副教授

刘文强

姓        名:刘文强

学        位:博士

导师情况:硕士生导师

研究领域:发育与生殖生物学

研究方向
                  1.哺乳动物及人早期胚胎发育调控。 
                  2.核移植胚胎重编程机制。 
                  3.不育不孕的遗传学机制及辅助生殖技术。
E-mailliuwenqiang@tongji.edu.cn
联系电话:021-65982276
通讯地址:上海市四平路1239号同济大学生命科学与技术学院
实验室网址http://life.tongji.edu.cn/gaolab/

 

个人简介:
          2007年毕业于西北农林科技大学,获学士学位;2010年毕业于西北农林科技大学,获硕士学位;2014年毕业于中国农业大学/北京生命科学研究所,获博士学位;2014年8月-2017年2月于同济大学附属第一妇婴保健院,任助理研究员。现为同济大学附属第一妇婴保健院副研究员。主要从事早期胚胎发育和人辅助生殖研究。近年来发表 SCI 论文 20 余篇,其中以第一或通讯作者(兼共同)在 Nature,Cell Stem Cell, Cell Reports,Cell Discovery等知名学术期刊发表论文7 篇,并参与多个课题研究工作,相关成果发表在 Nature, Cell Stem Cell, Nature Communications 等国际学术期刊上。现主持国家自然基金项目两项,并以骨干身份参与科技部“国家重点研发计划干细胞及转化研究重点专项”两项,并先后获得了上海市青年拔尖人才,上海市科技启明星,上海市卫生计生系统优秀青年人才和晨光计划项目的支持。

发表论文
1.Rui Gao#, Chenfei Wang#, Yawei Gao#, Wenchao Xiu, Jiayu Chen, Xiaochen Kou, Yanhong Zhao, Yuhan Liao, Dandan Bai, Zhibin Qiao, Lei Yang, Mingzhu Wang, Ruge Zang, Xiaoyu Liu, Yanping Jia, Yanhe Li, Yalin Zhang, Jiqing Yin, Hong Wang, Xiaoping Wan, Wenqiang Liu*, Yong Zhang*, Shaorong Gao*. Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos. Cell Stem Cell, 2018,23 (3), 426-435 (*Co-correspondence)
2.Xiaoyu Liu#, Chenfei Wang#, Wenqiang Liu#, Jingyi Li#, Chong Li, Xiaochen Kou, Jiayu Chen, Yanhong Zhao, Haibo Gao, Hong Wang, Yong Zhang*, Yawei Gao*&Shaorong Gao*. Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos. Nature, 2016, 537, 558–562 (#co-first authors)
3.Wenqiang Liu#, Xiaoyu Liu#, Chenfei Wang#, Yawei Gao#*, Rui Gao, Xiaochen Kou, Yanhong Zhao, Jingyi Li, You Wu, Wenchao Xiu, Su Wang, Jiqing Yin, Wei Liu, Tao Cai, Hong Wang, Yong Zhang*, Shaorong Gao*. Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing. Cell Discovery, 2016, 2:16010 (#co-first authors)
4. Wenqiang Liu#, Kunming Li#, Dandan Bai#, Jiqing Yin#, Yuanyuan Tang, Fengli Chi, Linfeng Zhang, Yu Wang, Jiaping Pan, Shanshan Liang, Yi Guo, Jingling Ruan, Xiaochen Kou, Yanhong Zhao, Hong Wang, Jiayu Chen*, Xiaoming Teng*, Shaorong Gao*. Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility. Human Genetics, 2017, 136 (8), 975-985 (#co-first authors)
5. Yi Guo#, Wen qiang Liu#, Yu Wang, Jiaping Pan, Shanshan Liang, Jingling Ruan, Xiaoming Teng*. Polarization microscopy imaging for the identification of unfertilized oocytes following short-term insemination. Fertility and Sterility, 2017, 108 (1), 78-83 (#co-first authors)  
6.Bingjie Zhang#, Hui Zheng#, Bo Huang#, Wenzhi Li#, Yunlong Xiang, Xu Peng, Jia Ming, Xiaotong Wu, Yu Zhang, Qianhua Xu, Wenqiang Liu, Xiaochen Kou, Yanhong Zhao, Wenteng He, Chong Li, Bo Chen, Yuanyuan Li, Qiujun Wang, Jing Ma, Qiangzong Yin, Kehkooi Kee, Anming Meng, Shaorong Gao, Feng Xu, Jie Na*&Wei Xie*. Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature, 2016, 537, 553–557
7. Wenqiang Liu, Jiqing Yin, Xiaochen Kou, Yonghua Jiang, Haibo Gao, Yanhong Zhao, Bo Huang, Wenteng He, Hong Wang, Zhiming Han*, and Shaorong Gao* Asymmetric reprogramming capacity of parental pronuclei in mouse zygotes. Cell reports, 2014, 6 (6): 1008-1016 
8. Wenqiang Liu, Jiqing Yin, Guimin Zhao, Yan Yun, Shujun Wu, Jones K.T., and Anmin Lei*. Differential regulation of cyclin B1 degradation between the first and second meiotic divisions of bovine oocytes. Theriogenology, 2012, 78, 1171-1181
9. Shuai Gao#, Caihong Zheng#, Gang Chang#, Wenqiang Liu, Xiaochen Kou, Kun Tan, Li Tao, Kai Xu, Hong Wang, Jun Cai*, Jianhui Tian*, Shaorong Gao* Unique features of mutations revealed by sequentially reprogrammed induced pluripotentstem cells. Nature Communications, 2015,6:6318.. 
10. Rongrong Le, Zhaohui Kou, Yonghua Jiang, Ming Li, Bo Huang, Wenqiang Liu, Hui Li, Xiaochen Kou, Wanzhong He, Karl Lenhard Rudolph, Zhenyu Ju* and Shaorong Gao*. Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells. Cell stem cell, 2014, 14 (1): 27-39 
11. Yawei Gao#, Jiayu Chen#, Ke Li, Tong Wu, Bo Huang, Wenqiang Liu, Xiaochen Kou, Yu Zhang, Hua Huang, Yonghua Jiang, Chao Yao, Xiaolei Liu, Zhiwei Lu, Zijian Xu, Lan Kang, Jun Chen, Hailin Wang, Tao Cai* and Shaorong Gao*. Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell, 2013, 12 (4): 453-469  

 

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