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朱融融
来源:  作者:  发表时间:2011-11-26  阅读次数:15726次

       

姓    名:朱融融    
性   别:女    
所属部门:生命科学与技术学院    
行政职务:        
学    位:博士    
导师情况: 硕导/博导    研究领域:    纳米生物医药
研究方向:1、纳米载药体系靶向肿瘤治疗 

                    2、纳米材料在干细胞分化和脊髓损伤修复中的作用

                    3、纳米材料搭载大麻素受体激动剂在神经退行性疾病治疗上的应用

E-mail: rrzhu@tongji.edu.cn
联系电话:021-65982286
通讯地址:上海市四平路同济大学医学楼1119
 

情况介绍

个人简介:

       现任同济大学生命科学与技术学院副研究员,硕士/博士生导师,中国生物化学与分子生物学理事。2002年毕业于同济大学环境科学与技术学院;2007年获得同济大学生命科学与技术学院博士学位。2009年赴美国石溪大学作访问学者。已主持或参与国家、省部级项目10余项,已发表被SCI摘录的学术论文20余篇,申请专利4项。

 

研究领域(具体内容):
纳米材料作为载药体系在神经退行性疾病和抗肿瘤方向上的应用;
纳米材料维持胚胎干细胞干性以及诱导定向分化的研究。
专业业绩(承担项目、发表论文、教学成果):


负责承担科研项目:

  1. 国家自然科学基金面上项目,81671105,大麻素受体CB2作为帕金森病治疗新靶点的作用及其分子机制研究,2017/01-2020/12,52万元,在研,主持;
  2. 国家重点研发计划——课题三子课题,2016YFA0100800,基于动员内源性神经干细胞修复脊髓损伤的机制与转化研究,2016/07-2021/07,100万,主持
  3. 国家自然科学青年基金,“基于大麻素受体CB1的固体脂质纳米粒治疗抑郁症研究” ,2013-2016,23万,主持
  4. 中央高校基本科研业务费学科交叉类(面上)项目,“Avastin介导的LDH@SiO2-DOX纳米复合药物载体抗肺癌机制研究”, 2015-2016,20万,主持
  5. 国家博士点基金“纳米TiO2对亚单位疫苗的佐剂效应”, 20090072120019,2010年1月~2012年12月,主持;
  6. 中央高校基本科研业务费基础研究人才培养计划, ‘SLN-姜黄素治疗哮喘及其信号通路研究 ’2011-2012, 主持;
  7. 上海市教委晨光计划“蛋白酶分子水平多尺度纳米TiO2生物效应研究”, 2008CG26,2007年12月~2010年12月,主持 ;
  8. 09年度校优青资助“羟基化金红石型纳米TiO2作为免疫佐剂的研究”,2000144024; 2009年12月~2011年12月,主持;
  9. 973项目“心脏中内源性H2S生成调控及其传递”, 2010CB912604, 项目骨干;


发表文章列表(近5年):
近五年代表性论文(* 通讯作者)

  1. Yanjing Zhu#; Rongrong Zhu#*; Mei Wang; Bin Wu; Xiaolie He; Yechang Qian*; Shilong Wang* Anti-metastatic and Anti-angiogenic activities of Core-shell SiO2@LDH loaded with Etoposide in Non-small Cell Lung Cancer. Advanced Science 2016, 3(11): 3(11): 1600229,封面文章.
  2. Xiaolie He, # Yanjing Zhu, # Mei Wang, Guoxin Jing, Rongrong Zhu*, and Shilong Wang*. Antidepressant effects of curcumin and hU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression. Int J Nanomedicine. 2016
  3. Zhu, Rongrong;   Wang, Qingxiu;   Zhu, Yanjing;   Wang, Zhaoqi;   Zhang, Haixia;   Wu, Bin;   Wu, Xianzheng;   Wang, Shilong, pH sensitive nano layered double hydroxides reduce the hematotoxicity and enhance      the anticancer efficacy of etoposide on non-small cell lung cancer., Acta Biomaterialia,2016,29:320-332  
  4. Youjun Wu1, Rongrong Zhu1, Xiaoyu Sun1, Zhaoqi Wang1, Wenrui  Wang1, Mei Wang1, Hui Liu2* & Shilong Wang1*,Size dependent effects of layered double hydroxide nanoparticles on cellular functions of mouse embryonic stem cells, Nanomedicine, 2015. 1743-5889,
  5. Yanjing Zhu, Youjun Wu, Haixia Zhang, Zhaoqi Wang, Yechang Qia*, Shilong Wang*,Rongrong Zhu*, The enhanced anti-metastasis efficiency of etoposide by the delivery of LDH nanoparticles through caveolae-mediated cellular uptake and the regulation of mTOR/AKT and STAT pathways, J. Biomed.Nanotechnol. 2015,11(12),2158-2168,
  6. Youjun Wu, Rongrong Zhu, Yang Zhou, Jun Zhang, Wenrui Wang, Xiaoyu Sun,Xianzheng Wu, Liming Cheng, Jing Zhang* and Shilong Wang*,Layered double hydroxide nanoparticles promote self-renewal of mouse embryonic stem cellsthrough the PI3K signaling pathway, Nanoscale, 2015, 7, 11102–11114  
  7. Jiao Wang, Haoyue Wang, Rongrong Zhu, Qiang Liu, Jian Fei*,Shilong Wang *,Anti- inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1b transgenic mice subjected to the lipopolysaccharide-induced sepsis. Biomaterials ,2015,53, 475-483.
  8. Jiao Wang1, Rongrong Zhu1, Dongmei Sun1, Xiaoyu Sun1, Zhengsong Geng1, Hui Liu2*, Shi-Long Wang1* Intracellular Uptake of Curcumin-Loaded Solid Lipid Nanoparticles Exhibit Anti-inflammatory Activities Superior to Those of Curcumin through the NF-B Signaling Pathway, J. Biomed.Nanotechnol. 2015,Vol. 11, 403–415
  9. Jiao Wang1, Rongrong Zhu1, Xiaoyu Sun1, Yanjing Zhu1, Hui Liu2*, Shi-long Wang1* Intracellular uptake of etoposide-loaded solid lipid nanoparticles induces an enhancing inhibitory effect on gastric cancer through mitochondria-mediated apoptosis pathway. Int J Nanomedicine. 2014:9 3987–3998.
  10. Rongrong Zhu, Yanjing Zhu, Min Zhang, Yu Xiao, Xiling Du, Hui Liu, ShilongWang*, The induction of maturation on dendritic cells by TiO2 and Fe3O4@TiO2 nanoparticles via NF-κB signaling pathway,Materials Science and Engineering C 39 (2014) 305–314
  11. Jin Wang, Rongrong Zhu,Bo Gao,Bin Wu,Kun Li, Xiaoyu Sun,Hui Liu*, Shilong Wang*, The DNA vaccine delivery function of SiO2@ LDH  Nanoparticles on the activation of macrophage for the anti-HBV immune response enhancement  through NF-κB signaling pathway, Biomaterials, 2014, 35, 466-478,
  12. Rongrong Zhu, Xianzheng Wu, Yu Xiao, Bo Gao, Qian Xie, Hui Liu, and Shilong Wang*,,Synergetic Effect of SLN-Curcumin and LDH-5-Fu on SMMC-7721 Liver Cancer Cell Line, Cancer Biother Radiopharm. 2013 Oct;28(8):579-87.
  13. Wenrui Wang#, Rongrong Zhu#, Qian Xie, Ang Li, Yu Xiao, Kun Li, Hui Liu, Daxiang Cui, Yihan Chen, Shilong Wang. Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in Solid lipid nanoparticles. International journal of nanomedcine. 2012:7 3667–3677
  14. Rong-Rong Zhu, Wen-Rui Wang, Xiao-Yu Sun a, Hui Liu b,*, Shi-Long Wang a,** Enzyme activity inhibition and secondary structure disruption of nano-TiO2 on pepsin,Toxicology in Vitro,2010 ,24 ,1639–1647


专利:

  1. RIGAS, Basil; MACKENZIE, Gerardo; YU, Sun; HUANG, Liqun; ZHU, Rongrong,NIE, Ting。COMBINATION TREATMENTS AND FORMULATIONS FOR CANCER,美国,WO2011130486
  2. 一种地塞米松磷酸钠/层状双氢氧化物作为治 汪世龙, ,孙晓宇,王文锐 朱融融 疗哮喘药物的应用及其制备方法,2015.1.14-2034.9.23,中国,CN201410485883.X。
  3. 无机纳米材料层状双氢氧化物在小鼠胚胎干 汪世龙,孙晓宇, ,吴又君 朱融融 细胞培养中的应用,2014.8.6-2034.4.11,上海,CN201410142469.9

 

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