The cellular and molecular basis of tissue regeneration: insights from planarian model
Myresearch is focused on understanding the molecular and cellular basis of tissue regeneration using freshwater planarian S. mediterranea as a model organism. Planarian provides a particularly tractable system to approach this goal because it is one of the simplest metazoans possessing remarkable regenerative capability, and because it has become relatively easy to molecularly manipulate this organism. Using planarian as a model system, I will take a multidisciplinary approach combining molecular biology, genetics, optical imaging and single cell technologies to identify the cellular originsand epigenetic mechanism of regeneration processes.
Employment and Education
- 2013.10-present Postdoctoral associate, Stowers Institute for Medical Research/HHMI, USA. (Supervisor: Dr. Alejandro Sánchez Alvarado)
- 2006.9-2013.5 Ph.D. in Molecular Biology and Biochemistry, Shanghai Institute for BiologicalSciences, China. (Supervisor: Dr. Qing Jing)
- 2002.9-2006.7 B.S. in Biological Sciences, Liaoning University, China
- 1.Zeng A et al.,Prospectively isolated Tetraspanin+ neoblasts are adult pluripotent stem cells that underlie planaria regeneration. 2018 (CELL, in press).
- 2.Zeng A et al., Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells.Journal of Cell Biology.2013.
- 3.Li Y, Zeng A, et al., Dynamic regulation of small RNAome during the early stage of cardiac differentiation from pluripotent embryonic stem cells. Genomics Data. 2017.
- 4. Tian FJ, An LN, Wang GK, Zhu JQ, Li Q, Zhang YY, Zeng A, et al.,. Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis.Cardiovascular Research. 2014.
- 5.Li YQ, Zeng A, et al., Argonaute-2 regulates the proliferation of adult stem cells in planarian. Cell Research. 2011.