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孙方霖
来源:  作者:  发表时间:2011-12-08  阅读次数:20233次

 

姓        名: 孙方霖

行政职务:同济大学校长助理
                      转化医学高等研究院院长

学         位:博 士

导师情况:博士生导师

研究领域:表观遗传学

研究方向:表观遗传调控的分子机制与功能
                     干细胞分化与癌症形成的表观遗传调控网络 

      E-mailsfl@tongji.edu.cn

联系电话:021-65980910

通讯地址:上海市四平路1239号,同济大学生命科学与技术学院(200092)

个人简介

       孙方霖,教授,博士生导师。现任同济大学校长助理、转化医学高等研究院院长。1993-1997就读于英国剑桥大学并获博士学位;1997-2001在美国华盛顿大学(St. Louis)生物系从事博士后研究;2001年 受聘于瑞士FMI(Friedrich Miecher Institute)生物医学研究所担任研究组组长;2006年回国并入选清华大学"百人计划",受聘于清华大学医学院担任教授、博导;2006年获国家自然科学基金委的"国家杰出青年科学基金"资助;2007年获聘第八届教育部生命科学(表观遗传学)长江学者特聘教授;2009年获聘“百千万人才工程”国家级人选;2010年获教育部推荐享受政府特殊津贴;2011年为科技部“973”项目首席科学家。

 

代表性文章:

1. Sun J, Wei HM, Xu J, Chang JF, Yang Z, Ren X, Lv WW, Liu LP, Pan LX, Wang X, Qiao HH, Zhu B, Ji JY, Yan D, Xie T, Sun FL*, Ni JQ* . (2015). Histone H1-mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation. Nature Communication. 2015 Nov 19;6:8856.(*通讯作者)

2. Pan L, Xie W, Li KL, Yang Z, Xu J, Zhang W, Liu LP, Ren X, He Z, Wu J, Sun J, Wei HM, Wang D, Xie W, Li W, Ni JQ*, Sun FL*.(2015). Heterochromatin remodeling by CDK12 contributes to learning in Drosophila. PNAS. 2015 Nov 10;112(45):13988-93.(*通讯作者)

3. Wang C, Chang JF, Yan H, Wang DL, Liu Y, Jing Y, Zhang M, Men YL, Lu D, Yang XM*, Chen S*, Sun FL*. (2015). A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis. Oncotarget. 2015 Oct 6;6(30):29599-613.(*通讯作者)

4. Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao Z*, Sun FL*. (2015). RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1. Mol Cell Biol. 2015 Jan;35(2):406-16.(*通讯作者)

5. Zhao L, Wang DL, pu Y, Chen S, Sun FL.*(2013). Histone acetyltransferase hMOF promotes S phase entry and tumorigenesis in lung cancer. Cell Signal. 2013 Aug;25(8):1689-98 (*通讯作者)

6. Lv W, Wei HM, Wang DL Ni JQ and Sun FL*(2012)Depletion of histone deacetylase 3 antagonizes PI3K-mediated tissue overgrowth through the acetylation of histone H4 at lysine 16, J Cell Sci. 2012 Nov 15;125(Pt 22):5369-78 (*通讯作者)

7. Chen S, p J, Wang DL, Sun FL* (2012) Histone H2B lysine 120 monoubiquitination is required for embryonic stem cell differentiation. Cell Res. 2012 Sep;22(9):1402-5 (*通讯作者)

8. Chen S, Wang DL, pu Y, Zhao L, Sun FL* (2012) RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanisms. Mol Cell Biol. 32(2):576-87. (*通讯作者)

9. Chen S, Wei HM, Lv WW, Wang DL, Sun FL*(2011) E2 pgase dRad6 regulates DMP53 turnover in Drosophila. J Biol Chem. 286(11):9020-30(*通讯作者)

10. Zhang D, Wang D, Sun F*(2011) Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. Chromosoma. 120(1):97-108(*通讯作者)

11. Ni, J-Q, pu L-P, Hess D., Rietdorf J.,1 and Sun F-L* (2006). Drosophila ribosomal proteins are associated with pnker histone H1 and suppress gene transcription. Genes & Development  20: 1959-73 (*通讯作者)

12. pu L.-P., Ni J.-Q., Shi Y-D, Oakeley, E. and Sun F-L* (2005). Sex-specific role of Drosophila HP1 in chromatin and transcription. Nature Genetics 37: 1361-66 (*通讯作者)

13. De Lucia F, Ni JQ, Vaillant C, Sun F-L.* (2005). HP1 modulates the transcription of cell-cycle regulators in Drosophila melanogaster. Nucleic Acids Res. 33: 2852-58. (*通讯作者) 

14. Sun F.L., Hayes K., Simpson C.L., Lee S., Colpn L., Wuller J., Eissenberg J., Elgin S.C.R. (2004). Cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four.  Mol.Cell. Biol, 24: 8210-20.

15. Sun F.L. Cuaycong M.H. and Elgin S.C.R. (2001). Long-range nucleosome ordering is associated with gene silencing in Drosophila melanogaster pericentric heterochromatin. Mol. Cell. Biol. 21: 2867-79.

16. Sun F.L. Cuaycong M.H. Craig C. A. Wallrath L.L. Locke J. and Elgin S.C.R. (2000). The fourth chromosome of Drosophila melanogaster: interspersed euchromatic and heterochromatic domains. Proc Natl Acad Sci U S A. 97: 5340-45.

17. Sun F.L and Elgin S.C.R. (1999). Putting boundaries on silence. Cell, 99: 459-6

18. Sun F.L., Dean W.L., Kelsey G., Allen N. D. and Reik W. (1997). Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome. Nature, 389: 809 – 815

 

 

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