康 岚

姓        名康岚

学        位:博士

导师情况:博士生导师

研究领域干细胞生物学,发育生物学

研究方向

      1、体细胞重编程的分子机制。
      2、非编码RNA在胚胎发育中的功能及调控机制。
      3、多能干细胞向生殖细胞定向分化的机制及应用。

E-mail: kanglan@tongji.edu.cn
联系电话021-65987363
通讯地址:上海市四平路1239号同济大学生命科学与技术学院

实验室网址:http://life.tongji.edu.cn/gaolab/

个人简历:
       2007年毕业于武汉大学生命科学学院,获学士学位。2012年毕业于北京协和医学院,北京生命科学研究所,获博士学位。2012年10月-2018年1月于大连医科大学担任教授。2018年2月起任同济大学生命科学与技术学院教授。2009年首次证明了iPS细胞的完全多能性,在国内外引起广泛关注,被美国时代杂志评为2009年世界十大医学突破之一。获得多项国家和省级科研基金支持,包括国家自然科学基金委面上项目,优秀青年项目以及辽宁省优秀人才支持计划项目,此外,以骨干身份参与了教育部“创新团队发展计划”。迄今为止,在本领域知名期刊Cell Stem Cell,Cell Research,Stem Cell Report等期刊上发表多篇论文,累计引用600余次。

 代表性论文:

  1. Wu L, Wu Y, Peng B, Hou Z, Dong Y, Chen K, Guo M, Li H, Chen X, Kou X, Zhao Y, Bi Y, Wang Y, Wang H, Le R, Kang L#, Gao S (2017)  Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation.Stem Cell Reports 9(5):1692-1705 (Co-correspondence author)
  2. Li X, Ma C, Zhang L, Li N, Zhang X, He J, He R, Shao M, Wang J, Kang L#, Han C (2017)LncRNAAC132217.4, a KLF8-regulated long non-coding RNA, facilitates oral squamous cell carcinoma metastasis by upregulating IGF2 expression.Cancer Letter 407:45-56. (Co-correspondence author)
  3. Qin S, Yang D, Chen K, Li H, Zhang L, Li Y, Le R, Li X, Gao S and Kang L (2017)Pkm2 can enhance pluripotency in ESCs and promote somatic cell reprogramming to iPSCs.Oncotarget 8:84276-84284. (Co-correspondence author)
  4. Feng X, Xu X, Xiao X, Zou K, Yu W, Wu J, Tang R, Gao Y, Hao J, Zhao X, Liao Y, Chen Y, Huang W, Guo W, Kang L#, Deng W (2017)NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer.Cell Death & Disease 8(5):e2783. (Co-correspondence author)
  5. Wang M, Zhang Y, Wang T, Zhang J, Zhou Z, Sun Y, Wang S, Shi Y, Luan X, Zhang Y, Wang Y, Wang Y, Zou Z, Kang L#, Liu H (2015)The USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status.Cell Physiol Biochem 43(5):1755-1766. (Co-correspondence author)
  6. Hao J, Xu H, Luo M, Yu W, Chen M, Liao Y, Zhang C, Zhao X, Jiang W, Hou S, Feng X, Zou K, Chen Y, Huang W, Guo W, Kang L#, Deng W (2017)The tumor-promoting role of TRIP4 in melanoma progression and its involvement in response to BRAF-targeted therapy.J Invest Dermatol 138(1):159-170 (Co-correspondence author)
  7. Kang L#, Wu J, Tao Y, Li H,Liu X,Gao S, Wang Q (2015)Cell Type-Specific Expression Profile and Signaling Requirements in Early Hematopoietic Reprogramming.Stem Cells and Development 24(12):1483-92. (Co-correspondence author)
  8. Kang L, Gao S (2012)Pluripotency of induced pluripotent stem cells.J Anim Sci Biotechnol 2012 Feb 28;3(1):5
  9. Kang L, Wu T, Tao Y, Yuan Y, He J, Zhang Y, Luo T, Kou Z, Gao S (2011)Viable mice produced from three-factor induced pluripotent stem (iPS) cells through tetraploid complementation.Cell Research 21(3):546-9.
  10. Kang L, Kou Z, Zhang Y, Gao S (2010)Induced pluripotent stem cells (iPSCs)--a new era of reprogramming.Journal of Genetics and Genomics 7(7):415-21.
  11. Kou Z*, Kang L*, Yuan Y, Tao Y, Zhang Y, Wu T, He J, Wang J, Liu Z, Gao S (2010)Mice cloned from induced pluripotent stem cells (iPSCs).Biology of Reproduction 83(2):238-43. (Co-first author)
  12. Kang L, Wang J, Zhang Y, Kou Z, Gao S (2009)iPS cells can support full term development of tetraploid blastocyst-complemented embryos.Cell Stem Cell 5(2):135-138.

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