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薛雷
来源:  作者:  发表时间:2011-12-08  阅读次数:8829次

 

姓         名:薛 雷

学         位:博士

导师情况:博士生导师

研究领域:分子遗传学

研究方向

1.   肿瘤发生的分子遗传学机制
The molecular and genetic mechanism of tumorigenesis.
2.    细胞凋亡的分子生物学机制
The molecular mechanism of apoptosis.
3.   阿尔茨海默病的分子生物学机制
The molecular mechanism of Alzheimer's disease.
4.  Pax基因对胚胎发育和器官形成的调控作用及机制
Genetic regulation of embryonic development and organogenesis by Pax genes.
5.  治疗肿瘤迁移和神经退行性疾病的中药筛选
A screen for Chinese herbal medicines against tumor metastasis and neurodegenerative diseases.    

     E-maillei.xue@mail.tongji.edu.cn

通讯地址: 上海市四平路1239号,同济大学生命科学与技术学院(200092)

个人简介:

      北京大学生物系学士,中国科学院上海细胞生物学研究所硕士,瑞士苏黎世大学分子生物学研究所博士,美国耶鲁大学医学院博士后。 历任耶鲁大学医学院副研究员 (Associate Research Scientist),霍华德修斯医学研究院 (Howard Hughes Medical Institute) 研究专家 (Research Specialist),自2008年9月起任同济大学生命科学与技术学院教授,博导,首席科学家。

 

研究领域:

    JNK信号通道在细胞增殖、迁移、凋亡、应激反应和个体衰老中起着至关重要的作用,其失调可导致发育缺陷和过早衰老,并和肿瘤发生和迁移、免疫失调、阿尔兹海默症及多种重要疾病的发生与发展密切相关。

    近年来,我们以果蝇为模式动物进行遗传筛选,找到了JNK信号通道上30多个新的基因,目前已分析鉴定其中部分基因,成果发表在Developmental Cell和Science 等国际顶级学术杂志。我们将继续研究其余的基因,探索它们在JNK信号通道中的分子功能,阐明其在细胞凋亡、个体衰老、癌症及阿尔兹海默症中的作用机制。

    选择是一种行为,也代表着智慧,其调控分子和作用机制仍有待破解。我们利用果蝇的择偶方式和取向,研究选择的分子机制以及调控选择的遗传因素。

    我们还建立了癌症和阿尔兹海默症的果蝇模型,并利用这些疾病模型筛选和检验各类中药成分对延缓衰老、治疗癌症和老年痴呆症等疾病的效果。

 

代表性论文:

  • X Wang, Z Wang, Y Chen, X Huang, Y Hu, R Zhang, M S Ho and L Xue* (2014)FoxO Mediates APP-Induced AICD-Dependent Cell Death. Cell Death Dis. 5, e1233; doi:10.1038/cddis.2014.196.
  • Y Hu, Y Han, X Wang and L Xue* (2014) Aging-related Neurodegeneration Eliminates Male Courtship Choice in Drosophila. Neurobiology of Aging 35,2174-2178.
  • X Ma, W Li, H Yu, Y Yang, M Li, L Xue* and T Xu* (2014) Bendless modulates JNK-mediated cell death and migration in Drosophila. Cell Death Diff. 21, 407-415.
  • Y Wang and L Xue* (2014) Mapping It out: A Novel Signaling Pathway Linking Aβ-PrPc-Fyn Complex to Cognitive Impairment in Alzheimer’s Disease. Adv. Alz. Dis. 3, 20-23.
  • X Ma, Y Shao, H Zheng, M Li, W. Li and L. Xue* (2013) Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila. Cell Death Dis. e864.
  • H. Yang, W. Li, H. Yu, R. Yuan, Y. Yang, K. Pung, P. Li and L. Xue* (2013) Physiological Effects of L-Theanine on Drosophila melanogaster. Molecules 18,13175-13187
  • X. Ma, L. Yang, Y. Yang, M. Li, W. Li* and L. Xue* (2013) dUev1a Modulates TNF-JNK Mediated Tumor Progression and Cell Death in Drosophila. Dev. Biol. 380, 211-221.
  • L. Pung, X. Wang, M. Li, L. Xue* (2013) The role of APP in Alzheimer’s disease. Adv. Alz. Dis. 2, 60-65
  • X. Ma, J. Huang, Y. Yang, W. Li and L. Xue* (2012) NOPO Modulates Egr- induced JNK- independent cell death in Drosophila. Cell Res. 22,425-431.
  • W. Li, S. Li, S. Zhang and L. Xue* (2012) A Broad Expression Profile of the GMR-GAL4 driver in Drosophila melanogaster. Genet. Mol. Res.11,1997-2002.
  • H. Huang, G. Du, H. Chen, X. Liang, C. Li, N. Zhu, L. Xue, J. Ma and R. Jiao (2011) Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus. Development 138, 2477-2485.
  • J. Liu*, M. Ghanim*, L. Xue* et al., (2009) Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer. Science 323:1218-1222. (* Equal contribution)
  • L. Xue, T. Igaki, E. Kuranaga, H. Kanda, M. Miura and T. Xu (2007) Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Dev. Cell 13:446-454.
  • L. Xue and M. Noll. (2002) Dual role of the Pax gene paired in accessory gland development of Drosophila. Development 129:339-46.
  • L. Xue, X. Li and M. Noll. (2001) Multiple protein functions of paired in Drosophila development and their conservation in the Gooseberry and Pax3 homologs. Development 128:395-405.
  • L. Xue and M. Noll. (2000) Drosophila female sexual behavior induced by sterile males showing copulation complementation. Proc. Natl. Acad. Sci. USA 97: 3272-3275.
  • L. Xue and M. Noll. (1996) The functional conservation of proteins in evolutionary alleles and the dominant role of enhancers in evolution. EMBO. J., 15: 3722-3731.

 

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