龚国华

姓        名:龚国华

学        位:博士

导师情况:博士生导师

研究领域:线粒体与细胞命运

研究方向

      1.线粒体的质量控制同疾病的发生发展;
       2. 线粒体同多能干细胞命运决定;
       3. 调控干细胞线粒体发育和衰老细胞线粒体功能的靶点研究;
       4. 线粒体移植同细胞命运和功能。

     E-mailguohgong@tongji.edu.cn

     联系电话:021-65982260

     通讯地址:上海市杨浦区四平路1239号,同济大学生命科学与技术学院,邮编200092

 

个人简介:

        2010年博士毕业于四川大学,获理学博士学位,博士期间主要进行天然产物治疗心血管疾病的药理学和代谢研究。 2010年至2013年在美国华盛顿大学(University of Washington )医学院对可在体监测单个线粒体功能的 “超氧炫(mitoflash)” 的发生机制和生理学意义进行研究。2013年至2015年在圣路易斯华盛顿大学(Washington University in St.Louis )医学院从事心肌线粒体发育和线粒体质量控制的博士后研究。2016年入选同济大学基础学科高水平“领航人才计划”,获得上海“浦江人才“, “东方学者特聘教授"。已在包括《Science》 和 《Nature》 等期刊发表发表SCI学术论文20余篇,他引500多次 。

 

课题主持:
1. 国家自然科学基金面上项目,31771524,2018/01-2021/12,72万,主持
2. 科技部干细胞与转化研究重点专项,2017YFA0105600,2017/07-2021/12, 465.0 万,子课题组长
3. 上海市科委,17PJ1409600,2017/07-2019/06,20万,主持
4. 上海市东方医院,DFRC2017001,2017/12-2021/05,主持

 

代表论文:

  1. Franco A, Kitsis R,Fleischer J, Gavathiotis E, Kornfeld O, Gong G, Biris N, Benz, Nir Qvit A, Donnelly S, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn G. (2016). Correcting Mitochondrial Fusion by Manipulating Mitofusin Conformations. Nature(Article) doi: 10.1038/nature20156. [Epub ahead of print].
  2.  Xu S, Wang P, Zhang H, Gong G, Gutierrez Cortes N, Zhu W, Yoon Y, Tian R, Wang W. (2016). CaMKII Induces Permeability Transition Through Drp1 Phosphorylation During Chronic β-AR Stimulation. Nature Communication 14(7)13189. doi: 10.1038/ncomms13189.
  3. Wang W, Gong G, Wang X, Wei-LaPierre L, Chemg H, Dirksen R, Sheu S. (2016). Mitochondrial Flash: Integrative ROS and pH Signals in Cell and Organelle Biology. Antioxidants & Redox Signaling. 25 (9): 534-49.
  4. Gong G, Song M, Csordas G, Kelly D, Matkovich S, Dorn G. (2015). Parkin-Mediated Mitophagy Directs Perinatal Cardiac Mitochondrial Metabolic Maturation In Mice. Science (Article). 350: aad2459. DOI: 10.1126/science. aad2459. (Highlighted by The Perspective of Science. 2015, 350: 1162-1163; the EDITORS’ CHLICE of Sci. Signal. 2015, 406: EC367)
  5. Gong G, Liu X, Zhang H, Sheu S, Wang W. (2015). Mitochondrial Flash as A Novel Biomarker of Mitochondrial Respiration in The Heart. American Journal of Physiology Heart and Circulatory Physiology. 309 (7): H1166-H1177. (Featured article, Featured Podcast)    
  6. Song M, Gong G, Burelle Y, Gustafsson A, Kitsis R, Matkovich S, Dorn G. (2015). Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circulation Research. 117 (4): 346-351. (Featured article)
  7. Song M, Chen Y, Gong G, Murphy E, Rabinovitch  P, Dorn G. (2014). Super-Suppression of Mitochondrial Reactive Oxygen Species Signaling Impairs Compensatory Autophagy in Primary Mitophagic Cardiomyopathy. Circulation Research. 115 (3):348-53. (Featured article, 2014 Circ Res Best Manuscript Award)
  8. Gong G*, Liu X*, Wang W. (2014). Regulation of Metabolism in Individual Mitochondria during Excitation-Contraction Coupling. Journal of Molecular Cellular Cardiology. 76: 235-246. (Equal contribution)  
  9. Kim M, Hunter R, Garcia-Menendez L, Gong G, Yang Y, Kolwicz S, Xu J, Sakamoto K, Wang W, Tian R. (2014).  Mutation in The γ2-subunit of AMP-Activated Protein Kinase Stimulates Cardiomyocyte Proliferation and Hypertrophy Independent of Glycogen Storage. Circulation Research. 114 (6): 966-975. (Featured article)
  10. Karamanlidis G, Garcia-Menendez L, Kolwicz S, Suthammarak W, Gong G, Sedensky M, Morgan P, Wang W, Tian R. (2013). Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure. Cell Metabolism. 18 (2): 239-250.
  11. Gong G, Wang W. (2013). Confocal Imaging of Single Mitochondrial Superoxide Flashes in Intact Heart or in vivo. Journal of Visualized  Experiments (JoVE). 81: e50818, doi:10.3791/50818.
  12. Wei-LaPierre L*, Gong G*, Gerstner B, Ducreux S, Yule D, Pouvreau S, Wang X, Sheu S, Cheng H, Dirksen R, Wang W. (2013). "Respective Contribution of Mitochondrial Superoxide and pH to Mt-cpYFP Flash Activity."  Journal Biological Chemistry. 288 (15): 10567~ 10577. (Equal contribution)
  13. Huang Z, Zhang W, Gong G, Fang H, Zheng M, Wang X, Xu J, Dirksen R, Sheu S, Cheng H, Wang W. (2011). Response to “A Critical Evaluation of EpYFP as A Probe for Superoxide. Free Radical Biology and Medicine. 51 (10): 1937~1940.
  14. Gong G, Qin Y, Huang W. (2011). Anti-Thrombosis Effect of Diosgenin from Dioscorea Zingiberensis C.H.Wright in Rodents. Phytomedicine. 2011, 18 (6): 458~463.
  15. Gong G, Qin Y, Huang W, Zhou S, Wu X, Yang X, Li D. (2010). Protective Effects of Diosgenin in The Hyperlipidemic Rat Model and Human Vascular Endothelial Cells Against Hydrogen Peroxide-induced Apoptosis. Chemico-Biological Interactions. 184 (3): 366~375.
  16. Gong G, Qin Y, Huang W, Zhou S, Yang X, Li D. (2010). Rutin Inhibits Hydrogen Peroxide-Induced Apoptosis through Regulating ROS-Mediated Mitochondrial Dysfunction Pathway in Human Umbilical Vein Endothelial Cells. European Journal of Pharmacology. 628 (1-3): 27~35.

实验室欢迎有志于生物医学研究的研究生和本科生报考和实习,同时欢迎具有生物医学(动物医学)相关研究经历的副研究员, 博士后加盟,本实验室长期招聘博士后。

 

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