicatively senescent cells are arrested in G1 and G2 phases. Aging (Albany NY). Jun;4(6):431-5.
13. Van Meter M, Mao Z, Gorbunova V and Seluanov A. Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. Aging (Albany NY). 2011 Sep;3(9):829-35.
14. Van Meter M, Mao Z, Gorbunova V and Seluanov A. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle. 2011 Sep. 15; 15:18.
15. Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V. SIRT6 promotes DNA repair under stress by activating PARP1. Science. 17 June 2011: 1443-1446.
16. Seluanov A, Mao Z, Gorbunova V. Analysis of DNA Double-Strand Break (DSB) Repair in Mammalian Cells. J Vis Exp. 2010 Sep 8;(43).
17. Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao Z, Catania KC, Gorbunova V. Naked mole-rat cells are hypersensitive to contact inhibition – a clue to extraordinary cancer resistance. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46): 19352-7.
18. Mao Z*, Jiang Y*, Liu X, Seluanov A, Gorbunova V. DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia. 2009 Jul; 11(7):683-691. * These authors contributed equally to this work.
19. Mao Z*, Bozzella M*, Seluanov A, Gorbunova V. DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle. 2008 Sep 15; 7:18, 1-5. * These authors contributed equally to this work.
20. Mao Z, Bozzella M, Seluanov A, Gorbunova V. Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst). 2008 Oct 1;7(10):1765-71.
21. Gorbunova V, Seluanov A, Mao Z, Hine C. Changes in DNA repair during aging. Nucleic Acids Res. 2007;35(22):7466-74. 
22. Mao Z, Seluanov A, Jiang Y, Gorbunova V. TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13068-73.
23. Li PF, Mao ZY, Rao XJ, Wang XM, Min MZ, Qiu LW and Liu ZL. Biosorption of uranium by lake-harvested biomass from a cyanobacterium bloom. Bioresour Technol. 2004 Sep;94(2):193-5.
24. Wang X, Zhao X, Mao ZY, Wang XM and Liu ZL. Neuroprotective effect of docosahexaenoic acid on glutamate-induced cytotoxicity in rat hippocampal cultures. Neuroreport. 2003 Dec 19;14(18):2457-61.

 

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