(6月12日) Control the behavior of stem cells for regenerative medicine applications
报 告 人：尹晓磊 博士
主 持 人：高绍荣 教授
时 间：6月12日 上午10：00
Stem cells hold great potential to regenerate damaged tissue through exerting their self-renewal and differentiation abilities. Adult stem cells, which exist in many tissues and organs in the body, could be used to restore healthy tissue when properly regulated. My research focuses on deciphering the mechanisms of the self-renewal and differentiation of adult stem cells, and developing strategies to treat diseases through controlling the behavior of adult stem cells. Using an Lgr5 intestinal stem cell organoid model, I identified small molecule combinations to regulate their behavior, which were further translated into the inner ear stem cell system to treat hearing loss.
Employment and Education
2014-present Instructor in medicine, Harvard Medical School, USA
2010-2014 Postdoctoral associate, Massachusetts Institute of Technology, USA
2004-2009 Ph.D. in Cell Biology, Peking University, China
2000-2004 B.S. in Biological Sciences, Pekin University, China
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2. Yin X., Mead BE, Safaee H, Langer R, Karp JM, Levy O. Engineering Stem Cell Organoids. Cell Stem Cell. 2016 Jan 7. Invited Review. Cover Feature.
3. Yin X., Farin H.F., van Es JH., Clevers H., Langer R., Karp J.M. Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. Nature Methods. 2014 Jan:11.
4. Zhao Y.#, Yin X.#, Qin H.#, Zhu F., Liu H., et al., Ding M., and Deng H., Two supporting factors greatly improve the efficiency of human iPS cell generation. Cell Stem Cell. 2008 Nov 6.